Coronavirus - Revision history

Elcatracho: /* Prevention */

2021-03-06T23:41:18Z

Prevention

← Older revision		Revision as of 23:41, 6 March 2021
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	==Prevention==		==Prevention==
	*No vaccines ~~have been made thus far to prevent Coronavirus.~~		*The first vaccines produced against a coronavirus were developed during the [[COVID-19]] pandemic
	*Measures to reduce risk of transmission: fully wash hands, do not touch face without washing hands, avoid close contact with sick contacts.		*Measures to reduce risk of transmission: fully wash hands, do not touch face without washing hands, avoid close contact with sick contacts.

	==See Also==		==See Also==

LouisTran: /* Background */

2020-04-13T06:16:36Z

Background

← Older revision		Revision as of 06:16, 13 April 2020
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	==Background==		==Background==
	*Enveloped, positive-stranded RNA viruses with nucleocapsid		* Enveloped, positive-sense single-stranded RNA viruses with nucleocapsid
	*Very common cause of [[upper respiratory infection]], especially during fall and winter, and some diarrhea in pediatric patients		* Very common cause of [[upper respiratory infection]], especially during fall and winter, and some diarrhea in pediatric patients
			* Emerging pathogen for respiratory disease outbreaks
			* Probably originated from bats, then spread to other mammalian hosts
			** [[SARS]]-CoV – Himalayan palm civets
			** [[MERS]]-CoV – Dromedary camels
			** [[COVID-19\|SARS-CoV-2]] – Suspected to be from pangolins

	{{Specific Coronavirus Sub-Types of Clinical Importance}}		{{Specific Coronavirus Sub-Types of Clinical Importance}}

Ktanner777: /* Evaluation */

2020-03-31T17:53:39Z

Evaluation

← Older revision		Revision as of 17:53, 31 March 2020
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	==Evaluation==		==Evaluation==
	*[[Laboratory Abnormalities]]
	*PCR Testing		*PCR Testing
	**Should be obtained on nasopharyngeal swab preferably one with synthetic fibers and plastic tip and under isolation		**Should be obtained on nasopharyngeal swab preferably one with synthetic fibers and plastic tip and under isolation
	**Criteria for who to test is constantly evolving at this time. The CDC currently recommends clinicians to refer to local and/or institutional guidelines and test availability when deciding who should be tested.		**Criteria for who to test is constantly evolving at this time. The CDC currently recommends clinicians to refer to local and/or institutional guidelines and test availability when deciding who should be tested.
			*Laboratory Abnormalities
	**Lymphocytosis		**Lymphocytosis
	***Present in 70-80% of patients<ref>Wang D, Hu B, Hu C, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China [published online ahead of print, 2020 Feb 7]. JAMA. 2020;10.1001/jama.2020.1585. doi:10.1001/jama.2020.1585</ref>		***Present in 70-80% of patients<ref name="clinical characteristics">Wang D, Hu B, Hu C, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China [published online ahead of print, 2020 Feb 7]. JAMA. 2020;10.1001/jama.2020.1585. doi:10.1001/jama.2020.1585</ref>
	***Severity of lymphocytosis and leukopenia shown to be associated with severe of illness<ref>Wang D, Hu B, Hu C, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China [published online ahead of print, 2020 Feb 7]. JAMA. 2020;10.1001/jama.2020.1585. doi:10.1001/jama.2020.1585</ref><ref>Wei-jie Guan, Ph.D., Zheng-yi Ni, M.D., Yu Hu, M.D., et al. Clinical Characteristics of Coronavirus Disease 2019 in China. China Medical Treatment Expert Group for Covid-19. The New England Journal Of Medicine website. https://www.nejm.org/doi/full/10.1056/NEJMoa2002032 Published February 28, 2020. Accessed March 31, 2020</ref>		***Severity of lymphocytosis and leukopenia shown to be associated with severe of illness<ref name="clinical characteristics"></ref><ref name="disease 2019">Wei-jie Guan, Ph.D., Zheng-yi Ni, M.D., Yu Hu, M.D., et al. Clinical Characteristics of Coronavirus Disease 2019 in China. China Medical Treatment Expert Group for Covid-19. The New England Journal Of Medicine website. https://www.nejm.org/doi/full/10.1056/NEJMoa2002032 Published February 28, 2020. Accessed March 31, 2020</ref>
	**Thrombocytopenia, elevated lactate dehydrogenase, elevated C-reactive protein, and prolonged prothrombin time have been reported<ref>Wei-jie Guan, Ph.D., Zheng-yi Ni, M.D., Yu Hu, M.D., et al. Clinical Characteristics of Coronavirus Disease 2019 in China. China Medical Treatment Expert Group for Covid-19. The New England Journal Of Medicine website. https://www.nejm.org/doi/full/10.1056/NEJMoa2002032 Published February 28, 2020. Accessed March 31, 2020</ref><ref>Wang D, Hu B, Hu C, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China [published online ahead of print, 2020 Feb 7]. JAMA. 2020;10.1001/jama.2020.1585. doi:10.1001/jama.2020.1585</ref>		**Thrombocytopenia, elevated lactate dehydrogenase, elevated C-reactive protein, and prolonged prothrombin time have been reported<ref name="clinical characteristics"></ref><ref name="disease 2019"></ref>

