View source for Fludrocortisone

==Administration==
*Type: [[Corticosteroid]]
*Dosage Forms: 0.1 mg oral tablets
*Routes of Administration: PO
*Common Trade Names: Florinef (note: brand discontinued in US)

==Adult Dosing==
*Adrenal Insufficiency
**0.1 mg 3 times per week to 0.2 mg daily. Give with food or milk. Taper dose gradually to d/c.
*Orthostatic Hypotension
**0.1 mg PO qD initially then may increase by 0.1 mg/d weekly up to a max of 1 mg/d (>0.5 mg rarely helpful). Taper dose gradually to d/c.

==Pediatric Dosing==
''NOT FDA approved in children''
*0.05-0.2 mg/day

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
*[[Lactation risk categories|Lactation risk]]: Infant risk cannot be ruled out
*Renal dosing: no adjustment
*Hepatic dosing: no adjustment

==Contraindications==
*Allergy to class/drug
*Systemic fungal infections

==Adverse Reactions==
===Serious===
*Secondary adrenal insufficiency
*Elevated ICP, seizure
*CHF, cardiomegaly, hypertension
*Thrombophlebitis
===Common===
*Bruising, petechiae
*Impaired wound healing
*Hyperglycemia, hypokalemia
*Rash, urticaria
*Peptic ulcer disease
*Irregular menses, growth delay (children)
*Headache, vertigo

==Pharmacology==
*Half-life: 3.5 hours
*Metabolism: Hepatic, kidney
*Excretion: urine

==Mechanism of Action==
*Very potent mineralocorticoid, also has glucocorticoid effects

==Comments==

==See Also==
*[[Corticosteroids]]
*[[Adrenal insufficiency]]

==References==
<references/>
[[Category:Pharmacology]]