View source for SGLT-2 Inhibitor

==Administration==
*Type: Oral [[Diabetes medication]]
*Canagliflozin (Invokana), Dapagliflozin (Farxiga), Empagliflozin (Jardiance) are FDA approved for use in type 2 diabetes

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===
*Euglycemic [[DKA]]<ref>[https://www.fda.gov/Drugs/DrugSafety/ucm446845.htm FDA Drug Safety Communication: FDA warns that SGLT2 inhibitors for diabetes may result in a serious condition of too much acid in the blood]</ref>
*Fournier's gangrene (rare)

===Common===
*[[UTI]]
*Genital [[candidiasis]]
*Weight loss
*Dehydration/Orthostasis

==Mechanism of Action==
*Inhibit sodium-glucose cotransporter 2, decreasing glucose reabsorption in the proximal tubule

==See Also==
*[[Diabetes medications]]
*[[Diabetic ketoacidosis]]
*[[Hyperglycemia]]

==References==
<references/>

[[Category:Pharmacology]]
[[Category:Endocrinology]]