View source for Mirtazapine

==Administration==
*Type: Atypical antidepressant
*Dosage Forms:
*Routes of Administration: oral 
*Common Trade Names: Remeron

==Adult Dosing==
*15-45mg PO nightly

==Pediatric Dosing==
''Safety/efficacy not established''

==Special Populations==
*[[Drug pregnancy categories|Pregnancy Rating]]: C
*Lactation risk: Infant risk cannot be ruled out
*Renal dosing, CrCl <40: increase dose slowly
*Hepatic impairment: increase dose slowly

==Contraindications==
*Allergy to class/drug
*MAOI use concomitantly or within past 14 days

==Adverse Reactions==
===Serious===
*Agranulocytosis, neutropenia
*Neuroleptic malignant syndrome, serotonin syndrome
*Seizure, status epilepticus
*Exacerbation of depression, suicidality
*Cirrhosis
===Common===
*Increased appetite, weight gain, elevated triglycerides, constipation, xerostomia
*Dizziness, somnolence, disturbance in thinking

==Pharmacology==
*Half-life: 26-37h
*Metabolism: Hepatic, CYP2D6, CYP1A2, and CYP3A4
*Excretion: Mostly renal

==Mechanism of Action==
*Exact mechanism of action unknown. Potent serotonin 5HT2 and 5HT3 antagonist, moderate muscarinic antagonist. Side effects due to antihistaminergic and α-1 antagonist properties

==Comments==


==See Also==
*[[Depression]]

==References==
<references/>

[[Category:Pharmacology]]
[[Category:Psychiatry]]