View source for Template:Jaundice DDX

===[[Jaundice]]===
[[File:Classification of Hyperbilirubinemia.jpeg|thumb|Differential diagnosis of hyperbilirubinemia.]]
====Indirect Hyperbilirubinemia====
*Hemolytic
**[[G6PD]]
**Drug related
**[[Autoimmune hemolytic anemia]]
*Hematoma resorption
*Ineffective erythropoiesis
*Gilbert's

====Direct (Conjugated) Hyperbilirubinemia====
*[[Choledocholithiasis]]
*[[Cholecystitis]]
*Ascending [[cholangitis]]
*[[AIDS]] cholangiopathy
*Stricture
*Neoplasm
**Pancreatic head
**Gallbladder
**Primary liver (e.g. [[hepatocellular carcinoma]])
**Metastatic
*Obstructing [[AAA]]

====Hepatocellular damage====
''Patient will have severely elevated AST/ALT with often normal Alkaline Phosphatase''
*[[Viral hepatitis]]
*[[Acute liver failure|Fulminant hepatic failure]]
*[[alcoholic hepatitis]]
*[[Ischemic hepatitis]]
*Toxins
**[[Isoniazid]]
**[[Phenytoin]]
**[[Acetaminophen (Tylenol) Toxicity|acetaminophen]]
**Ritonavir
**Halothane
**Sulfonamide
*[[Autoimmune hepatitis]]
**Primary biliary cirrhosis
*[[HELLP Syndrome]]
*Congestive Hepatopathy
**[[CHF]]
**[[Sepsis]] ([[ischemic hepatitis|Shock Liver]])

====Pregnancy Related====
*[[HELLP syndrome]]
*[[Acute fatty liver of pregnancy]]
*[[Hyperemesis gravidarum]]
*[[Cholestasis of pregnancy]]

====Transplant Related====
*[[Transplant complications|Transplant rejection]]
*[[Graft-vs-host disease]]

====Pediatric Related====
*[[Inborn error of metabolism]]
*[[Neonatal jaundice]] (physiologic)

====Additional Differential Diagnosis====
*[[Reye syndrome]]
*TPN
*[[Heatstroke]]
*[[Budd-Chiari]] (with acute ascites)
*[[Wilson's disease]]
*[[Sarcoidosis]]
*[[Amyloidosis]]

====Masqueraders====
''Only bilirubin stains the sclera''
*[[Carotenemia]]
*Quinacrine ingestion
*Dinitrophenol, teryl (explosive chemicals)