View source for Flurazepam

==Administration==
*Type: [[Benzodiazepine]]
*Dosage Forms: CAP 15mg, 30mg
*Routes of Administration: Oral
*Common Trade Names: Dalmane

==Adult Dosing==
===[[Insomnia]], short term tx===
*15mg PO qhs

==Pediatric Dosing==
Safety/efficacy not established in pediatric patients

==Special Populations==
===[[Drug pregnancy categories|Pregnancy Rating]]===
*Category C
*Consider alternatives in pregnancy
*Risk of neonatal withdrawal and floppy infant syndrome

===Lactation risk===
*Use alternative or consider short-acting benzodiazepines while breastfeeding

===Renal Dosing===
*Adult: No adjustment
*Pediatric: Not defined

===Hepatic Dosing===
*Adult: Not defined.
*Pediatric: Not defined

==Contraindications==
*Allergy to class/drug
*Pregnancy
*Avoid abrupt withdrawal with long-term use

==Adverse Reactions==
===Serious===
*[[Anaphylaxis]]
*[[Angioedema]]
*Complex sleep-related behavior
*Respiratory depression, [[tachycardia]], hypotension, [[syncope]]
*Dependency, suicidality
*[[Seizures]]

===Common===
*[[Dizziness]], drowsiness, ataxia, confusion, [[headache]]
*Disinhibition, irritability
*[[Dystonia]], [[dysarthria]]
*Appetite change, menstrual irregulatrity
*Incontinence
*[[Rash]]

==Pharmacology==
*Half-life: 2-3h; 40-100h active metabolite
*Metabolism: Liver extensively; 3A4 partial substrate
*Excretion: Urine

==Mechanism of Action==
*Binds to [[benzodiazepine]] receptors to enhance GABA effects

==Comments==


==See Also==
*[[Benzodiazepine]]

==References==
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[[Category:Pharmacology]]