View source for Pralidoxime

==General==
*Also known as 2-PAM
*Type: [[Antidote]]
*Dosage Forms:
*Common Trade Names: Protopam

==Adult Dosing==
===[[Organophosphate toxicity]]===
*1-2gm IV over 5-10min
*Continuous infusion of 500mg/hr if no initial response

==Pediatric Dosing==
===[[Organophosphate toxicity]]===
*20-40mg/kg (up to 1gm) IV over 5-10min
*5-10mg/kg/hr if no initial response

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
*[[Lactation risk categories|Lactation risk]]: Unknown
*Renal Dosing
**Adult - no requirements from manufacturer, but given that it is excreted in the urine dosage reduction is recommended. 
**Pediatric
*Hepatic Dosing
**Adult - no adjustments recommended by manufacturer. 
**Pediatric

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===
*[[Laryngospasm]]
*Myasthenic crisis in patients with Myasthenia gravis
*Hepatitis

===Common===
*Blurry vision
*Diplopia
*Nausea
*Tachycardia
*Hypertension

==Pharmacology==
*Half-life: Apparent: 74 to 77 minutes, IM/IV exposure: 3 to 4 hours
*Metabolism: Hepatic
*Excretion: Urine
*Mechanism of Action: Displaces an organophosphate from acetylcholinesterase (if given early before irreversible enzyme binding occurs, aka "aging")

==Comments==


==Indications by Condition==
''The following table is automatically generated from disease/condition pages across WikEM.''

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==See Also==
[[Organophosphate Toxicity]]
==References==
<references/>
[[Category:Pharmacology]]
[[Category:Toxicology]]