Cholestasis of pregnancy - Revision history

Ostermayer: Marked this version for translation

2026-01-07T12:30:43Z

Marked this version for translation

← Older revision		Revision as of 12:30, 7 January 2026
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	<translate>		<translate>

	==Background==		==Background== <!--T:1-->

			<!--T:2-->
	*Caused by combination of hormonal, genetic, and environmental factors --> impaired bile flow --> deposition of bile salts in skin and placenta		*Caused by combination of hormonal, genetic, and environmental factors --> impaired bile flow --> deposition of bile salts in skin and placenta
	*May predispose mothers to [[Special:MyLanguage/vitamin K deficiency\|vitamin K deficiency]] and increase risk of preterm delivery, [[Special:MyLanguage/IUFD\|IUFD]], and neonatal [[Special:MyLanguage/respiratory distress syndrome\|respiratory distress syndrome]]<ref>http://bestpractice.bmj.com/topics/en-us/800</ref>		*May predispose mothers to [[Special:MyLanguage/vitamin K deficiency\|vitamin K deficiency]] and increase risk of preterm delivery, [[Special:MyLanguage/IUFD\|IUFD]], and neonatal [[Special:MyLanguage/respiratory distress syndrome\|respiratory distress syndrome]]<ref>http://bestpractice.bmj.com/topics/en-us/800</ref>
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	==Clinical Features==		==Clinical Features== <!--T:3-->

			<!--T:4-->
	*Typically develops in late second and/or 3rd trimester		*Typically develops in late second and/or 3rd trimester
	*Rapidly resolves after delivery		*Rapidly resolves after delivery
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	==Differential Diagnosis==		==Differential Diagnosis== <!--T:5-->

	</translate>		</translate>
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	===Pregnancy-specific pruritus===		===Pregnancy-specific pruritus=== <!--T:6-->

			<!--T:7-->
	''see also: [[Special:MyLanguage/Rashes of pregnancy\|Rashes of pregnancy]]''		''see also: [[Special:MyLanguage/Rashes of pregnancy\|Rashes of pregnancy]]''
	*Pruritus gravidarum		*Pruritus gravidarum
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	==Evaluation==		==Evaluation== <!--T:8-->

			<!--T:9-->
	*CBC (rule out thrombocytopenia)		*CBC (rule out thrombocytopenia)
	*[[Special:MyLanguage/LFTs\|LFTs]]		*[[Special:MyLanguage/LFTs\|LFTs]]
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	==Management==		==Management== <!--T:10-->

			<!--T:11-->
	*Ursodeoxycholic acid ([[Special:MyLanguage/ursodiol\|ursodiol]]) 300mg TID until delivery		*Ursodeoxycholic acid ([[Special:MyLanguage/ursodiol\|ursodiol]]) 300mg TID until delivery
	*OBGYN follow-up		*OBGYN follow-up


	==Disposition==		==Disposition== <!--T:12-->

			<!--T:13-->
	*Discharge with OBGYN follow-up		*Discharge with OBGYN follow-up


	==See Also==		==See Also== <!--T:14-->


	==External Links==		==External Links== <!--T:15-->


	==References==		==References== <!--T:16-->

			<!--T:17-->
	https://www.uptodate.com/contents/intrahepatic-cholestasis-of-pregnancy		https://www.uptodate.com/contents/intrahepatic-cholestasis-of-pregnancy
	<references/>		<references/>
	[[Category:OBGYN]] [[Category:GI]]		[[Category:OBGYN]] [[Category:GI]]
	</translate>		</translate>

Ostermayer: Prepared the page for translation

2026-01-04T21:48:11Z

Prepared the page for translation

← Older revision		Revision as of 21:48, 4 January 2026
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			<languages/>
			<translate>

	==Background==		==Background==

	*Caused by combination of hormonal, genetic, and environmental factors --> impaired bile flow --> deposition of bile salts in skin and placenta		*Caused by combination of hormonal, genetic, and environmental factors --> impaired bile flow --> deposition of bile salts in skin and placenta
	*May predispose mothers to [[vitamin K deficiency]] and increase risk of preterm delivery, [[IUFD]], and neonatal [[respiratory distress syndrome]]<ref>http://bestpractice.bmj.com/topics/en-us/800</ref>		*May predispose mothers to [[Special:MyLanguage/vitamin K deficiency\|vitamin K deficiency]] and increase risk of preterm delivery, [[Special:MyLanguage/IUFD\|IUFD]], and neonatal [[Special:MyLanguage/respiratory distress syndrome\|respiratory distress syndrome]]<ref>http://bestpractice.bmj.com/topics/en-us/800</ref>

			</translate>
	{{Gallbladder disease types}}		{{Gallbladder disease types}}
			<translate>


	==Clinical Features==		==Clinical Features==

	*Typically develops in late second and/or 3rd trimester		*Typically develops in late second and/or 3rd trimester
	*Rapidly resolves after delivery		*Rapidly resolves after delivery
	*[[Pruritus]], starts and predominates on palms and soles		*[[Special:MyLanguage/Pruritus\|Pruritus]], starts and predominates on palms and soles
	*[[RUQ pain]]		*[[Special:MyLanguage/RUQ pain\|RUQ pain]]
	*[[Nausea]]		*[[Special:MyLanguage/Nausea\|Nausea]]
	*[[Jaundice]]		*[[Special:MyLanguage/Jaundice\|Jaundice]]


