Anticonvulsant levels and reloading - Revision history

Elcatracho: /* Background */

2021-03-08T03:59:20Z

Background

← Older revision		Revision as of 03:59, 8 March 2021
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	==Background==		==Background==
	*IV load can be performed with phenobarbital, [[phenytoin]], valproate, levetiracetam		*IV load can be performed with [[phenobarbital]], [[phenytoin]], [[valproate]], [[levetiracetam]]
	*Oral loading can be spread over day or more to avoid GI upset		*Oral loading can be spread over day or more to avoid GI upset
	*May use IV vs PO reload at physican discretion<ref name="ACEP">Seizures ACEP Policy committee . Clinical Policy: Critical Issues in the Evaluation and Management of Adult Patients Presenting to the Emergency Department With Seizures. Ann Emerg Med. 2014;63(4):437–447.e15. doi:10.1016/j.annemergmed.2014.01.018.</ref>		*May use IV vs PO reload at physican discretion<ref name="ACEP">Seizures ACEP Policy committee . Clinical Policy: Critical Issues in the Evaluation and Management of Adult Patients Presenting to the Emergency Department With Seizures. Ann Emerg Med. 2014;63(4):437–447.e15. doi:10.1016/j.annemergmed.2014.01.018.</ref>

2019-09-27T15:25:23Z

Reloading

← Older revision		Revision as of 15:25, 27 September 2019
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	==Reloading==		==Reloading==
	*'''Dose (mg) = ideal body weight (kg) X Vd X [desired level - current level (mcg/mL)]'''		*'''Dose (mg) = [[ideal body weight estimation\|ideal body weight]] (kg) X Vd X [desired level - current level (mcg/mL)]'''

	===Volume of Distribution===		===Volume of Distribution===

2018-11-10T02:17:33Z

Initial Loading

2016-08-03T07:15:49Z

Text replacement - " phenytoin" to " phenytoin"

← Older revision		Revision as of 07:15, 3 August 2016
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	==Background==		==Background==
	*IV load can be performed with phenobarbital, phenytoin, valproate, levetiracetam		*IV load can be performed with phenobarbital, [[phenytoin]], valproate, levetiracetam
	*Oral loading can be spread over day or more to avoid GI upset		*Oral loading can be spread over day or more to avoid GI upset
	*May use IV vs PO reload at physican discretion<ref name="ACEP">Seizures ACEP Policy committee . Clinical Policy: Critical Issues in the Evaluation and Management of Adult Patients Presenting to the Emergency Department With Seizures. Ann Emerg Med. 2014;63(4):437–447.e15. doi:10.1016/j.annemergmed.2014.01.018.</ref>		*May use IV vs PO reload at physican discretion<ref name="ACEP">Seizures ACEP Policy committee . Clinical Policy: Critical Issues in the Evaluation and Management of Adult Patients Presenting to the Emergency Department With Seizures. Ann Emerg Med. 2014;63(4):437–447.e15. doi:10.1016/j.annemergmed.2014.01.018.</ref>

2016-07-19T02:46:15Z

Text replacement - "0 mg" to "0mg"

← Older revision		Revision as of 02:46, 19 July 2016
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	\|-		\|-
	\| [[Gabapentin]] (Neurontin)		\| [[Gabapentin]] (Neurontin)
	\|~~900 mg~~/day oral (~~300 mg~~ tid) for 3 days		\|900mg/day oral (300mg tid) for 3 days
	\|NA		\|NA
	\|-		\|-
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	\|-		\|-
	\| [[Levetiracetam]] (Keppra)		\| [[Levetiracetam]] (Keppra)
	\|1,~~500 mg~~ oral load		\|1,500mg oral load
	\|Up to ~~60 mg~~/kg (rapid loading)		\|Up to 60mg/kg (rapid loading)
	\|-		\|-
	\| [[Phenytoin]] (Dilantin)		\| [[Phenytoin]] (Dilantin)
	\|~~20 mg~~/kg divided in maximum doses of ~~400 mg~~ every 2 hours		\|20mg/kg divided in maximum doses of 400mg every 2 hours
	\|18mg/kg (max rate of ~~50 mg~~/min)		\|18mg/kg (max rate of 50mg/min)
	\|-		\|-
	\|[[Fosphenytoin]] (Cerebyx)		\|[[Fosphenytoin]] (Cerebyx)
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	\| [[Valproate]] (Depacon)		\| [[Valproate]] (Depacon)
	\|NA		\|NA
	\|Up to ~~30 mg~~/kg IV (max rate of ~~10 mg~~/kg/min)		\|Up to 30mg/kg IV (max rate of 10mg/kg/min)
	\|}		\|}

2016-07-18T22:12:02Z

Text replacement - "8 mg" to "8mg"

← Older revision		Revision as of 22:12, 18 July 2016
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	\|-		\|-
	\| [[Carbamazepine]] (Tegretol)		\| [[Carbamazepine]] (Tegretol)
	\|~~8 mg~~/kg suspension in single oral load		\|8mg/kg suspension in single oral load
	\|NA		\|NA
	\|-		\|-
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	\| [[Phenytoin]] (Dilantin)		\| [[Phenytoin]] (Dilantin)
	\|20 mg/kg divided in maximum doses of 400 mg every 2 hours		\|20 mg/kg divided in maximum doses of 400 mg every 2 hours
	\|~~18 mg~~/kg (max rate of 50 mg/min)		\|18mg/kg (max rate of 50 mg/min)
	\|-		\|-
	\|[[Fosphenytoin]] (Cerebyx)		\|[[Fosphenytoin]] (Cerebyx)

2016-07-18T22:01:09Z

Text replacement - "5 mg" to "5mg"

← Older revision		Revision as of 22:01, 18 July 2016
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	\|-		\|-
	\| [[Lamotrigine]] (Lamictal)		\| [[Lamotrigine]] (Lamictal)
	\|6.~~5 mg~~/kg single oral load if on lamotrigine for >6 mo without a history of rash or intolerance in the past and only off lamotrigine for <5 days		\|6.5mg/kg single oral load if on lamotrigine for >6 mo without a history of rash or intolerance in the past and only off lamotrigine for <5 days
	\|NA		\|NA
	\|-		\|-

2016-04-03T08:55:38Z

← Older revision	Revision as of 08:55, 3 April 2016
(No difference)

2016-04-03T08:54:32Z

← Older revision		Revision as of 08:54, 3 April 2016
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	== Background ==		==Background==
	*IV load can be performed with phenobarbital, phenytoin, valproate, levetiracetam		*IV load can be performed with phenobarbital, phenytoin, valproate, levetiracetam
	*Oral loading can be spread over day or more to avoid GI upset		*Oral loading can be spread over day or more to avoid GI upset
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	==Reloading==		==Reloading==
	'''Dose (mg) = ideal body weight (kg) X Vd X [desired level - current level (mcg/mL)]'''		*'''Dose (mg) = ideal body weight (kg) X Vd X [desired level - current level (mcg/mL)]'''

	=== Volume of Distribution ===		===Volume of Distribution===

	{\| class="wikitable"		{\| class="wikitable"
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	==See Also==		==See Also==
	*[[Seizure]]		*[[Seizure]]
	*[[Seizure (~~Peds~~)]]		*[[Seizure (peds)]]
	*[[Seizure with known seizure disorder]]		*[[Seizure with known seizure disorder]]
	*[[Anticonvulsants]]		*[[Anticonvulsants]]

2016-03-22T15:53:44Z

Text replacement - "Category:Drugs" to "Category:Pharmacology"