Ceftolozane/tazobactam - Revision history

Danbot: Add References

2026-03-22T09:38:24Z

Add References

← Older revision		Revision as of 09:38, 22 March 2026
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	*Ceftolozane: cephalosporin- binds to bacterial PCN-binding proteins, thus inhibiting bacterial cell wall synthesis		*Ceftolozane: cephalosporin- binds to bacterial PCN-binding proteins, thus inhibiting bacterial cell wall synthesis
	*Tazobactam: irreversibly inhibits some penicillinases and cephalosporinases and binds to some chromosomal and plasmid-mediated bacterial beta-lactamases		*Tazobactam: irreversibly inhibits some penicillinases and cephalosporinases and binds to some chromosomal and plasmid-mediated bacterial beta-lactamases

			==References==
			<references/>

	[[Category:ID]]		[[Category:ID]]

ClaireLewis at 18:17, 12 July 2017

2017-07-12T18:17:29Z

← Older revision		Revision as of 18:17, 12 July 2017
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	==General==		==General==
	*Type: Antibiotic (cephalosporin/beta-lactamase inhibitor combination)		*Type: [[Antibiotic]] (cephalosporin/beta-lactamase inhibitor combination)
	*Dosage Forms: IV		*Dosage Forms: IV
	*Common Trade Names: Zerbaxa		*Common Trade Names: Zerbaxa
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	==Pediatric Dosing==		==Pediatric Dosing==
	N/A		''Safety/efficacy not established in children''

	==Special Populations==		==Special Populations==
	*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: B		*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: B
	*Lactation:		*Lactation: Infant risk cannot be ruled out
	*Renal Dosing		*Renal Dosing: 750mg IV q8hr for moderate renal impairment, 375mg IV q8hr for severe impairment
	**Adult - 750mg IV q8hr for moderate renal impairment, 375mg IV q8hr for severe impairment		*Hepatic Dosing: no adjustment
	**Pediatric - N/A
	*Hepatic Dosing
	**Adult - N/A
	**Pediatric - N/A

	==Contraindications==		==Contraindications==
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	==Adverse Reactions==		==Adverse Reactions==
	===Serious===		===Serious===
			*C. difficile diarrhea
			*Renal impairment
			*Hypersensitivity
	===Common===		===Common===
			*Nausea, diarrhea
			*Headache
			*Fever

	==Pharmacology==		==Pharmacology==
	*Half-life:		*Half-life: Ceftolozane- ~3h, Tazobactam- ~1h
	*Metabolism: N/A		*Metabolism: N/A
	*Excretion: Renal (100%)		*Excretion: Renal (100%)
	*Mechanism of Action:
			==Mechanism of Action==
			*Ceftolozane: cephalosporin- binds to bacterial PCN-binding proteins, thus inhibiting bacterial cell wall synthesis
			*Tazobactam: irreversibly inhibits some penicillinases and cephalosporinases and binds to some chromosomal and plasmid-mediated bacterial beta-lactamases

	[[Category:ID]]		[[Category:ID]]

Mholtz at 06:01, 28 June 2017

2017-06-28T06:01:32Z

← Older revision		Revision as of 06:01, 28 June 2017
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	==General==		==General==
	*Type:		*Type: Antibiotic (cephalosporin/beta-lactamase inhibitor combination)
	*Dosage Forms:		*Dosage Forms: IV
	*Common Trade Names:		*Common Trade Names: Zerbaxa

	==Adult Dosing==		==Adult Dosing==
			*1.5 grams (1gm ceftolozane/0.5gm tazobactam) IV q8H

	==Pediatric Dosing==		==Pediatric Dosing==
			N/A

	==Special Populations==		==Special Populations==
	*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]:		*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: B
	*Lactation:		*Lactation:
	*Renal Dosing		*Renal Dosing
	**Adult		**Adult - 750mg IV q8hr for moderate renal impairment, 375mg IV q8hr for severe impairment
	**Pediatric		**Pediatric - N/A
	*Hepatic Dosing		*Hepatic Dosing
	**Adult		**Adult - N/A
	**Pediatric		**Pediatric - N/A

	==Contraindications==		==Contraindications==
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	==Pharmacology==		==Pharmacology==
	*Half-life:		*Half-life:
	*Metabolism:		*Metabolism: N/A
	*Excretion:		*Excretion: Renal (100%)
	*Mechanism of Action:		*Mechanism of Action:

	[[Category:ID]]		[[Category:ID]]

Zipdoc at 04:06, 26 June 2017

2017-06-26T04:06:40Z

← Older revision		Revision as of 04:06, 26 June 2017
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	*Excretion:		*Excretion:
	*Mechanism of Action:		*Mechanism of Action:
			[[Category:ID]]

Kxl328: Created page with "==General== Type: Dosage Forms: Common Trade Names: ==Adult Dosing== ==Pediatric Dosing== ==Special Populations== Pregnancy Rating: *Lac..."

2017-06-25T20:22:09Z

Created page with "==General== *Type: *Dosage Forms: *Common Trade Names: ==Adult Dosing== ==Pediatric Dosing== ==Special Populations== *Pregnancy Rating: *Lac..."

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