Danbot: Created Dabigatran medication page with dosing (replacing redirect to Dabigatran reversal); added SMW Indications by Condition query

2026-03-25T01:10:07Z

Created Dabigatran medication page with dosing (replacing redirect to Dabigatran reversal); added SMW Indications by Condition query

← Older revision		Revision as of 01:10, 25 March 2026
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	#~~REDIRECT~~[[Dabigatran reversal]]		==Administration==
			*Type: [[Anticoagulant]], Direct Thrombin Inhibitor
			*Dosage Forms: capsule
			*Dosage Strengths: 75mg, 110mg, 150mg
			*Routes of Administration: Oral
			*Common Trade Names: Pradaxa

			==Adult Dosing==
			===Stroke prevention in [[atrial fibrillation]] (nonvalvular)===
			*150mg PO BID (CrCl >30)
			*75mg PO BID (CrCl 15-30)

			===[[DVT]]/[[PE]] Treatment===
			*150mg PO BID after 5-10 days of parenteral anticoagulation

			===[[DVT]]/[[PE]] Prophylaxis (post hip replacement)===
			*110mg PO on day of surgery (1-4h post-op), then 220mg PO QD x28-35 days

			==Pediatric Dosing==
			''Safety/efficacy not established''

			==Special Populations==
			*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: C
			*[[Lactation risk categories\|Lactation risk]]: Infant risk cannot be ruled out
			*Renal dosing:
			**Afib: 75mg BID if CrCl 15-30; avoid if CrCl <15
			**DVT/PE treatment: avoid if CrCl <30
			*Hepatic dosing: No adjustment required; avoid in severe impairment
			*Decrease dose if concomitant use of P-gp inhibitors (e.g., dronedarone, systemic ketoconazole) with CrCl 30-50

			==Contraindications==
			*Allergy to class/drug
			*Active pathological bleeding
			*Mechanical prosthetic heart valve
			*CrCl <30 (DVT/PE treatment)
			*Concomitant use of P-gp inhibitors with CrCl <30

			==Adverse Reactions==
			===Serious===
			*[[Anticoagulant reversal for life-threatening bleeds\|Bleeding, severe]]
			**[[Idarucizumab]] (Praxbind): specific reversal agent
			*Epidural/[[spinal hematoma]]
			*GI hemorrhage

			===Common===
			*Dyspepsia, GI discomfort (most common reason for discontinuation)
			*Easy bruising, epistaxis

			==Pharmacology==
			*Half-life: 12-17 hours (prolonged with renal impairment)
			*Metabolism: Conjugation (not CYP450 dependent)
			*Excretion: 80% renal
			*Bioavailability: 3-7% (capsules must not be crushed or opened)

			==Mechanism of Action==
			*Direct, competitive, reversible inhibitor of free and clot-bound thrombin (factor IIa)

			==Comments==
			*Only NOAC with a specific reversal agent: [[Idarucizumab]] (Praxbind) 5g IV
			*Must be stored in original packaging (sensitive to moisture)
			*Cannot be crushed, chewed, or placed in feeding tubes (bioavailability changes dramatically)
			*Higher rate of GI bleeding compared to warfarin; lower rate of intracranial hemorrhage
			*aPTT provides qualitative assessment of anticoagulant effect; Thrombin Time (TT) is most sensitive — normal TT excludes significant drug effect
			*Dialyzable (~60% removed over 2-3h)

			==Indications by Condition==
			''The following table is automatically generated from disease/condition pages across WikEM.''
			{{#ask:[[Has DrugName::Dabigatran]]
			\|?Has Indication=Indication
			\|?Has Dose=Dose
			\|?Has Context=Context
			\|?Has Route=Route
			\|?Has Population=Population
			\|format=table
			\|headers=plain
			\|mainlabel=-
			\|sort=Has Indication
			\|limit=50
			}}

			==See Also==
			*[[Dabigatran reversal]]
			*[[Idarucizumab]]
			*[[Anticoagulant reversal for life-threatening bleeds]]
			*[[Procedures in patients with coagulopathies]]
			*[[Atrial fibrillation (main)]]

			==References==
			<references/>

			[[Category:Pharmacology]]

Neil.m.young: Redirected page to Dabigatran reversal

2015-12-27T02:15:07Z

Redirected page to Dabigatran reversal

← Older revision		Revision as of 02:15, 27 December 2015
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	#REDIRECT[[Dabigatran ~~(Pradaxa)~~ reversal]]		#REDIRECT[[Dabigatran reversal]]

Rossdonaldson1: Redirected page to Dabigatran (Pradaxa) reversal

2015-09-28T01:24:51Z

Redirected page to Dabigatran (Pradaxa) reversal

← Older revision		Revision as of 01:24, 28 September 2015
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	#REDIRECT[[Dabigatran (Pradaxa) ~~Reversal~~]]		#REDIRECT[[Dabigatran (Pradaxa) reversal]]

Rossdonaldson1: Redirected page to Dabigatran (Pradaxa) Reversal

2012-11-21T21:41:14Z

Redirected page to Dabigatran (Pradaxa) Reversal

← Older revision		Revision as of 21:41, 21 November 2012
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	#REDIRECT[[Dabigatran (Pradaxa)]]		#REDIRECT[[Dabigatran (Pradaxa) Reversal]]

Rossdonaldson1: Redirected page to Dabigatran (Pradaxa)

2012-06-11T21:05:18Z

Redirected page to Dabigatran (Pradaxa)

New page

#REDIRECT[[Dabigatran (Pradaxa)]]

Dabigatran - Revision history

Danbot: Created Dabigatran medication page with dosing (replacing redirect to Dabigatran reversal); added SMW Indications by Condition query

Neil.m.young: Redirected page to Dabigatran reversal

Rossdonaldson1: Redirected page to Dabigatran (Pradaxa) reversal

Rossdonaldson1: Redirected page to Dabigatran (Pradaxa) Reversal

Rossdonaldson1: Redirected page to Dabigatran (Pradaxa)