Anavip - Revision history

Athorne: envenomation

2021-08-02T20:58:45Z

envenomation

← Older revision		Revision as of 20:58, 2 August 2021
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	*Equine-derived F(ab')2 antibody segment targeted against the venom of North American pit viper species		*Equine-derived F(ab')2 antibody segment targeted against the venom of North American pit viper species
	*Longer half life may confer a reduced risk of recurrent subacute coagulopathy and bleeding in patients with crotaline envenomation when compared to Crofab <ref>Bush SP, Ruha AM, Seifert SA, et al. Comparison of F(ab')2 versus Fab antivenom for pit viper envenomation: a prospective, blinded, multicenter, randomized clinical trial. Clin Toxicol (Phila). 2015;53(1):37-45. doi:10.3109/15563650.2014.974263</ref>		*Longer half life may confer a reduced risk of recurrent subacute coagulopathy and bleeding in patients with crotaline envenomation when compared to Crofab <ref>Bush SP, Ruha AM, Seifert SA, et al. Comparison of F(ab')2 versus Fab antivenom for pit viper envenomation: a prospective, blinded, multicenter, randomized clinical trial. Clin Toxicol (Phila). 2015;53(1):37-45. doi:10.3109/15563650.2014.974263</ref>

			==Indications==
			*Progression of swelling
			*Abnormal results on lab tests (platelets < 100,000 or fibrinogen < 100)
			*Systemic manifestations (unstable vitals or altered mental status)

	==Administration==		==Administration==

2021-08-02T20:56:50Z

Comments

← Older revision		Revision as of 20:56, 2 August 2021
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	==Mechanism of Action==		==Mechanism of Action==
	*Contains venom-specific F(ab’)2 fragments of immunoglobulin G (IgG) that bind and neutralize venom toxins of North American pit vipers		*Contains venom-specific F(ab’)2 fragments of immunoglobulin G (IgG) that bind and neutralize venom toxins of North American pit vipers

	~~==Comments==~~


	==See Also==		==See Also==

2021-08-02T20:13:10Z

2021-08-02T20:11:43Z

Background

← Older revision		Revision as of 20:11, 2 August 2021
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	==Background==		==Background==
	*Equine-derived F(ab')2 antibody segment targeted against the venom of North American pit viper species		*Equine-derived F(ab')2 antibody segment targeted against the venom of North American pit viper species
	*~~May reduce the~~ risk of recurrent subacute coagulopathy and bleeding in patients with crotaline envenomation when compared to Crofab <ref>Bush SP, Ruha AM, Seifert SA, et al. Comparison of F(ab')2 versus Fab antivenom for pit viper envenomation: a prospective, blinded, multicenter, randomized clinical trial. Clin Toxicol (Phila). 2015;53(1):37-45. doi:10.3109/15563650.2014.974263</ref>		*Longer half life may confer a reduced risk of recurrent subacute coagulopathy and bleeding in patients with crotaline envenomation when compared to Crofab <ref>Bush SP, Ruha AM, Seifert SA, et al. Comparison of F(ab')2 versus Fab antivenom for pit viper envenomation: a prospective, blinded, multicenter, randomized clinical trial. Clin Toxicol (Phila). 2015;53(1):37-45. doi:10.3109/15563650.2014.974263</ref>

	==Administration==		==Administration==

2021-08-02T20:11:01Z

← Older revision		Revision as of 20:11, 2 August 2021
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			==Background==
			*Equine-derived F(ab')2 antibody segment targeted against the venom of North American pit viper species
			*May reduce the risk of recurrent subacute coagulopathy and bleeding in patients with crotaline envenomation when compared to Crofab <ref>Bush SP, Ruha AM, Seifert SA, et al. Comparison of F(ab')2 versus Fab antivenom for pit viper envenomation: a prospective, blinded, multicenter, randomized clinical trial. Clin Toxicol (Phila). 2015;53(1):37-45. doi:10.3109/15563650.2014.974263</ref>

	==Administration==		==Administration==
	*[[Crotaline (Pit Vipers)]] equine immune F(ab')2 antivenom		*[[Crotaline (Pit Vipers)]] equine immune F(ab')2 antivenom

2021-08-02T20:06:42Z

Mechanism of Action

← Older revision		Revision as of 20:06, 2 August 2021
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	==Mechanism of Action==		==Mechanism of Action==
			*Contains venom-specific F(ab’)2 fragments of immunoglobulin G (IgG) that bind and neutralize venom toxins of North American pit vipers

	==Comments==		==Comments==

2021-08-02T20:05:40Z

Pharmacology

← Older revision		Revision as of 20:05, 2 August 2021
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	*The most common reported side effects in clinical trials include: pruritis, rash, arthralgia, and nausea <ref>FDA Package Insert - ANAVIP https://www.fda.gov/media/92139/download</ref>		*The most common reported side effects in clinical trials include: pruritis, rash, arthralgia, and nausea <ref>FDA Package Insert - ANAVIP https://www.fda.gov/media/92139/download</ref>

	==Pharmacology==		==Pharmacology<ref>Crotalinae (pit viper) equine immune F(ab')2 antivenom: Drug information. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. (Accessed on August 02, 2021.)</ref>==
	*Half-life:		*Half-life: 5.5 days
	*Metabolism:		*Metabolism: unknown
	*Excretion:

	==Mechanism of Action==		==Mechanism of Action==

2021-08-02T20:03:52Z

Adult Dosing

← Older revision		Revision as of 20:03, 2 August 2021
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	*Common Trade Names: Anavip		*Common Trade Names: Anavip

	==Adult Dosing==		==Adult Dosing<ref>FDA Package Insert - ANAVIP https://www.fda.gov/media/92139/download</ref>==
	*Administer as soon as possible following North American Pit Viper bite with signs of envenomation.		*Administer as soon as possible following North American Pit Viper bite with signs of envenomation.
	===Initial Loading Dose===		===Initial Loading Dose===

2021-08-02T20:03:22Z

Adverse Reactions

← Older revision		Revision as of 20:03, 2 August 2021
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	==Adverse Reactions==		==Adverse Reactions==
	~~===Serious===~~		*The most common reported side effects in clinical trials include: pruritis, rash, arthralgia, and nausea <ref>FDA Package Insert - ANAVIP https://www.fda.gov/media/92139/download</ref>


	~~===Common===~~


	==Pharmacology==		==Pharmacology==

2021-08-02T19:58:25Z

Pregnancy Rating

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	==Special Populations==		==Special Populations==
	===[[Drug pregnancy categories\|Pregnancy Rating]]===		===[[Drug pregnancy categories\|Pregnancy Rating]]===
	*		*No known Pregnancy category
			*In general, antidotes should not be withheld if indicated for treatment of the mother for fears of teratogenicity.

	===Lactation risk===		===Lactation risk===