View source for Lindane

==Administration==
*Type: Pediculicide
*Dosage Forms:
*Routes of Administration: topical
*Common Trade Names: 

==Adult Dosing==
''Second line therapy only for patients who have failed other agents''
*Scabies: apply thin layer and massage on entire body except face, remove after 8-12h
*Head lice: apply 1-2 oz of shampoo on dry hair, leave on for 4min, lather/rinse and remove nits with fine comb

==Pediatric Dosing==
''Second line therapy only for patients who have failed other agents''
''Caution if patient weighs <50kg''
*Scabies: apply thin layer and massage on entire body except face, remove after 8-12h
*Head lice: apply 1-2 oz of shampoo on dry hair, leave on for 4min, lather/rinse and remove nits with fine comb

==Special Populations==
===[[Drug pregnancy categories|Pregnancy Rating]]===
*Pregnancy Category C

===Lactation risk===
*Do not breastfeed for 24h after application

===Renal Dosing===
*Adult:
*Pediatric:

===Hepatic Dosing===
*Adult: Use caution
*Pediatric: Use caution

==Contraindications==
*Allergy to class/drug
*Premature neonates (<28 do) (increased absorption)
*Uncontrolled seizure disorder
*Norwegian (crusted) scabies
*Skin conditions that may increase systemic absorption (weeping surface, inflamed skin etc)
*Caution with:
**HIV infection
**Prior seizure
**Prior head trauma
**CNS tumor
**Severe hepatic cirrhosis 
**Excess alcohol use or abrupt withdrawal from alcohol or benzos
**Concomitant use of meds that lower seizure threshold
**Weight <50kg

==Adverse Reactions==
===Serious===
*Neurotoxicity (seizures), ataxia
*Arrhythmia
*Pulmonary edema
*Aplastic anemia

===Common===
*Skin irritation, contact dermatitis, alopecia, urticaria
*Dizziness
*Restlessness
*Hematuria
*Paresthesia
*Nausea/vomiting

==Pharmacology==
*Half-life: 17-22h
*Metabolism: liver
*Excretion: urine and feces

==Mechanism of Action==
*"Following absorption through the chitinous exoskeleton of arthropods, cyclic chlorinated hydrocarbons like lindane presumably stimulate the nervous system, resulting in seizures & death of parasite"<ref>https://reference.medscape.com/drug/lindane-topical-343501#10</ref>

==Comments==
*Black box for neurotoxicity, banned in several countries and California due to neurotoxicity

==See Also==
*[[Permethrin]]

==References==
<references/>

[[Category:Pharmacology]]