Age adjusted D-dimer - Revision history

Danbot: Add Category:Labs

2026-03-22T06:43:57Z

← Older revision		Revision as of 06:43, 22 March 2026
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	[[Category:Pulmonary]]		[[Category:Pulmonary]]
	[[Category:Vascular]]		[[Category:Vascular]]
			[[Category:Labs]]

Rossdonaldson1 at 20:29, 15 July 2018

2018-07-15T20:29:26Z

← Older revision		Revision as of 20:29, 15 July 2018
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	*Risk stratification for all patients should take place using the [[Wells Criteria]]		*Risk stratification for all patients should take place using the [[Wells Criteria]]
	*Know your lab's assay cutoff and whether it is report as DDU or FEUs since the formula is different for the different assays		*Know your lab's assay cutoff and whether it is report as DDU or FEUs since the formula is different for the different assays

			==See Also==
			*[[D-dimer]]

	==References==		==References==

Mholtz at 11:58, 2 August 2017

2017-08-02T11:58:49Z

← Older revision		Revision as of 11:58, 2 August 2017
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	==Background==		==Background==
	*The [[PE]] derivation and validation study for usage of the [[EBQ:The ADJUST-PE Study\|age adjusted d-dimer]] formula concluded that when combining the d-dimer adjustment with clinical probability, less patients required CTA for exclusion and offered no clinical increase in the rate of missed [[Pulmonary embolism]]<ref>Douma R. et al. Potential of an age adjusted D-dimer cut-off value to improve the exclusion of pulmonary embolism in older patients: a retrospective analysis of three large cohorts. BMJ (Clinical research ed.) (March 30). 2010. doi:10.1136/bmj.c1475.</ref><ref>Douma, R. et al. Using an age-dependent D-dimer cut-off value increases the number of older patients in whom deep vein thrombosis can be safely excluded. Haematologica, no. 10 (April 17). 2012. doi:10.3324/haematol.2011.060657.</ref>		*The [[PE]] derivation and validation study for usage of the [[EBQ:The ADJUST-PE Study\|age adjusted d-dimer]] formula concluded that when combining the d-dimer adjustment with clinical probability, less patients required CTA for exclusion and offered no clinical increase in the rate of missed [[Pulmonary embolism]]<ref>Douma R. et al. Potential of an age adjusted D-dimer cut-off value to improve the exclusion of pulmonary embolism in older patients: a retrospective analysis of three large cohorts. BMJ (Clinical research ed.) (March 30). 2010. doi:10.1136/bmj.c1475.</ref><ref>Douma, R. et al. Using an age-dependent D-dimer cut-off value increases the number of older patients in whom deep vein thrombosis can be safely excluded. Haematologica, no. 10 (April 17). 2012. doi:10.3324/haematol.2011.060657.</ref>
	*Similarly, using the age adjusted d-dimer in combination with clinical probability can reduce the need for further testing in DVT evaluations with no substantial risk to patient safety<ref>Schouten, H et al.. Diagnostic accuracy of conventional or age adjusted D-dimer cut-off values in older patients with suspected venous thromboembolism: systematic review and meta-analysis. BMJ (Clinical research ed.) (May 3). 2013. doi:10.1136/bmj.f2492.</ref><ref>Schouten, H et al. Validation of two age dependent D-dimer cut-off values for exclusion of deep vein thrombosis in suspected elderly patients in primary care: retrospective, cross sectional, diagnostic analysis. BMJ (Clinical research ed.) (June 6). 2012. doi:10.1136/bmj.e2985.~~</ref>~~</ref><ref>Adams, D, et al. Clinical utility of an age-adjusted D-dimer in the diagnosis of venous thromboembolism. Ann Emerg Med. 2014; 64:232-234.</ref>		*Similarly, using the age adjusted d-dimer in combination with clinical probability can reduce the need for further testing in DVT evaluations with no substantial risk to patient safety<ref>Schouten, H et al.. Diagnostic accuracy of conventional or age adjusted D-dimer cut-off values in older patients with suspected venous thromboembolism: systematic review and meta-analysis. BMJ (Clinical research ed.) (May 3). 2013. doi:10.1136/bmj.f2492.</ref><ref>Schouten, H et al. Validation of two age dependent D-dimer cut-off values for exclusion of deep vein thrombosis in suspected elderly patients in primary care: retrospective, cross sectional, diagnostic analysis. BMJ (Clinical research ed.) (June 6). 2012. doi:10.1136/bmj.e2985.</ref><ref>Adams, D, et al. Clinical utility of an age-adjusted D-dimer in the diagnosis of venous thromboembolism. Ann Emerg Med. 2014; 64:232-234.</ref>

