Dexamethasone - Revision history

Danbot: Switch SMW query from broadtable to table format for better layout with TOC

2026-03-20T21:55:46Z

Switch SMW query from broadtable to table format for better layout with TOC

2026-03-20T17:23:48Z

Fix SMW query: replace link=subject with mainlabel=- to fix broken subobject fragment links

2026-03-20T16:41:56Z

Add dynamic SMW Indications by Condition table (auto-populated from disease pages via MedicationDose template)

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 *Excretion: Urine ~10%
 *Mechanism of Action: surpasses neutrophil migration, decreases production of inflammatory mediators, reverses increased capillary permeability, suppresses normal immune response
 ==See Also==

2023-05-19T22:14:20Z

References

← Older revision		Revision as of 22:14, 19 May 2023
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	[[Category:Pharmacology]]		[[Category:Pharmacology]]


	~~Dexamethasone (systemic): Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019.~~

2023-05-19T22:13:49Z

Pediatric Dosing

← Older revision		Revision as of 22:13, 19 May 2023
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	==Pediatric Dosing==		==Pediatric Dosing==
	===[[Anaphylaxis]]===		===[[Anaphylaxis]]===
	*0.~~6mg~~/kg		*0.6 mg/kg
			**Maximum dose of 10-18 mg/dose, variable by study

	===[[Asthma]] Exacerbation===		===[[Asthma]] Exacerbation===
	*0.~~6mg~~/kg once PO		*0.6 mg/kg once PO
			**Maximum dose of 10-18 mg/dose, variable by study

	===Post-operative Airway Edema===		===Post-operative Airway Edema===
	*0.5 mg/kg PO q6hrs x1-2 days		*0.5 mg/kg PO q6hrs x1-2 days
			**Maximum dose of 10-18 mg/dose, variable by study

	==Special Populations==		==Special Populations==

2022-01-05T10:40:55Z

COVID

← Older revision		Revision as of 10:40, 5 January 2022
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	===[[COVID]]===		===[[COVID]]===
	*6mg Qday		*6mg Qday for 10 days
	**Dexamethasone improves 28d mortality compared to placebo in patients requiring IMV (NNT = 8.5) and those patients requiring oxygen therapy (NNT = 29).		**Dexamethasone improves 28d mortality compared to placebo in patients requiring IMV (NNT = 8.5) and those patients requiring oxygen therapy (NNT = 29).
	**There was no benefit to patients not requiring oxygenation support and potentially harm		**There was no benefit to patients not requiring oxygenation support and potentially harm

2021-08-08T21:59:42Z

Adult Dosing

← Older revision		Revision as of 21:59, 8 August 2021
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	===[[Nausea and Vomiting]]===		===[[Nausea and Vomiting]]===
	5mg IV<ref>Wang, Jhi-Joung MD, DMS,; Ho, Shung-Tai MD, MS†,; Uen, Yih-Huei MD‡,; Lin, Mao-Tsun PhD,; Chen, Kuan-Ting MD,; Huang, Jeng-Chai PhD,; Tzeng, Jann-Inn MD Small-Dose Dexamethasone Reduces Nausea and Vomiting After Laparoscopic Cholecystectomy: A Comparison of Tropisetron with Saline, Anesthesia & Analgesia: July 2002 - Volume 95 - Issue 1 - p 229-232 doi: 10.1097/00000539-200207000-00042</ref>		5mg IV<ref>Wang, Jhi-Joung MD, DMS,; Ho, Shung-Tai MD, MS†,; Uen, Yih-Huei MD‡,; Lin, Mao-Tsun PhD,; Chen, Kuan-Ting MD,; Huang, Jeng-Chai PhD,; Tzeng, Jann-Inn MD Small-Dose Dexamethasone Reduces Nausea and Vomiting After Laparoscopic Cholecystectomy: A Comparison of Tropisetron with Saline, Anesthesia & Analgesia: July 2002 - Volume 95 - Issue 1 - p 229-232 doi: 10.1097/00000539-200207000-00042</ref>

