Behcet's disease - Revision history

ClaireLewis: Redirected page to Behçet's disease

2017-08-17T04:46:38Z

← Older revision		Revision as of 04:46, 17 August 2017
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	~~==Background==~~		#REDIRECT[[Behçet's disease]]
	[[~~File:Behcet~~'s~~.png\|thumb\|]]~~
	*Chronic small-vessel [[vasculitis]]
	*Mucocutaneous, ocular, cardiovascular, renal, GI, pulmonary, urologic, musculoskeletal, CNS involvement
	*Aphthous oral ulcers + ≥ 2 of following: Genital aphthae, cutaneous lesions, and neurological, oral or rheumatologic manifestations

	~~==Clinical Features==~~
	*Age 20-30s most commonly
	*More common in Turkey, Japan, Middle East
	*Triad: Recurrent oral aphthous ulcers, genital ulcers, and [[uveitis]]
	*Classically painful ulcer with necrotic center and red rim
	*Skin: Subcutaneous nodules, pyoderma gangrenosum, cutaneous thrombophlebitis, pustular acne-like folliculitis
	*Ocular: [[Uveitis]], iritis, [[optic neuritis]], [[vision loss]], hypopyon
	*Neurologic: Brainstem and corticospinal tract syndromes, aseptic [[meningoencephalitis]], [[increased ICP]], [[cerebral sinus thrombosis]], optic nerve ischemia
	*GI: Ulcers, obstruction, ileocecal perforation
	*Inflammatory oligo[[arthritis]]
	*Vasculopathy: Aneurysm, [[vasculitis]], superficial [[thrombophlebitis]], thrombosis
	*Cardiac: [[Myocarditis]], [[endocarditis]], [[pericarditis]]
	*Renal: [[Glomerulonephritis]], amyloidosis
	*Pulmonary: [[Pleural effusions]], [[pulmonary hypertension]], pulmonary aneurysm

	~~==Differential Diagnosis==~~
	*[[HSV]]
	*[[lichen planus]]
	*[[pemphigus vulgaris]]
	*[[pemphigoid]]
	*IVD
	*[[SJS]]
	*celiac disease
	*[[SLE]]
	*[[Sjogren's]]
	*[[MS]]
	*[[Sarcoidosis]]
	*[[Syphilis]]
	*[[TB]]
	*malignancy
	*[[Reactive arthritis]]
	*[[HIV]]
	*Other [[vasculitis syndromes]]

	~~==Evaluation==~~
	*Clinical diagnosis
	*ESR/CRP elevated

	~~===Classification===~~
	*International Study Group Criteria
	*Recurrent oral aphthae (at least 3 times in 1 year) + 2 of the following in absence of other systemic diseases:
	**Recurrent genital aphthae
	**Eye lesions
	**Skin lesions
	**A positive pathery test

	~~==Management==~~
	*Rheumatology consult +/- multidisciplinary consults
	*Oral and genital ulcers: [[Topical steroids]]
	*Severe mucocutaneous disease~~: [[Prednisone]] 1mg/kg, low-dose thalidomide, or methotrexate~~
	*Systemic disease: Steroid +/- [[cyclophosphamide]] or [[azathioprine]]
	*Ocular: Prednisone + azathioprine and rapid ophthalmologist referral
	*Cerebral [[venous sinus thrombosis]]- [[heparin]]

	~~==References==~~
	~~<references/>~~
	*Rosen's Emergency Medicine 8th edition. 2013. Chapter: Erythematosus and the Vasculitides. p1540.
	*Smith EL, et al. Clinical manifestations and diagnosis of Behcet's disease. In: Post T, ed. UpToDate. Waltham, Mass.: UpToDate; 2014. www.uptodate.com. Accessed December 22, 2014.
	*Alnaimat FA, et al. (2014, Dec 16). Behcet Disease. eMedicine. Retrieved 12/22/2014 from http://emedicine.medscape.com/article/329099-overview

	~~[[Category:Rheumatology~~]]

