Erythema multiforme - Revision history

Rossdonaldson1 at 16:23, 11 December 2024

2024-12-11T16:23:35Z

← Older revision		Revision as of 16:23, 11 December 2024
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	==Background==		==Background==
			{{Skin anatomy background images}}
	*Erythema Multiforme (EM) is an acute, self-limited skin condition		*Erythema Multiforme (EM) is an acute, self-limited skin condition
	*Peak incidence in second and third decades of life		*Peak incidence in second and third decades of life

Elcatracho: /* Background */

2022-01-04T09:11:02Z

Background

← Older revision		Revision as of 09:11, 4 January 2022
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	*Usually self-limited and resolves within 2-6 weeks; may recur		*Usually self-limited and resolves within 2-6 weeks; may recur
	*Wide spectrum of severity		*Wide spectrum of severity
	**Classified as Erythema multiforme minor or Erythema multiforme major		**Classified as Erythema multiforme minor (skin involvement only) or Erythema multiforme major (involves skin and one or more mucous membranes)

	===Precipitants===		===Precipitants===

Elcatracho: /* Evaluation */

2021-02-27T00:46:52Z

Evaluation

← Older revision		Revision as of 00:46, 27 February 2021
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	*Usually made clinically		*Usually made clinically
	*In severe cases, work-up includes basic labs and cultures		*In severe cases, work-up includes basic labs and cultures
	*Punch biopsy: to confirm the diagnosis and to rule out other diagnoses (looks different from SJS/TEN histologically)		*Punch biopsy: to confirm the diagnosis and to rule out other diagnoses (looks different from [[SJS/TEN]] histologically)

	==Management==		==Management==

Elcatracho: /* Precipitants */

2021-02-27T00:46:20Z

Precipitants

← Older revision		Revision as of 00:46, 27 February 2021
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	**Bacterial: [[streptococcus]], [[mycoplasma]], [[tuberculosis]]		**Bacterial: [[streptococcus]], [[mycoplasma]], [[tuberculosis]]
	*Drugs:		*Drugs:
	**Antibiotics ([[penicillin]], sulfonamides), [[anticonvulsants]] ([[phenytoin]], [[barbiturates]]), [[NSAIDS]], [[aspirin]], anti-[[tuberculosis[[ meds, [[allopurinol]], etc.		**Antibiotics ([[penicillin]], sulfonamides), [[anticonvulsants]] ([[phenytoin]], [[barbiturates]]), [[NSAIDS]], [[aspirin]], anti-[[tuberculosis]] meds, [[allopurinol]], etc.
	*Collagen Vascular Disorders:		*Collagen Vascular Disorders:
	**[[RA]], [[SLE]], [[dermatomyositis]], [[polyarteritis nodosa]]		**[[RA]], [[SLE]], [[dermatomyositis]], [[polyarteritis nodosa]]

Elcatracho: /* Background */

2021-02-27T00:45:42Z

Background

← Older revision		Revision as of 00:45, 27 February 2021
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	*Erythema Multiforme (EM) is an acute, self-limited skin condition		*Erythema Multiforme (EM) is an acute, self-limited skin condition
	*Peak incidence in second and third decades of life		*Peak incidence in second and third decades of life
	*Despite multiple associations, thought to be triggered by HSV in most cases		*Despite multiple associations, thought to be triggered by [[HSV]] in most cases
	*Usually self-limited and resolves within 2-6 weeks; may recur		*Usually self-limited and resolves within 2-6 weeks; may recur
	*Wide spectrum of severity		*Wide spectrum of severity

ClaireLewis: /* Management */

2021-02-24T19:44:29Z

Management

← Older revision		Revision as of 19:44, 24 February 2021
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	**Prompt withdrawal of suspected drug/agent causing symptoms		**Prompt withdrawal of suspected drug/agent causing symptoms
	*Symptomatic treatment		*Symptomatic treatment
	**Systemic ~~Corticosteroids~~		**Systemic [[corticosteroids]]
	**Oral [[antihistamines]], [[analgesia\|analgesics]], local skin care		**Oral [[antihistamines]], [[analgesia\|analgesics]], local skin care
	**If oral involvement: soothing mouth washes		**If oral involvement: soothing mouth washes

Cmolson: /* Management */

2021-02-23T12:58:09Z

Management

← Older revision		Revision as of 12:58, 23 February 2021
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	**Prompt withdrawal of suspected drug/agent causing symptoms		**Prompt withdrawal of suspected drug/agent causing symptoms
	*Symptomatic treatment		*Symptomatic treatment
			**Systemic Corticosteroids
	**Oral [[antihistamines]], [[analgesia\|analgesics]], local skin care		**Oral [[antihistamines]], [[analgesia\|analgesics]], local skin care
	**If oral involvement: soothing mouth washes		**If oral involvement: soothing mouth washes
	**If eye involvement: topical lubricants, cleaning of conjunctiva, and removal of fresh adhesions		**If eye involvement: topical lubricants, cleaning of conjunctiva, and removal of fresh adhesions
	**Mild cases with localized lesions, may consider [[topical corticosteroids]]. ~~Use of systemic steroids is controversial~~		**Mild cases with localized lesions, may consider [[topical corticosteroids]].
	*Consultation (rarely) with the following may be necessary: dermatologist, ophthalmologist, burn surgeon		*Consultation (rarely) with the following may be necessary: dermatologist, ophthalmologist, burn surgeon