	==Usage==		==Usage==
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	==References==		==References==
	<references/>		<references/>

			[[Category:Pulmonary]]
			[[Category:Vascular]]

Ostermayer at 02:54, 2 August 2017

2017-08-02T02:54:32Z

← Older revision		Revision as of 02:54, 2 August 2017
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	==Background==		==Background==
	*The [[PE]] derivation and validation study for usage of the [[EBQ:The ADJUST-PE Study\|age adjusted d-dimer]] formula concluded that when combining the d-dimer adjustment with clinical probability, less patients required CTA for exclusion and offered no clinical increase in the rate of missed [[Pulmonary embolism]]<ref>Douma R. et al. Potential of an age adjusted D-dimer cut-off value to improve the exclusion of pulmonary embolism in older patients: a retrospective analysis of three large cohorts. BMJ (Clinical research ed.) (March 30). 2010. doi:10.1136/bmj.c1475.</ref><ref>Douma, R. et al. Using an age-dependent D-dimer cut-off value increases the number of older patients in whom deep vein thrombosis can be safely excluded. Haematologica, no. 10 (April 17). 2012. doi:10.3324/haematol.2011.060657.</ref>		*The [[PE]] derivation and validation study for usage of the [[EBQ:The ADJUST-PE Study\|age adjusted d-dimer]] formula concluded that when combining the d-dimer adjustment with clinical probability, less patients required CTA for exclusion and offered no clinical increase in the rate of missed [[Pulmonary embolism]]<ref>Douma R. et al. Potential of an age adjusted D-dimer cut-off value to improve the exclusion of pulmonary embolism in older patients: a retrospective analysis of three large cohorts. BMJ (Clinical research ed.) (March 30). 2010. doi:10.1136/bmj.c1475.</ref><ref>Douma, R. et al. Using an age-dependent D-dimer cut-off value increases the number of older patients in whom deep vein thrombosis can be safely excluded. Haematologica, no. 10 (April 17). 2012. doi:10.3324/haematol.2011.060657.</ref>
	*Similarly, using the age adjusted d-dimer in combination with clinical probability can reduce the need for further testing in DVT evaluations with no substantial risk to patient safety<ref>Schouten, H et al.. Diagnostic accuracy of conventional or age adjusted D-dimer cut-off values in older patients with suspected venous thromboembolism: systematic review and meta-analysis. BMJ (Clinical research ed.) (May 3). 2013. doi:10.1136/bmj.f2492.</ref><ref>Schouten, H et al. Validation of two age dependent D-dimer cut-off values for exclusion of deep vein thrombosis in suspected elderly patients in primary care: retrospective, cross sectional, diagnostic analysis. BMJ (Clinical research ed.) (June 6). 2012. doi:10.1136/bmj.e2985.</ref>		*Similarly, using the age adjusted d-dimer in combination with clinical probability can reduce the need for further testing in DVT evaluations with no substantial risk to patient safety<ref>Schouten, H et al.. Diagnostic accuracy of conventional or age adjusted D-dimer cut-off values in older patients with suspected venous thromboembolism: systematic review and meta-analysis. BMJ (Clinical research ed.) (May 3). 2013. doi:10.1136/bmj.f2492.</ref><ref>Schouten, H et al. Validation of two age dependent D-dimer cut-off values for exclusion of deep vein thrombosis in suspected elderly patients in primary care: retrospective, cross sectional, diagnostic analysis. BMJ (Clinical research ed.) (June 6). 2012. doi:10.1136/bmj.e2985.</ref></ref><ref>Adams, D, et al. Clinical utility of an age-adjusted D-dimer in the diagnosis of venous thromboembolism. Ann Emerg Med. 2014; 64:232-234.</ref>

