Ostermayer: Created page with "==General== Type: Is Generation::2nd generation Is DrugClass::Cephalosporin Dosage Forms: powder for injection Dosage Strengths: 500mg; 1g, 10g Routes of Administration: IV, IM Common Trade Names: Precef ==Adult Dosing== ===General=== 0.5-1g IM/IV q12h Max: 4g/day ===UTI, Uncomplicated=== 0.5-1g IM/IV q12h ===Community Acquired Pneumonia=== 0.5-1g IM/IV q12h ===Surgical Prophylaxis=== 0.5-1g IM/IV 1 hour prior to surgery *Intraoperative: May..."

2026-01-27T17:48:55Z

Created page with "==General== *Type: Is Generation::2nd generation Is DrugClass::Cephalosporin *Dosage Forms: powder for injection *Dosage Strengths: 500mg; 1g, 10g *Routes of Administration: IV, IM *Common Trade Names: Precef ==Adult Dosing== ===General=== *0.5-1g IM/IV q12h *Max: 4g/day ===UTI, Uncomplicated=== *0.5-1g IM/IV q12h ===Community Acquired Pneumonia=== *0.5-1g IM/IV q12h ===Surgical Prophylaxis=== *0.5-1g IM/IV 1 hour prior to surgery *Intraoperative: May..."

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==General==
*Type: [[Is Generation::2nd generation]] [[Is DrugClass::Cephalosporin]]
*Dosage Forms: powder for injection
*Dosage Strengths: 500mg; 1g, 10g
*Routes of Administration: IV, IM
*Common Trade Names: Precef

==Adult Dosing==
===General===
*0.5-1g IM/IV q12h
*Max: 4g/day

===[[UTI]], Uncomplicated===
*0.5-1g IM/IV q12h

===Community Acquired [[Pneumonia]]===
*0.5-1g IM/IV q12h

===Surgical Prophylaxis===
*0.5-1g IM/IV 1 hour prior to surgery
*Intraoperative: May repeat during lengthy procedures (>2hr)
*Postoperative: 0.5-1g IM/IV q12h for 24h

==Pediatric Dosing==
===General (>1 Year)===
*20-40mg/kg/day IM/IV divided q12h
*Max: 4g/day

==Special Populations==
*Pregnancy: B
*Lactation: Excreted in breast milk; use caution
*Renal
**Adult
***CrCl >60: Standard dosing (q12h)
***CrCl 20-60: Give standard dose q24h
***CrCl <20: Give standard dose q48h
***Hemodialysis: Give supplement after dialysis
*Hepatic
**No adjustment defined

==Contraindications==
*Allergy to class/drug (Cephalosporins)
*Caution in Penicillin allergy (cross-reactivity)

==Adverse Reactions==
===Serious===
*[[Anaphylaxis]]
*[[Stevens-Johnson Syndrome]]
*[[Clostridium difficile]]
*Hemolytic Anemia
*Neutropenia
*[[Thrombocytopenia]]

===Common===
*Injection site pain (IM) or phlebitis (IV)
*[[Diarrhea]]
*[[Rash]]
*[[Nausea and Vomiting]]
*Transient transaminitis
*Eosinophilia

==Pharmacology==
*Half-life: 2.9 - 3.0h
*Metabolism: Not metabolized
*Excretion: Urine (unchanged)
*Mechanism of Action: Bactericidal; inhibits cell wall mucopeptide synthesis

==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy</ref>==
{| class="wikitable"
| align="center" style="background:#f0f0f0;"|'''Group'''
| align="center" style="background:#f0f0f0;"|'''Organism'''
| align="center" style="background:#f0f0f0;"|'''Sensitivity'''
|-
| Gram Positive||[[Strep. Group A, B, C, G]]||'''S'''
|-
| ||[[Strep. Pneumoniae]]||'''S'''
|-
| ||[[Viridans strep]]||'''S'''
|-
| ||Strep. anginosus gp||X1
|-
| ||[[Enterococcus faecalis]]||R
|-
| ||[[Enterococcus faecium]]||R
|-
| ||[[MSSA]]||'''S'''
|-
| ||[[MRSA]]||R
|-
| ||[[CA-MRSA]]||R
|-
| ||[[Staph. Epidermidis]]||I
|-
| ||[[C. jeikeium]]||R
|-
| ||[[L. monocytogenes]]||R
|-
| Gram Negatives||[[N. gonorrhoeae]]||'''S'''
|-
| ||[[N. meningitidis]]||'''S'''
|-
| ||[[Moraxella catarrhalis]]||'''S'''
|-
| ||[[H. influenzae]]||'''S'''
|-
| ||[[E. coli]]||'''S'''
|-
| ||[[Klebsiella]] sp||'''S'''
|-
| ||E. coli/Klebsiella ESBL+||R
|-
| ||E coli/Klebsiella KPC+||R
|-
| ||[[Enterobacter]] sp, AmpC neg||I
|-
| ||[[Enterobacter]] sp, AmpC pos||R
|-
| ||[[Serratia]] sp||R
|-
| ||Serratia marcescens||R
|-
| ||[[Salmonella]] sp||'''S'''
|-
| ||[[Shigella]] sp||'''S'''
|-
| ||[[Proteus mirabilis]]||'''S'''
|-
| ||[[Proteus vulgaris]]||I
|-
| ||[[Providencia sp.]]||R
|-
| ||[[Morganella sp.]]||R
|-
| ||[[Citrobacter freundii]]||R
|-
| ||[[Citrobacter diversus]]||I
|-
| ||[[Citrobacter sp.]]||I
|-
| ||[[Aeromonas sp]]||X1
|-
| ||[[Acinetobacter sp.]]||R
|-
| ||[[Pseudomonas aeruginosa]]||R
|-
| ||[[Burkholderia cepacia]]||R
|-
| ||[[Stenotrophomonas maltophilia]]||R
|-
| ||[[Yersinia enterocolitica]]||X1
|-
| ||[[Francisella tularensis]]||X1
|-
| ||[[Brucella sp.]]||X1
|-
| ||[[Legionella sp.]]||R
|-
| ||[[Pasteurella multocida]]||'''S'''
|-
| ||[[Haemophilus ducreyi]]||X1
|-
| ||[[Vibrio vulnificus]]||X1
|-
| Misc||[[Chlamydophila sp]]||R
|-
| ||[[Mycoplasm pneumoniae]]||R
|-
| ||[[Rickettsia sp]]||R
|-
| ||[[Mycobacterium avium]]||R
|-
| Anaerobes||[[Actinomyces]]||'''S'''
|-
| ||[[Bacteroides fragilis]]||R
|-
| ||[[Prevotella melaninogenica]]||I
|-
| ||[[Clostridium difficile]]||X1
|-
| ||[[Clostridium (not difficile)]]||'''S'''
|-
| ||[[Fusobacterium necrophorum]]||'''S'''
|-
| ||[[Peptostreptococcus sp.]]||'''S'''
|}

===Key===
{{Template:Antibacterial Spectra Key}}

==See Also==
*[[Antibiotics (Main)]]

==References==
<references/>

[[Category:Pharmacology]] [[Category:ID]]

Ceforanide - Revision history