Anemia of spaceflight - Revision history

Rossdonaldson1: /* See Also */

2024-11-06T16:28:12Z

Rossdonaldson1: /* Differential Diagnosis */

2024-07-17T20:06:19Z

Differential Diagnosis

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	==Differential Diagnosis==		==Differential Diagnosis==
			{{Space medicine}}
	{{Anemia DDX}}		{{Anemia DDX}}

Ostermayer: Ostermayer moved page Anemia of space to Anemia of spaceflight: renaming

2024-05-02T05:16:27Z

Ostermayer moved page Anemia of space to Anemia of spaceflight: renaming

← Older revision	Revision as of 05:16, 2 May 2024
(No difference)

Ostermayer: /* Disposition */

2024-05-02T04:31:28Z

Disposition

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	==Management==		==Management==


	~~==Disposition==~~

Ostermayer: /* Evaluation */

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Evaluation

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	==Evaluation==		==Evaluation==
			*Upon return to earth, compensatory fluid shifts may temporarily exacerbate anemia via dilution.<ref>Leach, C. S. & Johnson, P. C. Influence of spaceflight on erythrokinetics in man. Science 225, 216–218 (1984).</ref>
	===Workup===		===Workup===
			*CBC
	===Diagnosis===		===Diagnosis===

Ostermayer: /* Background */

2024-05-02T03:59:13Z

Background

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	*Reports describe from 10% to 15% of Hb decrease from preflight levels within 10 to 14 days of space flight<ref>LeBlanc A, Schneider V, Shackelford L, et al. Bone mineral and lean tissue loss after long duration space flight. J Musculoskel Neuron Interact 2000; 1(2):157–160</ref><ref>Lang T, LeBlanc A, Evans H, Lu Y, Genant H, Yu A. Cortical and trabecular bone mineral loss from the spine and hip in long duration spaceflight. J Bone Miner Res 2004; 19(6):1006–1012.</ref>		*Reports describe from 10% to 15% of Hb decrease from preflight levels within 10 to 14 days of space flight<ref>LeBlanc A, Schneider V, Shackelford L, et al. Bone mineral and lean tissue loss after long duration space flight. J Musculoskel Neuron Interact 2000; 1(2):157–160</ref><ref>Lang T, LeBlanc A, Evans H, Lu Y, Genant H, Yu A. Cortical and trabecular bone mineral loss from the spine and hip in long duration spaceflight. J Bone Miner Res 2004; 19(6):1006–1012.</ref>

	*The Anemia may develop due to one or more of the following processes:<ref>		The Anemia may develop due to one or more of the following processes:<ref>
	3. Udden MM, Driscoll TB, Pickett MH, Leach-Huntoon CS, Alfrey CP. Decreased production of red blood cells in human subjects exposed to microgravity. J Lab Clin Med. 1995;125(4):442-449.</ref><ref>Tavassoli M. Anemia of spaceflight. Blood. 1982;60(5):1059-1067.</ref>		3. Udden MM, Driscoll TB, Pickett MH, Leach-Huntoon CS, Alfrey CP. Decreased production of red blood cells in human subjects exposed to microgravity. J Lab Clin Med. 1995;125(4):442-449.</ref><ref>Tavassoli M. Anemia of spaceflight. Blood. 1982;60(5):1059-1067.</ref>
	**Poor erythrocyte production or marrow dysfunction		*Poor erythrocyte production or marrow dysfunction
	**~~low~~ EPO levels		*Fluid Shifts
	**Abnormally-shaped erythrocytes		**Fluid distributes to a greater extent in the upper body and this distends the carotid and aortic baroreceptors giving the false signal of "volume overload"<ref>Iwase S., Nishimura N., Tanaka K., Mano T. (2020). “Effects of microgravity on human physiology,” in Beyond LEO - human health issues for deep space exploration. Editor Reynolds R. J. (London, UK: Intech Open; ), 1–22. 10.5772/intechopen.90700</ref>
	**Splenic sequestration		*Low EPO levels
	**Shortened RBC lifespan.		*Abnormally-shaped erythrocytes
			*Splenic sequestration
			*Shortened RBC lifespan.

	==Clinical Features==		==Clinical Features==

Rossdonaldson1: Rossdonaldson1 moved page Anemia of Space to Anemia of space

2024-05-01T15:18:17Z

Rossdonaldson1 moved page Anemia of Space to Anemia of space

← Older revision	Revision as of 15:18, 1 May 2024
(No difference)

Ostermayer: /* Background */

2024-04-30T11:44:28Z

Background

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	**Abnormally-shaped erythrocytes		**Abnormally-shaped erythrocytes
	**Splenic sequestration		**Splenic sequestration
	*Shortened RBC lifespan.		**Shortened RBC lifespan.

