Ostermayer: Created page with "==General== Type: Is Generation::1st generation Is DrugClass::Cephalosporin Dosage Forms: powder for injection Dosage Strengths: 250mg, 500mg, 1g Routes of Administration: IV, IM Common Trade Names: Ceporin, Loridine ==Adult Dosing== ===General=== Mild-Moderate: 250-500mg IM/IV q6h Severe: 1g IM/IV q6h Max: 4g/day (Strict limit due to nephrotoxicity risk) ===UTI, Uncomplicated=== 500mg IM/IV q6h ===Endocarditis Prophylaxis=== 1g IM/IV x1 (30-..."

2026-01-27T17:24:44Z

Created page with "==General== *Type: Is Generation::1st generation Is DrugClass::Cephalosporin *Dosage Forms: powder for injection *Dosage Strengths: 250mg, 500mg, 1g *Routes of Administration: IV, IM *Common Trade Names: Ceporin, Loridine ==Adult Dosing== ===General=== *Mild-Moderate: 250-500mg IM/IV q6h *Severe: 1g IM/IV q6h *Max: 4g/day (Strict limit due to nephrotoxicity risk) ===UTI, Uncomplicated=== *500mg IM/IV q6h ===Endocarditis Prophylaxis=== *1g IM/IV x1 (30-..."

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==General==
*Type: [[Is Generation::1st generation]] [[Is DrugClass::Cephalosporin]]
*Dosage Forms: powder for injection
*Dosage Strengths: 250mg, 500mg, 1g
*Routes of Administration: IV, IM
*Common Trade Names: Ceporin, Loridine

==Adult Dosing==
===General===
*Mild-Moderate: 250-500mg IM/IV q6h
*Severe: 1g IM/IV q6h
*Max: 4g/day (Strict limit due to nephrotoxicity risk)

===[[UTI]], Uncomplicated===
*500mg IM/IV q6h

===[[Endocarditis]] Prophylaxis===
*1g IM/IV x1 (30-60 min before procedure)

==Pediatric Dosing==
===General===
*30-50 mg/kg/day IM/IV divided q6-8h
*Max: 4g/day

==Special Populations==
*Pregnancy: B
*Lactation: Excreted in breast milk; use caution
*Renal
**Adult
***CrCl 30-50: Max 3g/day
***CrCl 10-29: Max 2g/day
***CrCl <10: Max 1g/day
***Note: Highly nephrotoxic; avoid in pre-existing renal impairment if possible.
**Pediatric
***Not well defined; avoid use.
*Hepatic
**No adjustment usually required

==Contraindications==
*Allergy to class/drug
*Pre-existing significant renal impairment (Relative)

==Adverse Reactions==
===Serious===
*'''Nephrotoxicity''' (Dose-dependent proximal tubular necrosis)
*[[Anaphylaxis]]
*[[Neutropenia]]
*[[Leukopenia]]
*[[Seizures]] (accumulation in renal failure)
*[[Clostridium difficile]]

===Common===
*[[Rash]]
*[[Urticaria]]
*[[Nausea and Vomiting]]
*Injection site pain/phlebitis
*Pruritus
*Eosinophilia

==Pharmacology==
*Half-life: 1.1-1.5h
*Metabolism: Not significantly metabolized
*Excretion: Urine (glomerular filtration)
*Mechanism of Action: Bactericidal; inhibits cell wall mucopeptide synthesis

==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy</ref>==
{| class="wikitable"
| align="center" style="background:#f0f0f0;"|'''Group'''
| align="center" style="background:#f0f0f0;"|'''Organism'''
| align="center" style="background:#f0f0f0;"|'''Sensitivity'''
|-
| Gram Positive||[[Strep. Group A, B, C, G]]||'''S'''
|-
| ||[[Strep. Pneumoniae]]||'''S'''
|-
| ||[[Viridans strep]]||'''S'''
|-
| ||Strep. anginosus gp||X1
|-
| ||[[Enterococcus faecalis]]||R
|-
| ||[[Enterococcus faecium]]||R
|-
| ||[[MSSA]]||'''S'''
|-
| ||[[MRSA]]||R
|-
| ||[[CA-MRSA]]||R
|-
| ||[[Staph. Epidermidis]]||I
|-
| ||[[C. jeikeium]]||R
|-
| ||[[L. monocytogenes]]||R
|-
| Gram Negatives||[[N. gonorrhoeae]]||'''S'''
|-
| ||[[N. meningitidis]]||R
|-
| ||[[Moraxella catarrhalis]]||I
|-
| ||[[H. influenzae]]||I
|-
| ||[[E. coli]]||'''S'''
|-
| ||[[Klebsiella]] sp||'''S'''
|-
| ||E. coli/Klebsiella ESBL+||R
|-
| ||E coli/Klebsiella KPC+||R
|-
| ||[[Enterobacter]] sp, AmpC neg||R
|-
| ||[[Enterobacter]] sp, AmpC pos||R
|-
| ||[[Serratia]] sp||R
|-
| ||Serratia marcescens||R
|-
| ||[[Salmonella]] sp||X1
|-
| ||[[Shigella]] sp||X1
|-
| ||[[Proteus mirabilis]]||'''S'''
|-
| ||[[Proteus vulgaris]]||R
|-
| ||[[Providencia sp.]]||R
|-
| ||[[Morganella sp.]]||R
|-
| ||[[Citrobacter freundii]]||R
|-
| ||[[Citrobacter diversus]]||R
|-
| ||[[Citrobacter sp.]]||R
|-
| ||[[Aeromonas sp]]||R
|-
| ||[[Acinetobacter sp.]]||R
|-
| ||[[Pseudomonas aeruginosa]]||R
|-
| ||[[Burkholderia cepacia]]||R
|-
| ||[[Stenotrophomonas maltophilia]]||R
|-
| ||[[Yersinia enterocolitica]]||R
|-
| ||[[Francisella tularensis]]||X1
|-
| ||[[Brucella sp.]]||X1
|-
| ||[[Legionella sp.]]||R
|-
| ||[[Pasteurella multocida]]||X1
|-
| ||[[Haemophilus ducreyi]]||X1
|-
| ||[[Vibrio vulnificus]]||X1
|-
| Misc||[[Chlamydophila sp]]||X1
|-
| ||[[Mycoplasm pneumoniae]]||X1
|-
| ||[[Rickettsia sp]]||X1
|-
| ||[[Mycobacterium avium]]||R
|-
| Anaerobes||[[Actinomyces]]||X1
|-
| ||[[Bacteroides fragilis]]||R
|-
| ||[[Prevotella melaninogenica]]||X1
|-
| ||[[Clostridium difficile]]||X1
|-
| ||[[Clostridium (not difficile)]]||X1
|-
| ||[[Fusobacterium necrophorum]]||X1
|-
| ||[[Peptostreptococcus sp.]]||X1
|}

===Key===
{{Template:Antibacterial Spectra Key}}

==See Also==
*[[Antibiotics (Main)]]

==References==
<references/>

[[Category:Pharmacology]] [[Category:ID]]

Cefaloridine - Revision history