Deferoxamine - Revision history

Danbot: Fix cite error: add citation content to empty ironoverview named ref

2026-03-21T01:01:36Z

Fix cite error: add citation content to empty ironoverview named ref

← Older revision		Revision as of 01:01, 21 March 2026
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	==Comments==		==Comments==
	*Chelates iron and creates a water-soluble compound ferrioxamine that is renally excreted and can be dialyzed.<ref name="ironoverview"></ref>		*Chelates iron and creates a water-soluble compound ferrioxamine that is renally excreted and can be dialyzed.<ref name="ironoverview">Perrone J. Iron. In: Nelson LS, Howland MA, Lewin NA, et al., eds. Goldfrank's Toxicologic Emergencies. 11th ed. New York, NY: McGraw-Hill; 2019.</ref>

Danbot: Switch SMW query from broadtable to table format for better layout with TOC

2026-03-20T21:57:39Z

Switch SMW query from broadtable to table format for better layout with TOC

← Older revision		Revision as of 21:57, 20 March 2026
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	\|?Has Route=Route		\|?Has Route=Route
	\|?Has Population=Population		\|?Has Population=Population
	\|format=~~broadtable~~		\|format=table
	\|headers=plain		\|headers=plain
	\|mainlabel=-		\|mainlabel=-

Danbot: Add Indications by Condition SMW query table

2026-03-20T17:45:42Z

Add Indications by Condition SMW query table

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 ==Comments==
 *Chelates iron and creates a water-soluble compound ferrioxamine that is renally excreted and can be dialyzed.<ref name="ironoverview"></ref>
 ==See Also==

ClaireLewis: /* References */

2019-09-20T23:52:03Z

References

← Older revision		Revision as of 23:52, 20 September 2019
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	<references/>		<references/>
	[[Category:Pharmacology]]		[[Category:Pharmacology]]
			[[Category:Toxicology]]

Jonwarren: Updated links and information for pharmacology/side effects

2018-09-08T21:50:04Z

Updated links and information for pharmacology/side effects

← Older revision		Revision as of 21:50, 8 September 2018
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	==General==		==General==
	*Type:		*Type: [[Antidote]]
	*Dosage Forms:		*Dosage Forms:
	*Routes of Administration:		*Routes of Administration: IV, IM
	*Common Trade Names:		*Common Trade Names: Desferal

	==Adult Dosing==		==Adult Dosing==
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	==Pediatric Dosing==		==Pediatric Dosing==
			===[[Iron toxicity]]===
			*15 mg/kg/h IV
			*Prolonged use >24-48 hours may increase risk of ARDS
			*100mg deferoxamine chelates 9mg free iron

	==Special Populations==		==Special Populations==
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	*[[Lactation risk categories\|Lactation risk]]:		*[[Lactation risk categories\|Lactation risk]]:
	*Renal Dosing		*Renal Dosing
	**Adult		**Adult: Contraindicated in severe impairment or anuria.
	**Pediatric		**Pediatric: Contraindicated in severe impairment or anuria
	*Hepatic Dosing		*Hepatic Dosing
	**Adult		**Adult: Not defined
	**Pediatric		**Pediatric: Not defined

	==Indications==		==Indications==
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	deferoxamine therapy. Dig Dis Sci 1991; 36:1154-1160.</ref>		deferoxamine therapy. Dig Dis Sci 1991; 36:1154-1160.</ref>
	*Can see "vin rose" colored urine from chelated iron extretion		*Can see "vin rose" colored urine from chelated iron extretion
			*[[Cataracts]] with long term use
			*[[Angioedema]]
			*Flushing, urticaria, fever, myalgia, nausea, vomiting

	==Pharmacology==		==Pharmacology==
	*Half-life:		*Half-life: 6h
	*Metabolism:		*Metabolism: Plasma
	*Excretion:		*Excretion: Urine, bile/feces
	*Mechanism of Action:		*Mechanism of Action:

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	==See Also==		==See Also==
			*[[Iron toxicity]]

