View source for Template:Toxoplasmosis Antibiotics

====Immunocompetent====
''Antibiotics only needed if patient has severe symptoms''
*[[Pyrimethamine]] 200mg PO one dose (for loading) THEN 50mg PO q24hrs x4wks AND
**[[Leucovorin]] 10mg PO q24hrs AND
**[[Sulfadiazine]] 1g PO q6hrs

====Immunosprepressed====
*[[Pyrimethamine]] 200mg PO one dose (for loading) THEN 75mg PO q24hrs x4-8wks AND [[Leucovorin]] 25mg PO q24hrs PLUS
**[[Sulfadiazine]] 1500mg PO q6hrs OR
**[[Clindamycin]] 600mg PO or IV q6hrs OR
**[[Azithromycin]] 12000mg PO q24hrs OR
**[[Atovaquone]] 1500mg PO q12hrs
OR
*[[TMP/SMX]] 5mg/kg IV q12hrs

====Pregnant====
*[[Spiramycin]] 1 g orally every 8 hours<ref>Paquet C, Yudin MH. Toxoplasmosis in pregnancy: prevention, screening, and treatment. J Obstet Gynaecol Can. Jan 2013;35(1):78-9.</ref>
**If amniotic fluid is positive treat with 3 weeks of pyrimethamine (50 mg/day orally) + sulfadiazine (3 g/day orally in 2-3 divided doses)
**Alternate with a 3-week course of Spiramycin 1 g 3 times daily OR
*[[Pyrimethamine]] (25 mg/day orally) and sulfadiazine (4 g/day orally) divided 2 or 4 times daily until delivery AND
**[[Leucovorin]] 10-25 mg/day orally to prevent bone marrow suppression