	==Differential Diagnosis==		==Differential Diagnosis==

			</translate>
	{{Jaundice DDX}}		{{Jaundice DDX}}
			<translate>


	===Pregnancy-specific pruritus===		===Pregnancy-specific pruritus===
	''see also: [[Rashes of pregnancy]]''
			''see also: [[Special:MyLanguage/Rashes of pregnancy\|Rashes of pregnancy]]''
	*Pruritus gravidarum		*Pruritus gravidarum
	*Atopic eruption of pregnancy		*Atopic eruption of pregnancy
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	*Prurigo of pregnancy		*Prurigo of pregnancy
	*Pruritic folliculitis of pregnancy		*Pruritic folliculitis of pregnancy


	==Evaluation==		==Evaluation==

	*CBC (rule out thrombocytopenia)		*CBC (rule out thrombocytopenia)
	*[[LFTs]]		*[[Special:MyLanguage/LFTs\|LFTs]]
	**Elevated total bile acid concentration		**Elevated total bile acid concentration
	**Aminotransferases usually <2x upper limit of normal		**Aminotransferases usually <2x upper limit of normal
	**Alk phos and bili may be elevated		**Alk phos and bili may be elevated
	**GGT normal or modestly elevated		**GGT normal or modestly elevated
	**[[RUQ US]] normal, no biliary duct dilation		**[[Special:MyLanguage/RUQ US\|RUQ US]] normal, no biliary duct dilation


	==Management==		==Management==
	*Ursodeoxycholic acid ([[ursodiol]]) 300mg TID until delivery
			*Ursodeoxycholic acid ([[Special:MyLanguage/ursodiol\|ursodiol]]) 300mg TID until delivery
	*OBGYN follow-up		*OBGYN follow-up


	==Disposition==		==Disposition==

	*Discharge with OBGYN follow-up		*Discharge with OBGYN follow-up


	==See Also==		==See Also==
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	==References==		==References==

	https://www.uptodate.com/contents/intrahepatic-cholestasis-of-pregnancy		https://www.uptodate.com/contents/intrahepatic-cholestasis-of-pregnancy
	<references/>		<references/>
	[[Category:OBGYN]] [[Category:GI]]		[[Category:OBGYN]] [[Category:GI]]
			</translate>

Rossdonaldson1: /* Background */

2024-02-28T23:38:33Z

Background

← Older revision		Revision as of 23:38, 28 February 2024
Line 2:		Line 2:
	*Caused by combination of hormonal, genetic, and environmental factors --> impaired bile flow --> deposition of bile salts in skin and placenta		*Caused by combination of hormonal, genetic, and environmental factors --> impaired bile flow --> deposition of bile salts in skin and placenta
	*May predispose mothers to [[vitamin K deficiency]] and increase risk of preterm delivery, [[IUFD]], and neonatal [[respiratory distress syndrome]]<ref>http://bestpractice.bmj.com/topics/en-us/800</ref>		*May predispose mothers to [[vitamin K deficiency]] and increase risk of preterm delivery, [[IUFD]], and neonatal [[respiratory distress syndrome]]<ref>http://bestpractice.bmj.com/topics/en-us/800</ref>

			{{Gallbladder disease types}}

	==Clinical Features==		==Clinical Features==

Rossdonaldson1: /* Differential Diagnosis */

2021-11-25T13:41:43Z

Differential Diagnosis

@@ Line 12: / Line 12: @@
 ==Differential Diagnosis==
-*Liver disease in pregnancy:
+{{Jaundice DDX}}
-{{Jaundice DDX}}
+===Pregnancy-specific pruritus===
 ==Evaluation==

Rossdonaldson1: /* Differential Diagnosis */

2021-11-25T13:36:49Z

Differential Diagnosis

← Older revision		Revision as of 13:36, 25 November 2021
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	**Prurigo of pregnancy		**Prurigo of pregnancy
	**Pruritic folliculitis of pregnancy		**Pruritic folliculitis of pregnancy

			{{Jaundice DDX}}

	==Evaluation==		==Evaluation==

ClaireLewis: /* Differential Diagnosis */

2019-08-23T19:19:42Z

Differential Diagnosis

← Older revision		Revision as of 19:19, 23 August 2019
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	==Differential Diagnosis==		==Differential Diagnosis==
	*Liver disease in pregnancy:		*Liver disease in pregnancy:
	**Acute fatty liver of pregnancy		**[[Acute fatty liver of pregnancy]]
	**[[HELLP]] (hemolysis, elevated liver enzymes, and low platelets) syndrome		**[[HELLP]] (hemolysis, elevated liver enzymes, and low platelets) syndrome
	**[[Hyperemesis gravidarum]]		**[[Hyperemesis gravidarum]]