	==Management==		==Management==

Ktanner777: /* Evaluation */

2020-03-31T17:39:37Z

Evaluation

← Older revision		Revision as of 17:39, 31 March 2020
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	==Evaluation==		==Evaluation==
	*~~Generally no testing indicated~~		*[[Laboratory Abnormalities]]
	*~~If needed~~, ~~nasal swabs can~~ be ~~sent~~ for ~~PCR~~ and ~~immunofluorescent antigen assay~~		*PCR Testing
			**Should be obtained on nasopharyngeal swab preferably one with synthetic fibers and plastic tip and under isolation
			**Criteria for who to test is constantly evolving at this time. The CDC currently recommends clinicians to refer to local and/or institutional guidelines and test availability when deciding who should be tested.
			**Lymphocytosis
			***Present in 70-80% of patients<ref>Wang D, Hu B, Hu C, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China [published online ahead of print, 2020 Feb 7]. JAMA. 2020;10.1001/jama.2020.1585. doi:10.1001/jama.2020.1585</ref>
			***Severity of lymphocytosis and leukopenia shown to be associated with severe of illness<ref>Wang D, Hu B, Hu C, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China [published online ahead of print, 2020 Feb 7]. JAMA. 2020;10.1001/jama.2020.1585. doi:10.1001/jama.2020.1585</ref><ref>Wei-jie Guan, Ph.D., Zheng-yi Ni, M.D., Yu Hu, M.D., et al. Clinical Characteristics of Coronavirus Disease 2019 in China. China Medical Treatment Expert Group for Covid-19. The New England Journal Of Medicine website. https://www.nejm.org/doi/full/10.1056/NEJMoa2002032 Published February 28, 2020. Accessed March 31, 2020</ref>
			**Thrombocytopenia, elevated lactate dehydrogenase, elevated C-reactive protein, and prolonged prothrombin time have been reported<ref>Wei-jie Guan, Ph.D., Zheng-yi Ni, M.D., Yu Hu, M.D., et al. Clinical Characteristics of Coronavirus Disease 2019 in China. China Medical Treatment Expert Group for Covid-19. The New England Journal Of Medicine website. https://www.nejm.org/doi/full/10.1056/NEJMoa2002032 Published February 28, 2020. Accessed March 31, 2020</ref><ref>Wang D, Hu B, Hu C, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China [published online ahead of print, 2020 Feb 7]. JAMA. 2020;10.1001/jama.2020.1585. doi:10.1001/jama.2020.1585</ref>