			===[[Pharyngitis]]===
			*Single 10mg PO dose decreases symptoms at 48 hours, but not 24 hours<ref>Hayward GN, Hay AD, Moore MV, et al. Effect of Oral Dexamethasone Without Immediate Antibiotics vs Placebo on Acute Sore Throat in Adults: A Randomized Clinical Trial. JAMA. 2017;317(15):1535-1543. doi:10.1001/jama.2017.3417</ref>

	==Pediatric Dosing==		==Pediatric Dosing==

2021-08-08T21:58:43Z

Adult Dosing

← Older revision		Revision as of 21:58, 8 August 2021
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	===[[Nausea and Vomiting]]===		===[[Nausea and Vomiting]]===
	5mg<ref>Wang, Jhi-Joung MD, DMS,; Ho, Shung-Tai MD, MS†,; Uen, Yih-Huei MD‡,; Lin, Mao-Tsun PhD,; Chen, Kuan-Ting MD,; Huang, Jeng-Chai PhD,; Tzeng, Jann-Inn MD Small-Dose Dexamethasone Reduces Nausea and Vomiting After Laparoscopic Cholecystectomy: A Comparison of Tropisetron with Saline, Anesthesia & Analgesia: July 2002 - Volume 95 - Issue 1 - p 229-232 doi: 10.1097/00000539-200207000-00042</ref>		5mg IV<ref>Wang, Jhi-Joung MD, DMS,; Ho, Shung-Tai MD, MS†,; Uen, Yih-Huei MD‡,; Lin, Mao-Tsun PhD,; Chen, Kuan-Ting MD,; Huang, Jeng-Chai PhD,; Tzeng, Jann-Inn MD Small-Dose Dexamethasone Reduces Nausea and Vomiting After Laparoscopic Cholecystectomy: A Comparison of Tropisetron with Saline, Anesthesia & Analgesia: July 2002 - Volume 95 - Issue 1 - p 229-232 doi: 10.1097/00000539-200207000-00042</ref>

	==Pediatric Dosing==		==Pediatric Dosing==

2021-08-08T21:56:52Z

Adult Dosing

← Older revision		Revision as of 21:56, 8 August 2021
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	**Dexamethasone improves 28d mortality compared to placebo in patients requiring IMV (NNT = 8.5) and those patients requiring oxygen therapy (NNT = 29).		**Dexamethasone improves 28d mortality compared to placebo in patients requiring IMV (NNT = 8.5) and those patients requiring oxygen therapy (NNT = 29).
	**There was no benefit to patients not requiring oxygenation support and potentially harm		**There was no benefit to patients not requiring oxygenation support and potentially harm

			===[[Nausea and Vomiting]]===
			5mg<ref>Wang, Jhi-Joung MD, DMS,; Ho, Shung-Tai MD, MS†,; Uen, Yih-Huei MD‡,; Lin, Mao-Tsun PhD,; Chen, Kuan-Ting MD,; Huang, Jeng-Chai PhD,; Tzeng, Jann-Inn MD Small-Dose Dexamethasone Reduces Nausea and Vomiting After Laparoscopic Cholecystectomy: A Comparison of Tropisetron with Saline, Anesthesia & Analgesia: July 2002 - Volume 95 - Issue 1 - p 229-232 doi: 10.1097/00000539-200207000-00042</ref>

	==Pediatric Dosing==		==Pediatric Dosing==

2021-01-16T12:27:36Z

← Older revision		Revision as of 12:27, 16 January 2021
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	===[[Anaphylaxis]]===		===[[Anaphylaxis]]===
	*10mg IV or PO		*10mg IV or PO

			===[[COVID]]===
			*6mg Qday
			**Dexamethasone improves 28d mortality compared to placebo in patients requiring IMV (NNT = 8.5) and those patients requiring oxygen therapy (NNT = 29).
			**There was no benefit to patients not requiring oxygenation support and potentially harm

	==Pediatric Dosing==		==Pediatric Dosing==