	==Usage==		==Usage==

Ostermayer: /* Special Considerations */

2017-08-02T02:36:21Z

Special Considerations

← Older revision		Revision as of 02:36, 2 August 2017
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	==Special Considerations==		==Special Considerations==
			*Risk stratification for all patients should take place using the [[Wells Criteria]]
			*Know your lab's assay cutoff and whether it is report as DDU or FEUs since the formula is different for the different assays



	==References==		==References==
	<references/>		<references/>

Ostermayer: Created page with "==Background== *The PE derivation and validation study for usage of the age adjusted d-dimer formula concluded that when combining the d-dimer..."

2017-08-02T02:24:33Z

Created page with "==Background== *The PE derivation and validation study for usage of the age adjusted d-dimer formula concluded that when combining the d-dimer..."

New page

==Background==
*The [[PE]] derivation and validation study for usage of the [[EBQ:The ADJUST-PE Study|age adjusted d-dimer]] formula concluded that when combining the d-dimer adjustment with clinical probability, less patients required CTA for exclusion and offered no clinical increase in the rate of missed [[Pulmonary embolism]]<ref>Douma R. et al. Potential of an age adjusted D-dimer cut-off value to improve the exclusion of pulmonary embolism in older patients: a retrospective analysis of three large cohorts. BMJ (Clinical research ed.) (March 30). 2010. doi:10.1136/bmj.c1475.</ref><ref>Douma, R. et al. Using an age-dependent D-dimer cut-off value increases the number of older patients in whom deep vein thrombosis can be safely excluded. Haematologica, no. 10 (April 17). 2012. doi:10.3324/haematol.2011.060657.</ref>
*Similarly, using the age adjusted d-dimer in combination with clinical probability can reduce the need for further testing in DVT evaluations with no substantial risk to patient safety<ref>Schouten, H et al.. Diagnostic accuracy of conventional or age adjusted D-dimer cut-off values in older patients with suspected venous thromboembolism: systematic review and meta-analysis. BMJ (Clinical research ed.) (May 3). 2013. doi:10.1136/bmj.f2492.</ref><ref>Schouten, H et al. Validation of two age dependent D-dimer cut-off values for exclusion of deep vein thrombosis in suspected elderly patients in primary care: retrospective, cross sectional, diagnostic analysis. BMJ (Clinical research ed.) (June 6). 2012. doi:10.1136/bmj.e2985.</ref>

==Usage==
{{Age Adjusted D-dimer usage}}

{| {{table}}
| align="center" style="background:#f0f0f0;"|'''TEST'''
| align="center" style="background:#f0f0f0;"|'''Age'''
| align="center" style="background:#f0f0f0;"|'''Sensitivity'''
| align="center" style="background:#f0f0f0;"|'''Specificity'''
|-
| Lab cutoff||51 - 60||100%||57.60%
|-
| Lab cutoff ||61 - 70||99.00%||39.40%
|-
| Lab cuttoff||71 - 80||98.70%||24.50%
|-
| Lab cutoff ||>80||99.60%||14.70%
|-
| Age Adjusted cutoff||51 - 60||99.40%||62.30%
|-
| Age Adjusted cutoff ||61 - 70||97.30%||49.50%
|-
| Age Adjusted cutoff ||71 - 80||97.30%||44.20%
|-
| Age Adjusted cutoff ||>80||97.00%||35.20%
|}

==Special Considerations==

==References==
<references/>