ClaireLewis at 23:12, 13 November 2016

2016-11-13T23:12:09Z

← Older revision		Revision as of 23:12, 13 November 2016
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	==Background==		==Background==
	[[File:Behcet's.png\|thumb\|]]		[[File:Behcet's.png\|thumb\|]]
	*Chronic small-vessel vasculitis		*Chronic small-vessel [[vasculitis]]
	*Mucocutaneous, ocular, cardiovascular, renal, GI, pulmonary, urologic, musculoskeletal, CNS involvement		*Mucocutaneous, ocular, cardiovascular, renal, GI, pulmonary, urologic, musculoskeletal, CNS involvement
	*Aphthous oral ulcers + ≥ 2 of following: Genital aphthae, cutaneous lesions, and neurological, oral or rheumatologic manifestations		*Aphthous oral ulcers + ≥ 2 of following: Genital aphthae, cutaneous lesions, and neurological, oral or rheumatologic manifestations

	==Clinical Features==		==Clinical Features==
	*Age 20-30s MC		*Age 20-30s most commonly
	*Turkey, Japan, Middle East		*More common in Turkey, Japan, Middle East
	*Triad: Recurrent oral aphthous ulcers, genital ulcers, and [[uveitis]]		*Triad: Recurrent oral aphthous ulcers, genital ulcers, and [[uveitis]]
	*Classically painful ulcer with necrotic center and red rim		*Classically painful ulcer with necrotic center and red rim
	*Skin: Subcutaneous nodules, pyoderma gangrenosum, cutaneous thrombophlebitis, pustular acne-like folliculitis		*Skin: Subcutaneous nodules, pyoderma gangrenosum, cutaneous thrombophlebitis, pustular acne-like folliculitis
	*Ocular: [[Uveitis]], iritis, optic neuritis, vision loss, hypopyon		*Ocular: [[Uveitis]], iritis, [[optic neuritis]], [[vision loss]], hypopyon
	*Neurologic: Brainstem and corticospinal tract syndromes, aseptic meningoencephalitis, increased ICP, [[cerebral sinus thrombosis]], optic nerve ischemia		*Neurologic: Brainstem and corticospinal tract syndromes, aseptic [[meningoencephalitis]], [[increased ICP]], [[cerebral sinus thrombosis]], optic nerve ischemia
	*GI: Ulcers, obstruction, ileocecal perforation		*GI: Ulcers, obstruction, ileocecal perforation
	*Inflammatory ~~oligoarthritis~~		*Inflammatory oligo[[arthritis]]
	*Vasculopathy: Aneurysm, vasculitis, superficial thrombophlebitis, thrombosis		*Vasculopathy: Aneurysm, [[vasculitis]], superficial [[thrombophlebitis]], thrombosis
	*Cardiac: Myocarditis, endocarditis, pericarditis		*Cardiac: [[Myocarditis]], [[endocarditis]], [[pericarditis]]
	*Renal: Glomerulonephritis, amyloidosis		*Renal: [[Glomerulonephritis]], amyloidosis
	*Pulmonary: Pleural effusions, pulmonary hypertension, pulmonary aneurysm		*Pulmonary: [[Pleural effusions]], [[pulmonary hypertension]], pulmonary aneurysm

	==Differential Diagnosis==		==Differential Diagnosis==
Line 29:		Line 29:
	*celiac disease		*celiac disease
	*[[SLE]]		*[[SLE]]
	*auto-inflammatory disorders
	*[[Sjogren's]]		*[[Sjogren's]]
	*[[MS]]		*[[MS]]
	*[[~~sarcoidosis~~]]		*[[Sarcoidosis]]
	*[[~~syphillis~~]]		*[[Syphilis]]
	*[[TB]]		*[[TB]]
	*malignancy		*malignancy
	*~~reactive~~ arthritis		*[[Reactive arthritis]]
	*[[HIV]]		*[[HIV]]
	*~~vasculitides~~		*Other [[vasculitis syndromes]]

	==Evaluation==		==Evaluation==
Line 54:		Line 53:
	==Management==		==Management==
	*Rheumatology consult +/- multidisciplinary consults		*Rheumatology consult +/- multidisciplinary consults
	*Oral and genital ulcers: Topical ~~steroid~~		*Oral and genital ulcers: [[Topical steroids]]
	*Severe mucocutaneous disease: [[Prednisone]] 1mg/kg, low-dose thalidomide, or methotrexate		*Severe mucocutaneous disease: [[Prednisone]] 1mg/kg, low-dose thalidomide, or methotrexate
	*Systemic disease: Steroid +/- cyclophosphamide or azathioprine		*Systemic disease: Steroid +/- [[cyclophosphamide]] or [[azathioprine]]
	*Ocular: Prednisone + azathioprine and rapid ophthalmologist referral		*Ocular: Prednisone + azathioprine and rapid ophthalmologist referral
	*Cerebral [[venous sinus thrombosis]]- ~~Heparinization~~		*Cerebral [[venous sinus thrombosis]]- [[heparin]]

