View source for Meclizine

==General==
*Type: [[Antihistamine]], H1 antagonist
*Dosage Forms: 12.5, 25, 32mg oral tablet; 25mg oral chewable tablet
*Common Trade Names: Univert, Vertin-32, Dramamine less drowsy, Motion-Time

==Adult Dosing==
===[[Vertigo]]===
*25mg PO QID

===[[Motion sickness]]===
*25-100mg PO 1 hour before activity. May repeat q24h

==Pediatric Dosing==
*>= 12 yrs old: Adult dosing
*< 12 yrs: No dosing specified in drug insert

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: B
*Lactation: Excretion in breast milk unknown
*Renal Dosing: n/a
*Hepatic Dosing: n/a

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===
*CNS depression
*Caution in asthma, glaucoma, BPH, pyloric obstruction
===Common===
*Drowsiness, fatigue

==Pharmacology==
*Onset: 1 hour
*Half-life: 5 hours
*Metabolism: Hepatic
*Excretion: Urine and feces
*Mechanism of Action: Central anticholinergic; blocks chemoreceptor trigger zone. Decreases middle ear excitability, blocks vestibular-cerebellar pathways


==Indications by Condition==
''The following table is automatically generated from disease/condition pages across WikEM.''

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 |?Has Route=Route
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==See Also==
*[[Antihistamines]]
*[[Anticholinergic toxicity]]

==References==
Lexicomp
<references/>
[[Category:Pharmacology]]