Amitriptyline - Revision history

Arowther: /* Special Populations */

2024-06-12T03:13:18Z

Special Populations

← Older revision		Revision as of 03:13, 12 June 2024
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	*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: C		*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: C
	*[[Lactation risk categories\|Lactation risk]]: Infant risk cannot be ruled out		*[[Lactation risk categories\|Lactation risk]]: Infant risk cannot be ruled out
	*Renal dosing:		*Renal dosing: TCAs like amitryptyline don't require dose adjustment in mild or moderate renal impairment but are often avoided in kidney disease because of the increased risk for adverse cardiac side effects such as arrhythmias.
	*Hepatic dosing: use with caution		*Hepatic dosing: avoid in patients with liver failure and use with caution in those with impaired liver function, as lower doses may be required to reach therapeutic serum levels since TCAs like amitryptyline are metabolized by the liver

	==Contraindications==		==Contraindications==

ClaireLewis at 16:54, 19 September 2019

2019-09-19T16:54:21Z

← Older revision		Revision as of 16:54, 19 September 2019
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	==References==		==References==
	<references/>		<references/>
	[[Category:Pharmacology]]		[[Category:Pharmacology]] [[Category:Psychiatry]]

Humanguy: /* Mechanism of Action */

2017-10-11T19:37:17Z

Mechanism of Action

← Older revision		Revision as of 19:37, 11 October 2017
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	==Mechanism of Action==		==Mechanism of Action==
			Neurotransmitter (especially norepinephrine and serotonin) reuptake inhibitor; anticholinergic

	==Comments==		==Comments==

Humanguy: added half life and excretion

2017-10-11T19:36:22Z

added half life and excretion

← Older revision		Revision as of 19:36, 11 October 2017
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	==Pharmacology==		==Pharmacology==
	*Half-life:		*Half-life: 9 - 27 hours
	*Metabolism: Hepatic via CYP2D6		*Metabolism: Hepatic via CYP2D6
	*Excretion:		*Excretion: Urine, small amounts in feces

	==Mechanism of Action==		==Mechanism of Action==

Humanguy: added dosage forms, trade name, change route of administration terminology oral to PO

2017-10-11T19:34:58Z

added dosage forms, trade name, change route of administration terminology oral to PO

← Older revision		Revision as of 19:34, 11 October 2017
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	==Administration==		==Administration==
	*Type: [[Tricyclic antidepressant]]		*Type: [[Tricyclic antidepressant]]
	*Dosage Forms:		*Dosage Forms: tablet, injectable solution
	*Routes of Administration: ~~oral~~, IM		*Routes of Administration: PO, IM
	*Common Trade Names: Elavil		*Common Trade Names: Elavil, Levate

	==Adult Dosing==		==Adult Dosing==

ClaireLewis: Created page with "==Administration== Type: Tricyclic antidepressant Dosage Forms: Routes of Administration: oral, IM Common Trade Names: Elavil ==Adult Dosing== *50-100-300mg daily, in..."

2016-11-07T21:34:22Z

Created page with "==Administration== *Type: Tricyclic antidepressant *Dosage Forms: *Routes of Administration: oral, IM *Common Trade Names: Elavil ==Adult Dosing== *50-100-300mg daily, in..."

New page

==Administration==
*Type: [[Tricyclic antidepressant]]
*Dosage Forms:
*Routes of Administration: oral, IM
*Common Trade Names: Elavil

==Adult Dosing==
*50-100-300mg daily, in 1-3 doses

==Pediatric Dosing==
''Safety/efficacy not established in children <12yo''
*>12yo: 10mg TID and 20mg qHS

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
*[[Lactation risk categories|Lactation risk]]: Infant risk cannot be ruled out
*Renal dosing:
*Hepatic dosing: use with caution

==Contraindications==
*Allergy to class/drug
*Use of MAOIs concomitantly or within 14 days
*Recent MI
*Concomitant use of cisapride

==Adverse Reactions==
===Serious===
*Prolonged QT, dysrhythmia, MI, sudden cardiac death
*Agranulocytosis
*Hepatotoxicity
*Neuroleptic malignant syndrome
*Seizure
*Worsening depression, suicidality
===Common===
*Somnolence, dizziness
*Headache
*Constipation, xerostomia
*Blurred vision
*Weight gain

==Pharmacology==
*Half-life:
*Metabolism: Hepatic via CYP2D6
*Excretion:

==Mechanism of Action==

==Comments==

==See Also==
*[[TCA toxicity]]

==References==
<references/>
[[Category:Pharmacology]]