	==References==		==References==

ClaireLewis at 22:28, 10 September 2016

2016-09-10T22:28:25Z

← Older revision		Revision as of 22:28, 10 September 2016
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	==Background==		==Background==
			[[File:Behcet's.png\|thumb\|]]
	*Chronic small-vessel vasculitis		*Chronic small-vessel vasculitis
	*Mucocutaneous, ocular, CV, renal, GI, pulmonary, urologic, musculoskeletal, CNS involvement		*Mucocutaneous, ocular, cardiovascular, renal, GI, pulmonary, urologic, musculoskeletal, CNS involvement
	*Aphthous oral ulcers + ≥ 2 of following: Genital aphthae, cutaneous lesions, and neurological, oral or rheumatologic manifestations		*Aphthous oral ulcers + ≥ 2 of following: Genital aphthae, cutaneous lesions, and neurological, oral or rheumatologic manifestations

Line 7:		Line 8:
	*Age 20-30s MC		*Age 20-30s MC
	*Turkey, Japan, Middle East		*Turkey, Japan, Middle East
	*Triad: Recurrent oral aphthous ulcers, genital ulcers, and uveitis		*Triad: Recurrent oral aphthous ulcers, genital ulcers, and [[uveitis]]
	*Classically painful ulcer with necrotic center and red rim		*Classically painful ulcer with necrotic center and red rim
	*Skin: Subcutaneous nodules, pyoderma gangrenosum, cutaneous thrombophlebitis, pustular acne-like folliculitis		*Skin: Subcutaneous nodules, pyoderma gangrenosum, cutaneous thrombophlebitis, pustular acne-like folliculitis
	*Ocular: Uveitis, iritis, optic neuritis, vision loss, hypopyon		*Ocular: [[Uveitis]], iritis, optic neuritis, vision loss, hypopyon
	*Neurologic: Brainstem and corticospinal tract syndromes, aseptic meningoencephalitis, increased ICP, cerebral sinus thrombosis, optic nerve ischemia		*Neurologic: Brainstem and corticospinal tract syndromes, aseptic meningoencephalitis, increased ICP, [[cerebral sinus thrombosis]], optic nerve ischemia
	*GI: Ulcers, obstruction, ileocecal perforation		*GI: Ulcers, obstruction, ileocecal perforation
	*Inflammatory oligoarthritis		*Inflammatory oligoarthritis

Rossdonaldson1: Text replacement - "HTN" to "hypertension"

2016-07-30T20:11:51Z

Text replacement - "HTN" to "hypertension"

← Older revision		Revision as of 20:11, 30 July 2016
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	*Cardiac: Myocarditis, endocarditis, pericarditis		*Cardiac: Myocarditis, endocarditis, pericarditis
	*Renal: Glomerulonephritis, amyloidosis		*Renal: Glomerulonephritis, amyloidosis
	*Pulmonary: Pleural effusions, pulmonary ~~HTN~~, pulmonary aneurysm		*Pulmonary: Pleural effusions, pulmonary hypertension, pulmonary aneurysm

	==Differential Diagnosis==		==Differential Diagnosis==

Neil.m.young: Text replacement - "==Diagnosis==" to "==Evaluation=="

2016-07-23T03:37:41Z

Text replacement - "==Diagnosis==" to "==Evaluation=="

← Older revision		Revision as of 03:37, 23 July 2016
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	*vasculitides		*vasculitides

	==~~Diagnosis~~==		==Evaluation==
	*Clinical diagnosis		*Clinical diagnosis
	*ESR/CRP elevated		*ESR/CRP elevated

ClaireLewis: /* Differential Diagnosis */

2016-07-13T07:50:57Z

Differential Diagnosis

← Older revision		Revision as of 07:50, 13 July 2016
Line 26:		Line 26:
	*IVD		*IVD
	*[[SJS]]		*[[SJS]]
	*celiac dz		*celiac disease
	*[[SLE]]		*[[SLE]]
	*auto-inflammatory disorders		*auto-inflammatory disorders

