https://wikem.org/w/index.php?action=history&feed=atom&title=Cefotiam 2026-04-17T15:10:01Z Revision history for this page on the wiki MediaWiki 1.38.2 https://wikem.org/w/index.php?title=Cefotiam&diff=385437&oldid=prev 2026-01-27T17:52:35Z

<p>Created page with &quot;==General== *Type: <a href="/w/index.php?title=Is_Generation::2nd_generation&amp;action=edit&amp;redlink=1" class="new" title="Is Generation::2nd generation (page does not exist)">Is Generation::2nd generation</a> <a href="/w/index.php?title=Is_DrugClass::Cephalosporin&amp;action=edit&amp;redlink=1" class="new" title="Is DrugClass::Cephalosporin (page does not exist)">Is DrugClass::Cephalosporin</a> *Dosage Forms: Powder for injection, tablet (as cefotiam hexetil) *Dosage Strengths: 250mg, 500mg, 1g, 2g *Routes of Administration: IV, IM, PO *Common Trade Names: Pansporin, Halospor ==Adult Dosing== ===General (Parenteral)=== *Susceptible infections: 0.5-2g IV/IM divided q6-12h depending on severity *Max: 6g/day *Sepsis/Severe infections: Up to 4g/day divided q6-8h ===General (Oral)...&quot;</p> <p><b>New page</b></p><div>==General==<br /> *Type: [[Is Generation::2nd generation]] [[Is DrugClass::Cephalosporin]]<br /> *Dosage Forms: Powder for injection, tablet (as cefotiam hexetil)<br /> *Dosage Strengths: 250mg, 500mg, 1g, 2g<br /> *Routes of Administration: IV, IM, PO<br /> *Common Trade Names: Pansporin, Halospor<br /> <br /> ==Adult Dosing==<br /> ===General (Parenteral)===<br /> *Susceptible infections: 0.5-2g IV/IM divided q6-12h depending on severity<br /> *Max: 6g/day<br /> *Sepsis/Severe infections: Up to 4g/day divided q6-8h<br /> <br /> ===General (Oral)===<br /> *200-400mg PO bid<br /> <br /> ===Surgical Prophylaxis===<br /> *1g IV single dose (30-60 min before procedure)<br /> *May repeat post-operatively if procedure is prolonged<br /> <br /> ==Pediatric Dosing==<br /> ===General===<br /> *40-80 mg/kg/day IV/IM divided q6-8h<br /> *Severe infections: Up to 160 mg/kg/day divided q6-8h<br /> *Max: Adult dosing limits<br /> <br /> ==Special Populations==<br /> *Pregnancy: Category B<br /> *Lactation: Excreted in breast milk; use with caution<br /> *Renal<br /> **Dose reduction required for renal impairment<br /> **Adult<br /> ***CrCl &gt;30: Standard dosing<br /> ***CrCl 10-30: Reduce does by 50% or extend interval (q12-24h)<br /> ***CrCl &lt;10: Reduce dose by 50-75% and give q24h<br /> ***Hemodialysis: Supplement required after dialysis<br /> *Hepatic<br /> **No specific adjustment defined<br /> <br /> ==Contraindications==<br /> *Allergy to class/drug (Cephalosporins)<br /> *History of anaphylactic reaction to Penicillins<br /> <br /> ==Adverse Reactions==<br /> ===Serious===<br /> *[[Anaphylaxis]]<br /> *[[Stevens-Johnson Syndrome]]<br /> *[[Toxic Epidermal Necrolysis]]<br /> *Pseudomembranous colitis ([[Clostridium difficile]])<br /> *Nephrotoxicity<br /> *Bleeding disorders (hypoprothrombinemia)<br /> *Seizures (high doses in renal failure)<br /> <br /> ===Common===<br /> *[[Diarrhea]]<br /> *[[Nausea and Vomiting]]<br /> *[[Rash]]<br /> *Injection site pain/phlebitis<br /> *Elevated LFTs<br /> *Eosinophilia<br /> <br /> ==Pharmacology==<br /> *Half-life: 0.6 - 1.0 hours (prolonged in renal failure)<br /> *Metabolism: Not significantly metabolized (excreted unchanged)<br /> *Excretion: Urine (primary)<br /> *Mechanism of Action: Bactericidal; inhibits cell wall synthesis (final cross-linking of peptidoglycan)<br /> *Drug Interactions: <br /> **Disulfiram-like reaction with alcohol<br /> **Probenecid reduces renal clearance<br /> <br /> ==[[Antibiotic Sensitivities]]&lt;ref&gt;[https://mims.com/malaysia/drug/info/cefotiam?mtype=generic MIMS Cefotiam]&lt;/ref&gt;==<br /> {| class=&quot;wikitable&quot;<br /> | align=&quot;center&quot; style=&quot;background:#f0f0f0;&quot;|'''Group'''<br /> | align=&quot;center&quot; style=&quot;background:#f0f0f0;&quot;|'''Organism'''<br /> | align=&quot;center&quot; style=&quot;background:#f0f0f0;&quot;|'''Sensitivity'''<br /> |-<br /> | Gram Positive||[[Strep. Group A, B, C, G]]||'''S'''<br /> |-<br /> | ||[[Strep. Pneumoniae]]||'''S'''<br /> |-<br /> | ||[[Viridans strep]]||'''S'''<br /> |-<br /> | ||Strep. anginosus gp||X1<br /> |-<br /> | ||[[Enterococcus faecalis]]||R<br /> |-<br /> | ||[[Enterococcus faecium]]||R<br /> |-<br /> | ||[[MSSA]]||'''S'''<br /> |-<br /> | ||[[MRSA]]||R<br /> |-<br /> | ||[[CA-MRSA]]||R<br /> |-<br /> | ||[[Staph. Epidermidis]]||I<br /> |-<br /> | ||[[C. jeikeium]]||R<br /> |-<br /> | ||[[L. monocytogenes]]||R<br /> |-<br /> | Gram Negatives||[[N. gonorrhoeae]]||'''S'''<br /> |-<br /> | ||[[N. meningitidis]]||'''S'''<br /> |-<br /> | ||[[Moraxella catarrhalis]]||'''S'''<br /> |-<br /> | ||[[H. influenzae]]||'''S'''<br /> |-<br /> | ||[[E. coli]]||'''S'''<br /> |-<br /> | ||[[Klebsiella]] sp||'''S'''<br /> |-<br /> | ||E. coli/Klebsiella ESBL+||R<br /> |-<br /> | ||E coli/Klebsiella KPC+||R<br /> |-<br /> | ||[[Enterobacter]] sp, AmpC neg||I<br /> |-<br /> | ||[[Enterobacter]] sp, AmpC pos||R<br /> |-<br /> | ||[[Serratia]] sp||R<br /> |-<br /> | ||Serratia marcescens||R<br /> |-<br /> | ||[[Salmonella]] sp||'''S'''<br /> |-<br /> | ||[[Shigella]] sp||'''S'''<br /> |-<br /> | ||[[Proteus mirabilis]]||'''S'''<br /> |-<br /> | ||[[Proteus vulgaris]]||I<br /> |-<br /> | ||[[Providencia sp.]]||I<br /> |-<br /> | ||[[Morganella sp.]]||I<br /> |-<br /> | ||[[Citrobacter freundii]]||R<br /> |-<br /> | ||[[Citrobacter diversus]]||I<br /> |-<br /> | ||[[Citrobacter sp.]]||I<br /> |-<br /> | ||[[Aeromonas sp]]||X1<br /> |-<br /> | ||[[Acinetobacter sp.]]||R<br /> |-<br /> | ||[[Pseudomonas aeruginosa]]||R<br /> |-<br /> | ||[[Burkholderia cepacia]]||R<br /> |-<br /> | ||[[Stenotrophomonas maltophilia]]||R<br /> |-<br /> | ||[[Yersinia enterocolitica]]||X1<br /> |-<br /> | ||[[Francisella tularensis]]||X1<br /> |-<br /> | ||[[Brucella sp.]]||X1<br /> |-<br /> | ||[[Legionella sp.]]||R<br /> |-<br /> | ||[[Pasteurella multocida]]||'''S'''<br /> |-<br /> | ||[[Haemophilus ducreyi]]||X1<br /> |-<br /> | ||[[Vibrio vuln▍</div>

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