View source for Atenolol

==General==
*Type: [[Beta blocker]]
*Dosage Forms: tablet
*Dosage Strengths: 25, 50, 100mg
*Routes of Administration: PO
*Common Trade Names: Tenormin

==Adult Dosing==
===[[Hypertension]]===
*50-100mg PO QD, Start 50mg PO QD
*Max: 100mg/day

===[[Stable angina]]===
*50-200mg PO QD, Start 50mg PO QD
*Max: 200mg/day

===Cardiovascular event prevention, post-MI===
*100mg/day PO divided QD-bid

==Pediatric Dosing==
===[[Hypertension]]===
*1-2mg/kg PO QD, Start 0.8-1mg/kg PO QD
*Max: 2mg/kg/day

===[[Supraventricular arrhythmias]]===
*0.3-2mg/kg PO QD
*Max: 2mg/kg/day

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: D 
*Lactation: Possibly unsafe
*Renal Dosing
**Adult: CrCl 10-50: decrease dose 50%, give q48h, max 50mg/day; CrCl<10: decrease dose 50-70%, give q96h, max 25mg/day; HD: give dose after dialysis, no supplement; PD: no supplement
**Pediatric: CrCl 30-50: max 1mg/kg up to 50mg q24h; CrCl<30: max 1mg/kg up to 25mg q24h or up to 50mg q48h; HD: give dose after dialysis, no supplement; PD: no supplement
*Hepatic Dosing
**Adult: not defined
**Pediatric: not defined

==Contraindications==
*Allergy to class/drug
*sinus bradycardia
*2nd or 3rd degree AV block
*heart failure, uncompensated
*cardiogenic shock
*sick sinus syndrome with out pacemaker
*pheochromocytoma, untreated
*avoid abrupt withdrawal
*caution if peripheral vascular disease
*caution if bronchospastic disease
*caution if major surgery
*caution if diabetes mellitus
*caution if thyroid disorder
*caution if WPW syndrome
*caution if renal impairment
*caution if pregnancy
*caution if breastfeeding
*caution if myasthenia gravis
*caution if severe anaphylactic reaction history
*caution in elderly patients

==Adverse Reactions==
===Serious===
*[[CHF]]
*[[bradycardia]], severe
*heart block
*angina exacerbation if abrupt discontinuation
*[[Myocardial infarction]] if abrupt discontinuation
*ventricular arrhythmia during treatment and if abruptly discontinue
*Raynaud phenomenon
*bronchospasm
*hypersensitivity reaction
*lupus erythematosus

===Common===
*bradycardia
*hypotension
*fatigue
*dizziness
*cold extremities
*depression
*dyspnea
*hypotension, orthostatic
*leg pain
*bronchospasm
*lightheadedness
*lethargy
*diarrhea
*nausea
*vertigo
*drowsiness

==Pharmacology==
*Half-life: 6-7h
*Metabolism: CYP450
*Excretion: urine 40-50%, feces 50%
*Mechanism of Action: selectively antagonizes beta-1 adrenergic receptors

==See Also==
*[[Beta-blockers]]
*[[Beta-blocker toxicity]]
*[[Antiarrhythmics]]
*[[Antihypertensive medications]]

==References==
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[[Category:Pharmacology]] [[Category:Cardiology]]