Neil.m.young: Text replacement - "* " to "*"

2016-07-04T17:56:26Z

Text replacement - "* " to "*"

← Older revision		Revision as of 17:56, 4 July 2016
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	==Background==		==Background==
	* Chronic small-vessel vasculitis		*Chronic small-vessel vasculitis
	* Mucocutaneous, ocular, CV, renal, GI, pulmonary, urologic, musculoskeletal, CNS involvement		*Mucocutaneous, ocular, CV, renal, GI, pulmonary, urologic, musculoskeletal, CNS involvement
	* Aphthous oral ulcers + ≥ 2 of following: Genital aphthae, cutaneous lesions, and neurological, oral or rheumatologic manifestations		*Aphthous oral ulcers + ≥ 2 of following: Genital aphthae, cutaneous lesions, and neurological, oral or rheumatologic manifestations

	==Clinical Features==		==Clinical Features==
	* Age 20-30s MC		*Age 20-30s MC
	* Turkey, Japan, Middle East		*Turkey, Japan, Middle East
	* Triad: Recurrent oral aphthous ulcers, genital ulcers, and uveitis		*Triad: Recurrent oral aphthous ulcers, genital ulcers, and uveitis
	* Classically painful ulcer with necrotic center and red rim		*Classically painful ulcer with necrotic center and red rim
	* Skin: Subcutaneous nodules, pyoderma gangrenosum, cutaneous thrombophlebitis, pustular acne-like folliculitis		*Skin: Subcutaneous nodules, pyoderma gangrenosum, cutaneous thrombophlebitis, pustular acne-like folliculitis
	* Ocular: Uveitis, iritis, optic neuritis, vision loss, hypopyon		*Ocular: Uveitis, iritis, optic neuritis, vision loss, hypopyon
	* Neurologic: Brainstem and corticospinal tract syndromes, aseptic meningoencephalitis, increased ICP, cerebral sinus thrombosis, optic nerve ischemia		*Neurologic: Brainstem and corticospinal tract syndromes, aseptic meningoencephalitis, increased ICP, cerebral sinus thrombosis, optic nerve ischemia
	* GI: Ulcers, obstruction, ileocecal perforation		*GI: Ulcers, obstruction, ileocecal perforation
	* Inflammatory oligoarthritis		*Inflammatory oligoarthritis
	* Vasculopathy: Aneurysm, vasculitis, superficial thrombophlebitis, thrombosis		*Vasculopathy: Aneurysm, vasculitis, superficial thrombophlebitis, thrombosis
	* Cardiac: Myocarditis, endocarditis, pericarditis		*Cardiac: Myocarditis, endocarditis, pericarditis
	* Renal: Glomerulonephritis, amyloidosis		*Renal: Glomerulonephritis, amyloidosis
	* Pulmonary: Pleural effusions, pulmonary HTN, pulmonary aneurysm		*Pulmonary: Pleural effusions, pulmonary HTN, pulmonary aneurysm

	==Differential Diagnosis==		==Differential Diagnosis==
	* [[HSV]]		*[[HSV]]
	*[[lichen planus]]		*[[lichen planus]]
	*[[pemphigus vulgaris]]		*[[pemphigus vulgaris]]
Line 40:		Line 40:

	==Diagnosis==		==Diagnosis==
	* Clinical diagnosis		*Clinical diagnosis
	* ESR/CRP elevated		*ESR/CRP elevated

	===Classification===		===Classification===
	* International Study Group Criteria		*International Study Group Criteria
	* Recurrent oral aphthae (at least 3 times in 1 year) + 2 of the following in absence of other systemic diseases:		*Recurrent oral aphthae (at least 3 times in 1 year) + 2 of the following in absence of other systemic diseases:
	** Recurrent genital aphthae		**Recurrent genital aphthae
	** Eye lesions		**Eye lesions
	** Skin lesions		**Skin lesions
	** A positive pathery test		**A positive pathery test

