Autoimmune hepatitis - Revision history

Ostermayer: Marked this version for translation

2026-01-06T21:18:13Z

Marked this version for translation

← Older revision		Revision as of 21:18, 6 January 2026
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	<translate>		<translate>

	==Background==		==Background== <!--T:1-->

			<!--T:2-->
	*Hepatocellular inflammation caused by autoimmune pathology, ultimately leading to necrosis and cirrhosis		*Hepatocellular inflammation caused by autoimmune pathology, ultimately leading to necrosis and cirrhosis
	*Presentation may be acute or chronic, rarely presents as fulminant [[Special:MyLanguage/hepatic failure\|hepatic failure]]		*Presentation may be acute or chronic, rarely presents as fulminant [[Special:MyLanguage/hepatic failure\|hepatic failure]]
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	==Clinical Features==		==Clinical Features== <!--T:3-->

			<!--T:4-->
	[[File:Jaundice08.jpg\|thumb\|Jaundice of the skin]]		[[File:Jaundice08.jpg\|thumb\|Jaundice of the skin]]
	[[File:Jaundice.jpg\|thumb\|Pediatric jaundice with icterus of sclera.]]		[[File:Jaundice.jpg\|thumb\|Pediatric jaundice with icterus of sclera.]]
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	==Differential Diagnosis==		==Differential Diagnosis== <!--T:5-->

			<!--T:6-->
	*[[Special:MyLanguage/Viral hepatitis\|Viral hepatitis]]		*[[Special:MyLanguage/Viral hepatitis\|Viral hepatitis]]
	*[[Special:MyLanguage/Acute alcoholic hepatitis\|Acute alcoholic hepatitis]], alcoholic liver disease		*[[Special:MyLanguage/Acute alcoholic hepatitis\|Acute alcoholic hepatitis]], alcoholic liver disease
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	==Evaluation==		==Evaluation== <!--T:7-->


	===Workup===		===Workup=== <!--T:8-->

			<!--T:9-->
	*[[Special:MyLanguage/LFTs\|LFTs]]		*[[Special:MyLanguage/LFTs\|LFTs]]
	**ALT/AST 1.5-50 times normal		**ALT/AST 1.5-50 times normal
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	===Diagnosis===		===Diagnosis=== <!--T:10-->

			<!--T:11-->
	*Evaluate for other causes of liver disease, if not previously diagnosed with autoimmune hepatitis:		*Evaluate for other causes of liver disease, if not previously diagnosed with autoimmune hepatitis:
	**[[Special:MyLanguage/Viral hepatitis\|Viral hepatitis]] serologies		**[[Special:MyLanguage/Viral hepatitis\|Viral hepatitis]] serologies
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	==Management==		==Management== <!--T:12-->

			<!--T:13-->
	*[[Special:MyLanguage/Corticosteroids\|Corticosteroids]] +/- [[Special:MyLanguage/Azathioprine\|Azathioprine]]		*[[Special:MyLanguage/Corticosteroids\|Corticosteroids]] +/- [[Special:MyLanguage/Azathioprine\|Azathioprine]]
	*Manage complications, see:		*Manage complications, see:
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	==Disposition==		==Disposition== <!--T:14-->


	==See Also==		==See Also== <!--T:15-->

			<!--T:16-->
	*[[Special:MyLanguage/Acute hepatitis\|Acute hepatitis]]		*[[Special:MyLanguage/Acute hepatitis\|Acute hepatitis]]
	*[[Special:MyLanguage/Cirrhosis\|Cirrhosis]]		*[[Special:MyLanguage/Cirrhosis\|Cirrhosis]]


	==External Links==		==External Links== <!--T:17-->


	==References==		==References== <!--T:18-->

			<!--T:19-->
	<references/>		<references/>

			<!--T:20-->
	[[Category:GI]]		[[Category:GI]]
	</translate>		</translate>

Ostermayer: Prepared the page for translation

2026-01-04T21:42:48Z

Prepared the page for translation

Show changes

Rossdonaldson1: /* Clinical Features */

2024-02-28T20:22:28Z

Clinical Features

← Older revision		Revision as of 20:22, 28 February 2024
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	==Clinical Features==		==Clinical Features==
			[[File:Jaundice08.jpg\|thumb\|Jaundice of the skin]]
			[[File:Jaundice.jpg\|thumb\|Pediatric jaundice with icterus of sclera.]]
	''Findings of liver disease and systemic signs/symptoms of autoimmune disorders''		''Findings of liver disease and systemic signs/symptoms of autoimmune disorders''
	*[[Nausea/vomiting]], diarrhea		*[[Nausea/vomiting]], diarrhea

Rossdonaldson1: /* Differential Diagnosis */

2022-09-07T21:23:17Z

Differential Diagnosis

← Older revision		Revision as of 21:23, 7 September 2022
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	*[[Sarcoidosis]]		*[[Sarcoidosis]]

			{{Acute hepatitis causes}}
	{{Hepatomegaly DDX}}		{{Hepatomegaly DDX}}

Rossdonaldson1: /* Differential Diagnosis */

2022-09-07T20:51:29Z

Differential Diagnosis

← Older revision		Revision as of 20:51, 7 September 2022
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	*[[Wilson's disease]]		*[[Wilson's disease]]
	*[[Sarcoidosis]]		*[[Sarcoidosis]]