	==Management==		==Management==

Rossdonaldson1: /* See Also */

2020-03-21T11:24:44Z

Rossdonaldson1: /* Background */

2020-01-29T00:02:06Z

Background

← Older revision		Revision as of 00:02, 29 January 2020
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	*Very common cause of [[upper respiratory infection]], especially during fall and winter, and some diarrhea in pediatric patients		*Very common cause of [[upper respiratory infection]], especially during fall and winter, and some diarrhea in pediatric patients

	~~===~~Specific Sub-Types of Clinical Importance~~===~~		{{Specific Coronavirus Sub-Types of Clinical Importance}}
	*[[MERS]]-CoV
	*[[SARS]]-CoV
	*[[2019-nCoV]] (2019 Novel Coronavirus; Wu Han)

	==Clinical Features==		==Clinical Features==

Rossdonaldson1: /* Specific Sub-Types of Clinical Importance */

2020-01-29T00:00:22Z

Specific Sub-Types of Clinical Importance

← Older revision		Revision as of 00:00, 29 January 2020
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	*[[MERS]]-CoV		*[[MERS]]-CoV
	*[[SARS]]-CoV		*[[SARS]]-CoV
	*nCoV-2019 (Wu Han)		*[[2019-nCoV]] (2019 Novel Coronavirus; Wu Han)

	==Clinical Features==		==Clinical Features==

Rossdonaldson1: /* Background */

2020-01-28T23:59:12Z

Background

← Older revision		Revision as of 23:59, 28 January 2020
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	*Enveloped, positive-stranded RNA viruses with nucleocapsid		*Enveloped, positive-stranded RNA viruses with nucleocapsid
	*Very common cause of [[upper respiratory infection]], especially during fall and winter, and some diarrhea in pediatric patients		*Very common cause of [[upper respiratory infection]], especially during fall and winter, and some diarrhea in pediatric patients
	*[[MERS]]-CoV ~~and~~ [[SARS]]-CoV ~~types of Coronavirus cause the most severe infections.~~
			===Specific Sub-Types of Clinical Importance===
			*[[MERS]]-CoV
			*[[SARS]]-CoV
			*nCoV-2019 (Wu Han)

	==Clinical Features==		==Clinical Features==

ClaireLewis at 20:27, 22 October 2019

2019-10-22T20:27:07Z

← Older revision		Revision as of 20:27, 22 October 2019
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	*Incubation period: 2-4 days		*Incubation period: 2-4 days
	*Upper respiratory symptoms		*Upper respiratory symptoms
	**~~rhinorrhea~~, [[cough]], [[sore throat]], earache, [[fever]], malaise		**[[Rhinorrhea]], [[cough]], [[sore throat]], earache, [[fever]], malaise
	**Respiratory symptoms may be more severe in elderly/immunocompromised (e.g. [[pneumonia]], secondary bacterial [[pneumonia]])		**Respiratory symptoms may be more severe in elderly/immunocompromised (e.g. [[pneumonia]], secondary bacterial [[pneumonia]])
	*GI symptoms - [[vomiting]], [[diarrhea]], [[Necrotizing enterocolitis]] (in neonates)		*GI symptoms - [[vomiting]], [[diarrhea]], [[Necrotizing enterocolitis]] (in neonates)

ClaireLewis: /* Management */

2019-09-24T17:38:33Z

Management

← Older revision		Revision as of 17:38, 24 September 2019
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	*There is no specific treatment for Coronavirus, since most infections spontaneously resolve.		*There is no specific treatment for Coronavirus, since most infections spontaneously resolve.
	*Supportive care, no specific treatment		*Supportive care, no specific treatment
	**Rest, hydration, analgesia, antipyretics		**Rest, hydration, [[analgesia]], antipyretics
	*Hand hygiene to prevent spread		*Hand hygiene to prevent spread

← Older revision		Revision as of 11:24, 21 March 2020
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	*[[Upper respiratory infection]]		*[[Upper respiratory infection]]
	*[[Fever]]		*[[Fever]]
			*[[COVID-19]]

	==External Links==		==External Links==