	==Management==		==Management==
	* Rheumatology consult +/- multidisciplinary consults		*Rheumatology consult +/- multidisciplinary consults
	* Oral and genital ulcers: Topical steroid		*Oral and genital ulcers: Topical steroid
	* Severe mucocutaneous disease: [[Prednisone]] 1mg/kg, low-dose thalidomide, or methotrexate		*Severe mucocutaneous disease: [[Prednisone]] 1mg/kg, low-dose thalidomide, or methotrexate
	* Systemic disease: Steroid +/- cyclophosphamide or azathioprine		*Systemic disease: Steroid +/- cyclophosphamide or azathioprine
	* Ocular: Prednisone + azathioprine and rapid ophthalmologist referral		*Ocular: Prednisone + azathioprine and rapid ophthalmologist referral
	* Cerebral [[venous sinus thrombosis]]- Heparinization		*Cerebral [[venous sinus thrombosis]]- Heparinization

	==References==		==References==
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	*Rosen's Emergency Medicine 8th edition. 2013. Chapter: Erythematosus and the Vasculitides. p1540.		*Rosen's Emergency Medicine 8th edition. 2013. Chapter: Erythematosus and the Vasculitides. p1540.
	*Smith EL, et al. Clinical manifestations and diagnosis of Behcet's disease. In: Post T, ed. UpToDate. Waltham, Mass.: UpToDate; 2014. www.uptodate.com. Accessed December 22, 2014.		*Smith EL, et al. Clinical manifestations and diagnosis of Behcet's disease. In: Post T, ed. UpToDate. Waltham, Mass.: UpToDate; 2014. www.uptodate.com. Accessed December 22, 2014.
	* Alnaimat FA, et al. (2014, Dec 16). Behcet Disease. eMedicine. Retrieved 12/22/2014 from http://emedicine.medscape.com/article/329099-overview		*Alnaimat FA, et al. (2014, Dec 16). Behcet Disease. eMedicine. Retrieved 12/22/2014 from http://emedicine.medscape.com/article/329099-overview

	[[Category:Rheumatology]]		[[Category:Rheumatology]]

Ostermayer: Text replacement - "Category:Rheum" to "Category:Rheumatology"

2016-03-22T16:17:11Z

Text replacement - "Category:Rheum" to "Category:Rheumatology"

← Older revision		Revision as of 16:17, 22 March 2016
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	* Alnaimat FA, et al. (2014, Dec 16). Behcet Disease. eMedicine. Retrieved 12/22/2014 from http://emedicine.medscape.com/article/329099-overview		* Alnaimat FA, et al. (2014, Dec 16). Behcet Disease. eMedicine. Retrieved 12/22/2014 from http://emedicine.medscape.com/article/329099-overview

	[[Category:~~Rheum~~]]		[[Category:Rheumatology]]

Kxl328 at 00:45, 12 December 2015

2015-12-12T00:45:19Z

← Older revision		Revision as of 00:45, 12 December 2015
Line 8:		Line 8:
	* Turkey, Japan, Middle East		* Turkey, Japan, Middle East
	* Triad: Recurrent oral aphthous ulcers, genital ulcers, and uveitis		* Triad: Recurrent oral aphthous ulcers, genital ulcers, and uveitis
			* Classically painful ulcer with necrotic center and red rim
	* Skin: Subcutaneous nodules, pyoderma gangrenosum, cutaneous thrombophlebitis, pustular acne-like folliculitis		* Skin: Subcutaneous nodules, pyoderma gangrenosum, cutaneous thrombophlebitis, pustular acne-like folliculitis
	* Ocular: Uveitis, iritis, optic neuritis, vision loss, hypopyon		* Ocular: Uveitis, iritis, optic neuritis, vision loss, hypopyon

Rossdonaldson1 at 13:46, 20 July 2015

2015-07-20T13:46:27Z

← Older revision		Revision as of 13:46, 20 July 2015
Line 4:		Line 4:
	* Aphthous oral ulcers + ≥ 2 of following: Genital aphthae, cutaneous lesions, and neurological, oral or rheumatologic manifestations		* Aphthous oral ulcers + ≥ 2 of following: Genital aphthae, cutaneous lesions, and neurological, oral or rheumatologic manifestations

	~~==Diagnosis==~~		==Clinical Features==
	===Clinical Features===
	* Age 20-30s MC		* Age 20-30s MC
	* Turkey, Japan, Middle East		* Turkey, Japan, Middle East