			{{Hepatomegaly DDX}}

	==Evaluation==		==Evaluation==

Rossdonaldson1: /* Evaluation */

2022-09-07T18:09:45Z

Evaluation

← Older revision		Revision as of 18:09, 7 September 2022
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	==Evaluation==		==Evaluation==
			===Workup===
	*[[LFTs]]		*[[LFTs]]
	**ALT/AST 1.5-50 times normal		**ALT/AST 1.5-50 times normal
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	*Ammonia if suspect [[hepatic encephalopathy]]		*Ammonia if suspect [[hepatic encephalopathy]]
	*[[Paracentesis]] if suspect [[SBP]]		*[[Paracentesis]] if suspect [[SBP]]
	*~~Autoantibodies: may have positive ANA, SMA, LKM-1,~~ and/or anti-LC1<ref>http://emedicine.medscape.com/article/172356-overview</ref> ; ANA & SMA usually positive in type 1 autoimmune hepatitis, LJM-1 and atypical p-ANCA positive in type 2 and liver soluble antigen usually in type 3		*Consider [[RUQ ultrasound]] and/or MRCP

			===Diagnosis===
	*Evaluate for other causes of liver disease, if not previously diagnosed with autoimmune hepatitis:		*Evaluate for other causes of liver disease, if not previously diagnosed with autoimmune hepatitis:
	**[[Viral hepatitis]] serologies		**[[Viral hepatitis]] serologies
	**[[Acetaminophen]] level		**[[Acetaminophen]] level
	*~~Consider [[RUQ ultrasound]]~~ and/or ~~MRCP~~		*Autoantibodies: may have positive ANA, SMA, LKM-1, and/or anti-LC1<ref>http://emedicine.medscape.com/article/172356-overview</ref> ; ANA & SMA usually positive in type 1 autoimmune hepatitis, LJM-1 and atypical p-ANCA positive in type 2 and liver soluble antigen usually in type 3
	*Definitive diagnosis usually by liver biopsy		*Definitive diagnosis usually by liver biopsy

Kfarzam: /* Management */

2022-08-18T07:05:16Z

Management

← Older revision		Revision as of 07:05, 18 August 2022
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	**[[Hepatic encephalopathy]]		**[[Hepatic encephalopathy]]
	*Ultimately, may require transplant		*Ultimately, may require transplant
			*Hepatology/Gastroenterology consult should be made

	==Disposition==		==Disposition==

Kfarzam: /* Evaluation */

2022-08-18T07:04:42Z

Evaluation

← Older revision		Revision as of 07:04, 18 August 2022
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	*Ammonia if suspect [[hepatic encephalopathy]]		*Ammonia if suspect [[hepatic encephalopathy]]
	*[[Paracentesis]] if suspect [[SBP]]		*[[Paracentesis]] if suspect [[SBP]]
	*Autoantibodies: may have positive ANA, SMA, LKM-1, and/or anti-LC1<ref>http://emedicine.medscape.com/article/172356-overview</ref>		*Autoantibodies: may have positive ANA, SMA, LKM-1, and/or anti-LC1<ref>http://emedicine.medscape.com/article/172356-overview</ref> ; ANA & SMA usually positive in type 1 autoimmune hepatitis, LJM-1 and atypical p-ANCA positive in type 2 and liver soluble antigen usually in type 3
	*Evaluate for other causes of liver disease, if not previously diagnosed with autoimmune hepatitis:		*Evaluate for other causes of liver disease, if not previously diagnosed with autoimmune hepatitis:
	**[[Viral hepatitis]] serologies		**[[Viral hepatitis]] serologies
	**[[Acetaminophen]] level		**[[Acetaminophen]] level
	*Consider [[RUQ ultrasound]]		*Consider [[RUQ ultrasound]] and/or MRCP
	*Definitive diagnosis usually by liver biopsy		*Definitive diagnosis usually by liver biopsy

Kfarzam: /* Differential Diagnosis */

2022-08-18T07:03:23Z

Differential Diagnosis

← Older revision		Revision as of 07:03, 18 August 2022
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	*[[Non-alcoholic steatohepatitis]]		*[[Non-alcoholic steatohepatitis]]
	*Cardiac cirrhosis		*Cardiac cirrhosis
	*Primary biliary cirrhosis, [[primary sclerosing cholangitis]]		*Primary biliary cirrhosis
			*[[primary sclerosing cholangitis]]
	*[[Budd-Chiari]]		*[[Budd-Chiari]]
	*Alpha1 anti-trypsin Deficiency		*Alpha1 anti-trypsin Deficiency
	*[[Cystic Fibrosis]]		*[[Cystic Fibrosis]]
			*[[Wilson's disease]]
			*[[Sarcoidosis]]

	==Evaluation==		==Evaluation==

Kfarzam: /* Background */

2022-08-18T07:02:02Z

Background

← Older revision		Revision as of 07:02, 18 August 2022
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	*Usually affects women (~70%<ref>http://www.liverfoundation.org/abouttheliver/info/aihep/</ref> between age 15-40 years		*Usually affects women (~70%<ref>http://www.liverfoundation.org/abouttheliver/info/aihep/</ref> between age 15-40 years
	*Often occurs comorbidly with other autoimmune disorders (e.g. type 1 [[diabetes]], [[thyroid disease]], [[inflammatory bowel disease]], [[Sjögren]]'s)		*Often occurs comorbidly with other autoimmune disorders (e.g. type 1 [[diabetes]], [[thyroid disease]], [[inflammatory bowel disease]], [[Sjögren]]'s)
			*3 subtypes of autoimmune hepatitis: types 1-3, with type 1 being the most common

	==Clinical Features==		==Clinical Features==