https://wikem.org/w/index.php?action=history&feed=atom&title=Ethacrynic_acid 2026-04-21T05:41:47Z Revision history for this page on the wiki MediaWiki 1.38.2 https://wikem.org/w/index.php?title=Ethacrynic_acid&diff=118861&oldid=prev 2017-01-15T21:05:15Z

<p>Created page with &quot;==Administration== *Type: Loop <a href="/wiki/Diuretic" class="mw-redirect" title="Diuretic">diuretic</a> *Dosage Forms: *Routes of Administration: PO, IV (ethacrynate sodium) *Common Trade Names: Edecrin ==Adult Dosing== &#039;&#039;40mg furos...&quot;</p> <p><b>New page</b></p><div>==Administration==<br /> *Type: Loop [[diuretic]]<br /> *Dosage Forms:<br /> *Routes of Administration: PO, IV (ethacrynate sodium)<br /> *Common Trade Names: Edecrin<br /> <br /> ==Adult Dosing==<br /> ''40mg [[furosemide]] = 20mg [[torsemide]] = 1mg [[bumetanide]] = 50 mg [[ethacrynic acid]]''<br /> *Ethacrynic acid: 50 to 200 PO daily, adjust dose in 25mg increments<br /> *Ethacrynate sodium: 0.5 to 1 mg/kg IV, max 100mg per dose; average dose 50 mg. <br /> <br /> ==Pediatric Dosing==<br /> *Contraindicated in infants, safety/efficacy not well established in children<br /> *Ethacrynic acid: 25 mg PO daily initially, titrate in 25mg increments. Max dose 3 mg/kg/day<br /> *Ethacrynate sodium: dose not well established, titrate carefully<br /> <br /> ==Special Populations==<br /> *[[Drug pregnancy categories|Pregnancy Rating]]: B<br /> *Lactation risk: Infant risk cannot be ruled out<br /> *Renal dosing: avoid use if GFR &lt;10<br /> *Hepatic dosing: use smallest dose necessary to achieve adequate diuresis<br /> <br /> ==Contraindications==<br /> *Allergy to class/drug<br /> *Anuria<br /> *Severe renal disease: if worsening electrolyte imbalance, azotemia, or oliguria develops discontinue and do not reinitiate<br /> *If severe, watery diarrhea occurs, discontinue and do not reinitiate <br /> *Infants<br /> <br /> ==Adverse Reactions==<br /> ===Serious===<br /> *Electrolyte imbalances, hypocalcemia, hypokalemia, hyponatremia<br /> *GI bleed, GI perforation, diarrhea, pancreatitis<br /> *Agranulocytosis/neutropenia, thrombocytopenia<br /> *Thromboembolic disorder<br /> *Hepatic coma, jaundice<br /> *Ototoxicity, hearing loss<br /> ===Common===<br /> <br /> ==Pharmacology==<br /> *Half-life: 1-4h<br /> *Metabolism: Liver<br /> *Excretion: Mostly renal<br /> <br /> ==Mechanism of Action==<br /> *Loop diuretic: inhibits Na+/K+/2Cl symporter in ascending limb of loop of Henle, preventing reabsorption and thereby increasing urinary excretion of sodium, chloride, and potassium<br /> <br /> ==Comments==<br /> <br /> <br /> ==See Also==<br /> *[[Diuretics]]<br /> <br /> ==References==<br /> &lt;references/&gt;<br /> <br /> [[Category:Pharmacology]]</div>

ClaireLewis