ClaireLewis at 19:56, 21 August 2019

2019-08-21T19:56:42Z

← Older revision		Revision as of 19:56, 21 August 2019
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	==Background==		==Background==
	*~~characterized~~ by ~~pruritus~~ and ~~elevation in serum~~ bile ~~acid concentrations, typically developing~~ in ~~late second~~ and~~/or third trimester~~ and ~~rapidly resolving after~~ delivery		*Caused by combination of hormonal, genetic, and environmental factors --> impaired bile flow --> deposition of bile salts in skin and placenta
			*May predispose mothers to [[vitamin K deficiency]] and increase risk of preterm delivery, [[IUFD]], and neonatal [[respiratory distress syndrome]]<ref>http://bestpractice.bmj.com/topics/en-us/800</ref>

	==Clinical Features==		==Clinical Features==
	*~~pruritus~~, starts and predominates on palms and soles		*Typically develops in late second and/or 3rd trimester
	*RUQ ~~abd~~ pain		*Rapidly resolves after delivery
	*Nausea		*[[Pruritus]], starts and predominates on palms and soles
	*Jaundice		*[[RUQ pain]]
			*[[Nausea]]
			*[[Jaundice]]

	==Differential Diagnosis==		==Differential Diagnosis==
	*Liver disease in pregnancy		*Liver disease in pregnancy:
	**~~acute~~ fatty liver of pregnancy		**Acute fatty liver of pregnancy
	**hemolysis, elevated liver enzymes and low platelets syndrome		**[[HELLP]] (hemolysis, elevated liver enzymes, and low platelets) syndrome
	**~~hyperemesis~~ gravidarum		**[[Hyperemesis gravidarum]]
	*Pregnancy specific pruritus		*Pregnancy-specific pruritus (see also: [[Rashes of pregnancy]])
	**Pruritus gravidarum		**Pruritus gravidarum
	**Atopic eruption of pregnancy		**Atopic eruption of pregnancy
	**Polymorphic eruption of pregnancy		**Polymorphic eruption of pregnancy
	**Pemphigoid ~~gestations~~		**Pemphigoid gestationis
	**Prurigo of pregnancy		**Prurigo of pregnancy
	**Pruritic folliculitis of pregnancy		**Pruritic folliculitis of pregnancy

	==Evaluation==		==Evaluation==
	*~~increase in serum~~ total bile acid concentration		*CBC (rule out thrombocytopenia)
	*~~increase in serum aminotransferases~~ usually ~~less than two times~~ upper limit of normal		*[[LFTs]]
	*~~alk~~ phos and bili ~~can~~ be elevated ~~as well~~		**Elevated total bile acid concentration
	*GGT is normal or modestly elevated		**Aminotransferases usually <2x upper limit of normal
	*US is normal, biliary ~~ducts not dilated~~		**Alk phos and bili may be elevated
			**GGT normal or modestly elevated
			**[[RUQ US]] normal, no biliary duct dilation

	==Management==		==Management==
	*Ursodeoxycholic acid 300mg TID until delivery		*Ursodeoxycholic acid ([[ursodiol]]) 300mg TID until delivery
	*OBGYN follow-up		*OBGYN follow-up

	==Disposition==		==Disposition==
	*~~home~~ with OBGYN follow-up		*Discharge with OBGYN follow-up

	==See Also==		==See Also==
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	https://www.uptodate.com/contents/intrahepatic-cholestasis-of-pregnancy		https://www.uptodate.com/contents/intrahepatic-cholestasis-of-pregnancy
	<references/>		<references/>
			[[Category:OBGYN]] [[Category:GI]]

Gregtong: Created page with "==Background== *characterized by pruritus and elevation in serum bile acid concentrations, typically developing in late second and/or third trimester and rapidly resolving aft..."

2019-08-21T02:18:11Z

Created page with "==Background== *characterized by pruritus and elevation in serum bile acid concentrations, typically developing in late second and/or third trimester and rapidly resolving aft..."

New page

==Background==
*characterized by pruritus and elevation in serum bile acid concentrations, typically developing in late second and/or third trimester and rapidly resolving after delivery

==Clinical Features==
*pruritus, starts and predominates on palms and soles
*RUQ abd pain
*Nausea
*Jaundice

==Differential Diagnosis==
*Liver disease in pregnancy
**acute fatty liver of pregnancy
**hemolysis, elevated liver enzymes and low platelets syndrome
**hyperemesis gravidarum
*Pregnancy specific pruritus
**Pruritus gravidarum
**Atopic eruption of pregnancy
**Polymorphic eruption of pregnancy
**Pemphigoid gestations
**Prurigo of pregnancy
**Pruritic folliculitis of pregnancy

==Evaluation==
*increase in serum total bile acid concentration
*increase in serum aminotransferases usually less than two times upper limit of normal
*alk phos and bili can be elevated as well
*GGT is normal or modestly elevated
*US is normal, biliary ducts not dilated

==Management==
*Ursodeoxycholic acid 300mg TID until delivery
*OBGYN follow-up

==Disposition==
*home with OBGYN follow-up

==See Also==

==External Links==

==References==
https://www.uptodate.com/contents/intrahepatic-cholestasis-of-pregnancy
<references/>