Rossdonaldson1: /* Differential Diagnosis */

2019-11-27T03:04:58Z

Differential Diagnosis

← Older revision		Revision as of 03:04, 27 November 2019
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	==Differential Diagnosis==		==Differential Diagnosis==
	*Fixed [[drug rash~~\|drug reaction]]~~		{{Erythematous rash DDX}}
	*[[Stevens Johnson Syndrome and Toxic Epidermal Necrolysis]]
	*Subacute cutaneous [[lupus erythematosus]]
	*[[Urticaria]]
	*[[viral illness\|Viral]] exanthems
	*[[allergic reaction\|Allergic]] or irritant [[contact dermatitis]]

	{{Bullous rashes DDX}}		{{Bullous rashes DDX}}

ClaireLewis at 22:27, 27 September 2019

2019-09-27T22:27:30Z

← Older revision		Revision as of 22:27, 27 September 2019
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	**Bacterial: [[streptococcus]], [[mycoplasma]], [[tuberculosis]]		**Bacterial: [[streptococcus]], [[mycoplasma]], [[tuberculosis]]
	*Drugs:		*Drugs:
	**Antibiotics (penicillin, sulfonamides), anticonvulsants (phenytoin, barbiturates), NSAIDS, aspirin, ~~antituberculous~~ meds, allopurinol, etc.		**Antibiotics ([[penicillin]], sulfonamides), [[anticonvulsants]] ([[phenytoin]], [[barbiturates]]), [[NSAIDS]], [[aspirin]], anti-[[tuberculosis[[ meds, [[allopurinol]], etc.
	*Collagen Vascular Disorders:		*Collagen Vascular Disorders:
	**RA, SLE, dermatomyositis, polyarteritis nodosa		**[[RA]], [[SLE]], [[dermatomyositis]], [[polyarteritis nodosa]]
	*Others:		*Others:
	**Pregnancy, cold weather, sunlight, contact exposure, foods, malignancy, hormonal		**[[Pregnancy]], cold weather, sunlight, contact exposure, foods, malignancy, hormonal

	==Clinical Features==		==Clinical Features==
	[[File:EM_picture.jpeg\|thumb\|Erythema Multiforme]]		[[File:EM_picture.jpeg\|thumb\|Erythema Multiforme]]
	[[File:Erythema multiforme minor of the hand.jpg\|thumb\|Erythema multiforme minor of the hand (note of make of the blanching centers of the lesion)]]		[[File:Erythema multiforme minor of the hand.jpg\|thumb\|Erythema multiforme minor of the hand (note of make of the blanching centers of the lesion)]]
	*Erythematous or violaceous macules, papules, vesicles, or bullae		*Erythematous or violaceous [[rash\|macules, papules, vesicles, or bullae]]
	*Target lesions with “three zones of color” are the hallmark of EM		*Target lesions with “three zones of color” are the hallmark of EM
	*Distribution is usually symmetric, most commonly involving palms/soles, the backs of the hands/feet, and/or the extensor surfaces of the extremities		*Distribution is usually symmetric, most commonly involving palms/soles, the backs of the hands/feet, and/or the extensor surfaces of the extremities
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	==Differential Diagnosis==		==Differential Diagnosis==
	*Fixed drug reaction		*Fixed [[drug rash\|drug reaction]]
	*[[Stevens Johnson Syndrome and Toxic Epidermal Necrolysis]]		*[[Stevens Johnson Syndrome and Toxic Epidermal Necrolysis]]
	*Subacute cutaneous lupus erythematosus		*Subacute cutaneous [[lupus erythematosus]]
	*[[Urticaria]]		*[[Urticaria]]
	*Viral exanthems		*[[viral illness\|Viral]] exanthems
	*Allergic or irritant contact dermatitis		*[[allergic reaction\|Allergic]] or irritant [[contact dermatitis]]

	{{Bullous rashes DDX}}		{{Bullous rashes DDX}}
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	**Prompt withdrawal of suspected drug/agent causing symptoms		**Prompt withdrawal of suspected drug/agent causing symptoms
	*Symptomatic treatment		*Symptomatic treatment
	**Oral antihistamines, analgesics, local skin care		**Oral [[antihistamines]], [[analgesia\|analgesics]], local skin care
	**If oral involvement: soothing mouth washes		**If oral involvement: soothing mouth washes
	**If eye involvement: topical lubricants, cleaning of conjunctiva, and removal of fresh adhesions		**If eye involvement: topical lubricants, cleaning of conjunctiva, and removal of fresh adhesions
	**Mild cases with localized lesions, may consider topical corticosteroids. Use of systemic steroids is controversial		**Mild cases with localized lesions, may consider [[topical corticosteroids]]. Use of systemic steroids is controversial
	*Consultation (rarely) with the following may be necessary: dermatologist, ophthalmologist, burn surgeon		*Consultation (rarely) with the following may be necessary: dermatologist, ophthalmologist, burn surgeon

Lisayee25: /* Clinical Features */

2018-02-10T02:22:26Z

Clinical Features

← Older revision		Revision as of 02:22, 10 February 2018
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	*Target lesions with “three zones of color” are the hallmark of EM		*Target lesions with “three zones of color” are the hallmark of EM
	*Distribution is usually symmetric, most commonly involving palms/soles, the backs of the hands/feet, and/or the extensor surfaces of the extremities		*Distribution is usually symmetric, most commonly involving palms/soles, the backs of the hands/feet, and/or the extensor surfaces of the extremities
	*Not to be confused with SJS/TEN, which are now considered separate from the EM spectrum		*Not to be confused with [[SJS\|SJS/TEN]], which are now considered separate from the EM spectrum

	===Erythema multiforme minor===		===Erythema multiforme minor===