https://wikem.org/w/index.php?action=history&feed=atom&title=Cholestasis_of_pregnancy%2Fen 2026-04-19T22:01:47Z Revision history for this page on the wiki MediaWiki 1.38.2 https://wikem.org/w/index.php?title=Cholestasis_of_pregnancy/en&diff=380866&oldid=prev 2026-01-07T13:36:39Z

<p>Updating to match new version of source page</p> <p><b>New page</b></p><div>&lt;languages/&gt;<br /> <br /> ==Background==<br /> <br /> *Caused by combination of hormonal, genetic, and environmental factors --&gt; impaired bile flow --&gt; deposition of bile salts in skin and placenta<br /> *May predispose mothers to [[Special:MyLanguage/vitamin K deficiency|vitamin K deficiency]] and increase risk of preterm delivery, [[Special:MyLanguage/IUFD|IUFD]], and neonatal [[Special:MyLanguage/respiratory distress syndrome|respiratory distress syndrome]]&lt;ref&gt;http://bestpractice.bmj.com/topics/en-us/800&lt;/ref&gt;<br /> <br /> {{Gallbladder disease types}}<br /> <br /> <br /> ==Clinical Features==<br /> <br /> *Typically develops in late second and/or 3rd trimester<br /> *Rapidly resolves after delivery<br /> *[[Special:MyLanguage/Pruritus|Pruritus]], starts and predominates on palms and soles<br /> *[[Special:MyLanguage/RUQ pain|RUQ pain]]<br /> *[[Special:MyLanguage/Nausea|Nausea]]<br /> *[[Special:MyLanguage/Jaundice|Jaundice]]<br /> <br /> <br /> ==Differential Diagnosis==<br /> <br /> {{Jaundice DDX}}<br /> <br /> <br /> ===Pregnancy-specific pruritus===<br /> <br /> ''see also: [[Special:MyLanguage/Rashes of pregnancy|Rashes of pregnancy]]''<br /> *Pruritus gravidarum<br /> *Atopic eruption of pregnancy<br /> *Polymorphic eruption of pregnancy<br /> *Pemphigoid gestationis<br /> *Prurigo of pregnancy<br /> *Pruritic folliculitis of pregnancy<br /> <br /> <br /> ==Evaluation==<br /> <br /> *CBC (rule out thrombocytopenia)<br /> *[[Special:MyLanguage/LFTs|LFTs]]<br /> **Elevated total bile acid concentration<br /> **Aminotransferases usually &lt;2x upper limit of normal<br /> **Alk phos and bili may be elevated<br /> **GGT normal or modestly elevated<br /> **[[Special:MyLanguage/RUQ US|RUQ US]] normal, no biliary duct dilation<br /> <br /> <br /> ==Management==<br /> <br /> *Ursodeoxycholic acid ([[Special:MyLanguage/ursodiol|ursodiol]]) 300mg TID until delivery<br /> *OBGYN follow-up<br /> <br /> <br /> ==Disposition==<br /> <br /> *Discharge with OBGYN follow-up<br /> <br /> <br /> ==See Also==<br /> <br /> <br /> ==External Links==<br /> <br /> <br /> ==References==<br /> <br /> https://www.uptodate.com/contents/intrahepatic-cholestasis-of-pregnancy<br /> &lt;references/&gt;<br /> [[Category:OBGYN]] [[Category:GI]]</div>

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