	==Clinical Features==		==Clinical Features==

Ostermayer: /* Background */

2024-04-30T11:44:15Z

Background

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	*Reports describe from 10% to 15% of Hb decrease from preflight levels within 10 to 14 days of space flight<ref>LeBlanc A, Schneider V, Shackelford L, et al. Bone mineral and lean tissue loss after long duration space flight. J Musculoskel Neuron Interact 2000; 1(2):157–160</ref><ref>Lang T, LeBlanc A, Evans H, Lu Y, Genant H, Yu A. Cortical and trabecular bone mineral loss from the spine and hip in long duration spaceflight. J Bone Miner Res 2004; 19(6):1006–1012.</ref>		*Reports describe from 10% to 15% of Hb decrease from preflight levels within 10 to 14 days of space flight<ref>LeBlanc A, Schneider V, Shackelford L, et al. Bone mineral and lean tissue loss after long duration space flight. J Musculoskel Neuron Interact 2000; 1(2):157–160</ref><ref>Lang T, LeBlanc A, Evans H, Lu Y, Genant H, Yu A. Cortical and trabecular bone mineral loss from the spine and hip in long duration spaceflight. J Bone Miner Res 2004; 19(6):1006–1012.</ref>

	~~===Mechanism~~ of ~~Action===~~		*The Anemia may develop due to one or more of the following processes:<ref>
			3. Udden MM, Driscoll TB, Pickett MH, Leach-Huntoon CS, Alfrey CP. Decreased production of red blood cells in human subjects exposed to microgravity. J Lab Clin Med. 1995;125(4):442-449.</ref><ref>Tavassoli M. Anemia of spaceflight. Blood. 1982;60(5):1059-1067.</ref>
			**Poor erythrocyte production or marrow dysfunction
			**low EPO levels
			**Abnormally-shaped erythrocytes
			**Splenic sequestration
			*Shortened RBC lifespan.

	==Clinical Features==		==Clinical Features==

Ostermayer: /* Background */

2024-04-30T06:26:57Z

Background

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	==Background==		==Background==
	The anemia of space flight (1% Hb loss per day)<ref>Leach CS, Johnson PC. Influence of spaceflight on erythrokinetics in man. Science. 1984;225(4658):216-218.</ref><ref>Udden MM, Driscoll TB, Pickett MH, Leach-Huntoon CS, Alfrey CP. Decreased production of red blood cells in human subjects exposed to microgravity. J Lab Clin Med. 1995;125(4):442-449.</ref><ref>Alfrey CP, Udden MM, Leach-Huntoon C, Driscoll T, Pickett MH. Control of red blood cell mass in spaceflight. J Appl Physiol. 1996; 81(1):98-104.</ref> It was first described in relation to the Gemini astronauts.<ref> Fischer CL, Johnson PC, Berry CA. Red blood cell mass and plasma volume changes in manned space flight. JAMA. 1967;200(7): 579-583.</ref>		The anemia of space flight (1% Hb loss per day)<ref>Leach CS, Johnson PC. Influence of spaceflight on erythrokinetics in man. Science. 1984;225(4658):216-218.</ref><ref>Udden MM, Driscoll TB, Pickett MH, Leach-Huntoon CS, Alfrey CP. Decreased production of red blood cells in human subjects exposed to microgravity. J Lab Clin Med. 1995;125(4):442-449.</ref><ref>Alfrey CP, Udden MM, Leach-Huntoon C, Driscoll T, Pickett MH. Control of red blood cell mass in spaceflight. J Appl Physiol. 1996; 81(1):98-104.</ref> It was first described in relation to the Gemini astronauts.<ref> Fischer CL, Johnson PC, Berry CA. Red blood cell mass and plasma volume changes in manned space flight. JAMA. 1967;200(7): 579-583.</ref>
	*Reports describe from 10% to 15% of Hb decrease from preflight levels within 10 to 14 days of space flight<ref>LeBlanc A, Schneider V, Shackelford L, et al. Bone mineral and lean tissue loss after long duration space flight. J Musculoskel Neuron Interact 2000; 1(2):157–160</ref>,ref>Lang T, LeBlanc A, Evans H, Lu Y, Genant H, Yu A. Cortical and trabecular bone mineral loss from the spine and hip in long duration spaceflight. J Bone Miner Res 2004; 19(6):1006–1012.</ref>		*Reports describe from 10% to 15% of Hb decrease from preflight levels within 10 to 14 days of space flight<ref>LeBlanc A, Schneider V, Shackelford L, et al. Bone mineral and lean tissue loss after long duration space flight. J Musculoskel Neuron Interact 2000; 1(2):157–160</ref><ref>Lang T, LeBlanc A, Evans H, Lu Y, Genant H, Yu A. Cortical and trabecular bone mineral loss from the spine and hip in long duration spaceflight. J Bone Miner Res 2004; 19(6):1006–1012.</ref>

	===Mechanism of Action===		===Mechanism of Action===

← Older revision		Revision as of 16:28, 6 November 2024
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	==See Also==		==See Also==
			*[[Space medicine]]

	==External Links==		==External Links==