Ostermayer: Created page with "==General== Type: Is Generation::3rd generation Is DrugClass::Cephalosporin Dosage Forms: powder for injection Dosage Strengths: 0.5g, 1g Routes of Administration: IV, IM Common Trade Names: Cefmax, Bestcall ==Adult Dosing== ===General=== Standard: 500mg-1g IM/IV q12h Severe: 2-4g/day IM/IV divided q6-8h Max: 4g/day ===Pneumonia / Respiratory Tract Infections=== 1-2g IM/IV divided q12h ===UTI, Complicated and Uncomplicated=== 0.5-1g IM/IV q12..."

2026-01-28T19:36:52Z

Created page with "==General== *Type: Is Generation::3rd generation Is DrugClass::Cephalosporin *Dosage Forms: powder for injection *Dosage Strengths: 0.5g, 1g *Routes of Administration: IV, IM *Common Trade Names: Cefmax, Bestcall ==Adult Dosing== ===General=== *Standard: 500mg-1g IM/IV q12h *Severe: 2-4g/day IM/IV divided q6-8h *Max: 4g/day ===Pneumonia / Respiratory Tract Infections=== *1-2g IM/IV divided q12h ===UTI, Complicated and Uncomplicated=== *0.5-1g IM/IV q12..."

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==General==
*Type: [[Is Generation::3rd generation]] [[Is DrugClass::Cephalosporin]]
*Dosage Forms: powder for injection
*Dosage Strengths: 0.5g, 1g
*Routes of Administration: IV, IM
*Common Trade Names: Cefmax, Bestcall

==Adult Dosing==
===General===
*Standard: 500mg-1g IM/IV q12h
*Severe: 2-4g/day IM/IV divided q6-8h
*Max: 4g/day

===[[Pneumonia]] / Respiratory Tract Infections===
*1-2g IM/IV divided q12h

===[[UTI]], Complicated and Uncomplicated===
*0.5-1g IM/IV q12h

===Intra-abdominal / Gynecological Infections===
*1g IM/IV q8h
*Provides better anaerobic coverage than many other cephalosporins (similar to cefoxitin/cefotetan)

===[[Gonorrhea]]===
*1g IM x 1

==Pediatric Dosing==
===General===
*40-100mg/kg/day IM/IV divided q6-12h
*Severe infections: Up to 200mg/kg/day divided q6h
*Max: 4g/day

===[[Meningitis]]===
*200mg/kg/day IM/IV divided q6h

==Special Populations==
*Pregnancy: B
*Lactation: Excreted in breast milk; withdraw drug or stop nursing
*Renal
**Adult
***CrCl 10-30: 500mg-1g q24h
***CrCl <10: 500mg-1g q48h
***Hemodialysis: Administer dose after dialysis
**Pediatric
***Renal impairment requires adjustment; defined data limited, generally widen interval based on GFR.
*Hepatic
**No specific adjustment defined

==Contraindications==
*Allergy to class/drug (Cephalosporins)
*History of anaphylactic shock

==Adverse Reactions==
===Serious===
*[[Anaphylaxis]]
*[[Stevens-Johnson Syndrome]]
*[[Clostridium difficile]]
*Hypoprothrombinemia (Bleeding tendency)
**Contains N-methylthiotetrazole (MTT) side chain which inhibits Vitamin K reduction.
*Disulfiram-like reaction (with alcohol intake)

===Common===
*[[Diarrhea]]
*[[Rash]]
*[[Nausea]]
*Injection site pain/phlebitis
*Eosinophilia
*Transaminitis

==Pharmacology==
*Half-life: ~1 hour (prolonged in renal failure)
*Metabolism: Minimal; N-methylthiotetrazole (MTT) side chain is dissociated.
*Excretion: Urine
*Mechanism of Action: Bactericidal; inhibits cell wall mucopeptide synthesis.
*Chemical Note: Possesses MTT side chain (associated with bleeding risk and alcohol intolerance).

