View source for Ziprasidone

==Administration==
*Type: Atypical [[antipsychotic]]
*Dosage Forms:
*Routes of Administration: PO, IM
*Common Trade Names: Geodon

==Adult Dosing==
*Mania/psychosis: 40 to 80 mg PO BID
*Acute agitation: 10-20mg IM q2-4h, 40mg max daily
==Pediatric Dosing==
*Age 10-17: slowly titrate up to  target dose 20-80mg BID
==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
*[[Lactation risk categories|Lactation risk]]: Infant risk cannot be ruled out
*Renal dosing: no adjustment
*Hepatic dosing: no adjustment

==Contraindications==
*Allergy to class/drug
*[[QT prolongation]], concomitant administration of other QT prolonging medications
*Decompensated [[heart failure]], recent [[MI]]

==Adverse Reactions==
===Serious===
*Prolonged QT, torsades de pointes, syncope
*Neuroleptic malignant syndrome, tardive dyskinesia, seizure
*Bone marrow depression
*Dysphagia
*Hyperglycemia, diabetes
*Priapism
===Common===
*Extrapyramidal disease, dystonia, tremor, akathisia
*Dizziness, asthenia, somnolence, anxiety
*Nausea/vomiting, diarrhea, constipation
*Weight gain
*Rash
*Visual changes
*URI
==Pharmacology==
*Half-life: 2-7h
*Metabolism: Hepatic: CYP3A4, and CYP1A2
*Excretion: Mostly fecal

==Mechanism of Action==
*D2 and 5HT2 antagonist. Also strong α-1 blocker, antihistamine-1.
==Comments==

==See Also==
*[[Antipsychotics]]
==References==
<references/>
[[Category:Pharmacology]]
[[Category:Psychiatry]]