Clozapine - Revision history

Elcatracho: /* See Also */

2021-03-07T04:08:44Z

2019-09-20T17:46:57Z

← Older revision		Revision as of 17:46, 20 September 2019
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	*[[Bipolar disorder]]		*[[Bipolar disorder]]
	*[[Borderline personality disorder]]		*[[Borderline personality disorder]]
	*[[~~Antipsychotic Medications~~]]		*[[Antipsychotics]]

	==References==		==References==

2019-01-26T21:37:39Z

Pediatric Dosing

← Older revision		Revision as of 21:37, 26 January 2019
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	==Pediatric Dosing==		==Pediatric Dosing==
	*~~not available~~		*Schizophrenia (limited data - adjusted dose based on tolerability, clinical response)
			** Children >6 years PO 6.25 or 12.5mg qd
			** Adolescents 12.5mg 1-2x daily

	==Special Populations==		==Special Populations==

2017-07-24T01:12:29Z

Text replacement - "alpha" to "α"

← Older revision		Revision as of 01:12, 24 July 2017
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	*Metabolism: liver extensively		*Metabolism: liver extensively
	*Excretion: urine 50%, feces 30%		*Excretion: urine 50%, feces 30%
	*Mechanism of Action: exact mechanism of action unknown, antagonizes dopamine D2, serotonin 5-HT2, ~~alpha~~ adrenergic, cholinergic muscarinic receptors, others		*Mechanism of Action: exact mechanism of action unknown, antagonizes dopamine D2, serotonin 5-HT2, α adrenergic, cholinergic muscarinic receptors, others

	==See Also==		==See Also==

2017-07-07T11:51:28Z

Text replacement - "qd" to "QD"

← Older revision		Revision as of 11:51, 7 July 2017
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	===[[Schizophrenia]], resistant===		===[[Schizophrenia]], resistant===
	*150-300mg PO BID		*150-300mg PO BID
	*start: 12.5mg PO qd-bid, increase by 25-50mg/day to target 300-450mg/day in divided doses by day 14; then may increase by up to 100mg/day q3-7days;		*start: 12.5mg PO QD-bid, increase by 25-50mg/day to target 300-450mg/day in divided doses by day 14; then may increase by up to 100mg/day q3-7days;
	*max 900mg/day		*max 900mg/day
	*retitrate from 12.5mg PO qd-bid if treatment interrupted > 2 d		*retitrate from 12.5mg PO QD-bid if treatment interrupted > 2 d
	*taper dose over 1-2 weeks to DC		*taper dose over 1-2 weeks to DC

2016-07-30T03:44:17Z

General

← Older revision		Revision as of 03:44, 30 July 2016
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	==General==		==General==
	*Type: Atypical antipsychotic		*Type: Atypical [[antipsychotic]]
	*Dosage Forms:		*Dosage Forms:
	**12.5, 25, 50, 100, 200		**12.5, 25, 50, 100, 200

2016-07-18T12:28:05Z

Text replacement - "MOI" to "mechanism of action"

← Older revision		Revision as of 12:28, 18 July 2016
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	*Metabolism: liver extensively		*Metabolism: liver extensively
	*Excretion: urine 50%, feces 30%		*Excretion: urine 50%, feces 30%
	*Mechanism of Action: exact ~~MOI~~ unknown, antagonizes dopamine D2, serotonin 5-HT2, alpha adrenergic, cholinergic muscarinic receptors, others		*Mechanism of Action: exact mechanism of action unknown, antagonizes dopamine D2, serotonin 5-HT2, alpha adrenergic, cholinergic muscarinic receptors, others

	==See Also==		==See Also==

2016-07-14T01:54:02Z

Contraindications

← Older revision		Revision as of 01:54, 14 July 2016
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	==Contraindications==		==Contraindications==
	*Allergy to class/drug		*Allergy to class/drug
	*~~h/o~~ clozapine-associated myocarditis		*history of clozapine-associated myocarditis
	*~~h/o~~ agranulocytosis or granulocytopenia		*history of agranulocytosis or granulocytopenia
	*uncorrected electrolyte abnormalities		*uncorrected electrolyte abnormalities
	*caution in elderly, stroke, dementia, CAD, prolonged QT		*caution in elderly, stroke, dementia, CAD, prolonged QT
	*caution if ~~h/o~~ torsades de pointes, ventricular arrhythmias		*caution if history of torsades de pointes, ventricular arrhythmias
	*caution if bradycardic, recent MI, CHF		*caution if bradycardic, recent MI, CHF
	*caution if eosinophila		*caution if eosinophila

2016-03-22T16:02:58Z

Text replacement - "Category:Psych" to "Category:Psychiatry"

2016-03-22T15:54:33Z

Text replacement - "Category:Drugs" to "Category:Pharmacology"

← Older revision		Revision as of 04:08, 7 March 2021
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	*[[Borderline personality disorder]]		*[[Borderline personality disorder]]
	*[[Antipsychotics]]		*[[Antipsychotics]]
			*[[Antipsychotic toxicity]]

	==References==		==References==