==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy</ref>==
{| class="wikitable"
| align="center" style="background:#f0f0f0;"|'''Group'''
| align="center" style="background:#f0f0f0;"|'''Organism'''
| align="center" style="background:#f0f0f0;"|'''Sensitivity'''
|-
| Gram Positive||[[Strep. Group A, B, C, G]]||'''S'''
|-
| ||[[Strep. Pneumoniae]]||'''S'''
|-
| ||[[Viridans strep]]||'''S'''
|-
| ||Strep. anginosus gp||X1
|-
| ||[[Enterococcus faecalis]]||R
|-
| ||[[Enterococcus faecium]]||R
|-
| ||[[MSSA]]||'''S'''
|-
| ||[[MRSA]]||R
|-
| ||[[CA-MRSA]]||R
|-
| ||[[Staph. Epidermidis]]||I
|-
| ||[[C. jeikeium]]||R
|-
| ||[[L. monocytogenes]]||R
|-
| Gram Negatives||[[N. gonorrhoeae]]||'''S'''
|-
| ||[[N. meningitidis]]||'''S'''
|-
| ||[[Moraxella catarrhalis]]||'''S'''
|-
| ||[[H. influenzae]]||'''S'''
|-
| ||[[E. coli]]||'''S'''
|-
| ||[[Klebsiella]] sp||'''S'''
|-
| ||E. coli/Klebsiella ESBL+||R
|-
| ||E coli/Klebsiella KPC+||R
|-
| ||[[Enterobacter]] sp, AmpC neg||I
|-
| ||[[Enterobacter]] sp, AmpC pos||R
|-
| ||[[Serratia]] sp||'''S'''
|-
| ||Serratia marcescens||'''S'''
|-
| ||[[Salmonella]] sp||'''S'''
|-
| ||[[Shigella]] sp||'''S'''
|-
| ||[[Proteus mirabilis]]||'''S'''
|-
| ||[[Proteus vulgaris]]||'''S'''
|-
| ||[[Providencia sp.]]||'''S'''
|-
| ||[[Morganella sp.]]||'''S'''
|-
| ||[[Citrobacter freundii]]||I
|-
| ||[[Citrobacter diversus]]||'''S'''
|-
| ||[[Citrobacter sp.]]||I
|-
| ||[[Aeromonas sp]]||'''S'''
|-
| ||[[Acinetobacter sp.]]||R
|-
| ||[[Pseudomonas aeruginosa]]||R
|-
| ||[[Burkholderia cepacia]]||R
|-
| ||[[Stenotrophomonas maltophilia]]||R
|-
| ||[[Yersinia enterocolitica]]||'''S'''
|-
| ||[[Francisella tularensis]]||X1
|-
| ||[[Brucella sp.]]||X1
|-
| ||[[Legionella sp.]]||R
|-
| ||[[Pasteurella multocida]]||'''S'''
|-
| ||[[Haemophilus ducreyi]]||'''S'''
|-
| ||[[Vibrio vulnificus]]||'''S'''
|-
| Misc||[[Chlamydophila sp]]||R
|-
| ||[[Mycoplasm pneumoniae]]||R
|-
| ||[[Rickettsia sp]]||R
|-
| ||[[Mycobacterium avium]]||R
|-
| Anaerobes||[[Actinomyces]]||'''S'''
|-
| ||[[Bacteroides fragilis]]||I
|-
| ||[[Prevotella melaninogenica]]||'''S'''
|-
| ||[[Clostridium difficile]]||X1
|-
| ||[[Clostridium (not difficile)]]||'''S'''
|-
| ||[[Fusobacterium necrophorum]]||'''S'''
|-
| ||[[Peptostreptococcus sp.]]||'''S'''
|}

===Key===
{{Template:Antibacterial Spectra Key}}

==See Also==
*[[Antibiotics (Main)]]

==References==
<references/>

[[Category:Pharmacology]] [[Category:ID]]

Cefmenoxime - Revision history