View source for Acute transfusion reaction

==Background==
*If concern for fluid overload, may need to transfuse as split pRBCs to tranfuse as slow as 1mL/kg/hr
*Sepsis is most commonly due to [[yersinia]], which is able to grow easily in refrigerated blood

{{Transfusion risk}}

==Clinical Features==
*Etiology specific, see ddx below

==Differential Diagnosis==
{{Transfusion reaction types}}

{{Acute Allergic DDX}}

==Evaluation==
*Workup of hemolytic reaction
**CBC with microscopy differential
**Formal urinalysis with bilirubin
**Haptoglobin, LDH, free hemoglobin
**Serum total and direct bilirubin
**Coombs test of pre-transfusion and post-transfusion blood
[[File:Coombs.png|thumbnail]]
*Consider CXR to help differentiate anaphylaxis, TRALI, TACO
{{TRALI vs TACO}}

==Management==
*For all reactions:
**Stop the transfusion (at least temporarily)
**Call the blood bank
**Draw a new type + screen

==Disposition==

==See Also==
{{Transfusion reactions see also}}

==References==
<references/> 

[[Category:Heme/Onc]]