	==References==		==References==
	<references/>		<references/>
	[[Category:Pharmacology]]		[[Category:Pharmacology]]

Neil.m.young: Text replacement - " pt " to " patient "

2016-07-02T07:38:39Z

Text replacement - " pt " to " patient "

← Older revision		Revision as of 07:38, 2 July 2016
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	===[[Iron toxicity]]===		===[[Iron toxicity]]===
	*1000mg IV; start at 5mg/kg/hr, increase up to 15mg/kg/hr as tolerated for up to 24hrs		*1000mg IV; start at 5mg/kg/hr, increase up to 15mg/kg/hr as tolerated for up to 24hrs
	*Subsequent doses are 500mg increments guided by clinical status of pt / urine color		*Subsequent doses are 500mg increments guided by clinical status of patient / urine color
	*Recommended amount during first 24hr is 360mg/kg not to exceed 6g.		*Recommended amount during first 24hr is 360mg/kg not to exceed 6g.

Ostermayer: Text replacement - "Category:Drugs" to "Category:Pharmacology"

2016-03-22T15:54:04Z

Text replacement - "Category:Drugs" to "Category:Pharmacology"

← Older revision		Revision as of 15:54, 22 March 2016
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	==References==		==References==
	<references/>		<references/>
	[[Category:~~Drugs~~]]		[[Category:Pharmacology]]

Rossdonaldson1: /* Indications */

2015-08-25T14:53:16Z

Indications

← Older revision		Revision as of 14:53, 25 August 2015
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	==Indications==		==Indications==
	*Systemic toxicity and iron level > 350 mcg/dL		{{Deferoxamine indications}}
	*Metabolic acidosis
	*Progressive symptoms
	*Serum iron level >500 mcg/dL

	==Contraindications==		==Contraindications==

Rossdonaldson1: Created page with "==General== Type: Dosage Forms: Routes of Administration: Common Trade Names: ==Adult Dosing== ===Iron toxicity=== *1000mg IV; start at 5mg/kg/hr, increase up to 15..."

2015-08-25T14:30:42Z

Created page with "==General== *Type: *Dosage Forms: *Routes of Administration: *Common Trade Names: ==Adult Dosing== ===Iron toxicity=== *1000mg IV; start at 5mg/kg/hr, increase up to 15..."

New page

==General==
*Type:
*Dosage Forms:
*Routes of Administration:
*Common Trade Names:

==Adult Dosing==
===[[Iron toxicity]]===
*1000mg IV; start at 5mg/kg/hr, increase up to 15mg/kg/hr as tolerated for up to 24hrs
*Subsequent doses are 500mg increments guided by clinical status of pt / urine color
*Recommended amount during first 24hr is 360mg/kg not to exceed 6g.

==Pediatric Dosing==

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]:
*[[Lactation risk categories|Lactation risk]]:
*Renal Dosing
**Adult
**Pediatric
*Hepatic Dosing
**Adult
**Pediatric

==Indications==
*Systemic toxicity and iron level > 350 mcg/dL
*Metabolic acidosis
*Progressive symptoms
*Serum iron level >500 mcg/dL

==Contraindications==
*Allergy to class/drug
*Renal failure patients not on hemodialysis

==Adverse Reactions==
*[[Hypotension]] (pre-existing hypotension is NOT a contraindication to therapy)
*[[ARDS]]
*[[Yersinia enterocolitica]] sepsis<ref>Mazzoleni G. et al. Yersinia enterocolitica infection with ileal perforation associated with iron overload and
deferoxamine therapy. Dig Dis Sci 1991; 36:1154-1160.</ref>
*Can see "vin rose" colored urine from chelated iron extretion

==Pharmacology==
*Half-life:
*Metabolism:
*Excretion:
*Mechanism of Action:

==Comments==
*Chelates iron and creates a water-soluble compound ferrioxamine that is renally excreted and can be dialyzed.<ref name="ironoverview"></ref>

==See Also==

==References==
<references/>
[[Category:Drugs]]