View source for Cefipime

==General==
*Type: cephalosporin (4th generation)
*Dosage Forms: IM/IV
*Common Trade Names: Maxipime

==Adult Dosing==
*1-2 g IV q12h

====febrile neutropenia====
*2g IV q8h

====UTI, mild-mod====
*0.5g - 1g q12h x 7-10days

====UTI, severe====
*2g IV q12h x 10days

==Pediatric Dosing==

====infection, bacterial====
>2 months<br />

50mg/kg IV/IM q12hr, max 2g/dose

====febrile neutropenia====
>2 months<br />

50mg/kg IV/IM q8h; max 2g/dose

====resp. infection, cystic fibrosis patients====
> 2 months<br />

50mg/kg IV/IM q8h; max 2g/dose

==Special Populations==
*Pregnancy: Category B (no evidence of risk in humans)
*Lactation: very small amount excreted, adverse effects unlikely, infant should be monitored closely
*Renal Dosing
**Adult
***febrile neutropenia
****GFR 30-60: 2g q12h
****GFR 11-29: 2g q24h
****GFR < 11: 2g x1, then 1g q24h
****HD: 1g q24, give after dialysis
****PD: 2g q24h
***all other infections 
****GFR 30-60: q24h dosing
****GFR 11-29: give usual dose x1, then 0.5-1g q24
****GFR < 11: give usual dose x1, then 250-500mg q24h
****HD: 1g x1, then 500mg q24h, give after dialysis
****PD: usual dose q48h
**Pediatric
***febrile neutropenia, cystic fibrosis
****GFR 30-60: 50mg/kg q12h
****GFR 11-29: 50mg/kg q24h
****GFR < 11: 50mg/kg x1, then 25mg/kg q24
****HD: 25mg/kg q24, give after dialysis
****PD: 50mg/kg q48
***all other infections
****GFR 30-60: 50mg/kg q24
****GFR 11-29: 50mg/kg x1, then 25-50mg/kg q24
****GFR < 11: 50mg/kg x1, then 12.5-25mg/kg q24h
****HD: 50mg/kg x1, then 25mg/kg q24h, give after dialysis
****PD: 50mg/kg q48h
*Hepatic Dosing
**Adult: no adjustment
**Pediatric: no adjustment

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===
*anaphylaxis
*encephalopathy
*seizures
*non-convulsive status epilepticus
*leukopenia
*thrombocytopenia
*agranulocytosis
*anemia, hemolytic
*aplastic anemia
*hemorrhage
*Stevens Johnson Syndrome
*toxic epidermal necrolysis
*erythema multiforme
*C.difficile associated diarrhea

===Common===
*rash
*infection site reaction
*diarrhea
*hypophosphatemia
*ALT, AST elevation
*nausea

==Pharmacology==
*Half-life: 
**2h, 13.5h (HD), 19h(CAPD)
*Metabolism: 
**minimal, site unknown
*Excretion: 
**urine primarily (85% unchanged)
*Mechanism of Action: 
**bacteriacidal, inhibits cell wall mucopeptide synthesis

==See Also==
*[[Antibiotics (Main)]]

==References==

<references/>
[[Category:Pharmacology]]