View source for Dimenhydrinate

==Administration==
*Type: [[Antiemetics]]; [[Antihistamines]]
*Dosage Forms:
*Routes of Administration: oral, IV/IM
*Common Trade Names: Dramamine

==Adult Dosing==
===Motion Sickness===
*50mg PO/IV/IM q4-6h
**Maximum Dose: 400 mg within 24 hours

==Pediatric Dosing==
===Motion Sickness===
*2-6yo: 12.5-25mg PO q6-8 hrs
**Maximum Dose: 75 mg within 24 hours
*6-12yo:  25-50mg PO q6-8h
**150 mg within 24 hours
*1.25 mg/kg IM q6h

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: B
*[[Lactation risk categories|Lactation risk]]: Milk effects are posible
*Renal dosing:
*Hepatic dosing: consider dose reduction

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===
*[[Anticholinergic toxicity]]

===Common===
*Nausea, vomiting
*Sedation

==Pharmacology==
*Half-life: 5-8 hours
*Metabolism: Liver
*Excretion: Renal

==Mechanism of Action==
*Precise anti-nausea mechanism unknown, has depressant action on hyperstimulated labyrinthine function

==Comments==
*Dimenhydrinate is a combination drug of [[diphenhydramine]] and 8-chlorotheophylline
*Used recreationally as a deliriant<ref>Abuse and Misuse Potential of Dimenhydrinate: A Review of the Clinical Evidence. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; December 1, 2015.</ref>

==See Also==
*[[Antiemetics]]
*[[Anticholinergic toxicity]]

==References==
<references/>
[[Category:Pharmacology]]