Ethosuximide - Revision history

Elcatracho: /* See Also */

2021-03-08T15:43:49Z

ClaireLewis: /* References */

2019-09-22T19:35:27Z

References

← Older revision		Revision as of 19:35, 22 September 2019
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	[[Category:Pharmacology]]		[[Category:Pharmacology]]
			[[Category:Neurology]]

Mholtz: Text replacement - "qd" to "QD"

2017-07-07T09:00:37Z

Text replacement - "qd" to "QD"

← Older revision		Revision as of 09:00, 7 July 2017
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	*3-6 yo		*3-6 yo
	**20 mg/kg/day PO divided bid		**20 mg/kg/day PO divided bid
	***Start: 250 mg PO qd		***Start: 250 mg PO QD
	***Max: 1.5 g/day		***Max: 1.5 g/day
	***Taper dose based on tx response to D/C		***Taper dose based on tx response to D/C
	*6+ yo		*6+ yo
	**20 mg/kg/day PO divided bid		**20 mg/kg/day PO divided bid
	***Start: 250 mg PO qd		***Start: 250 mg PO QD
	***Max: 1.5 g/day		***Max: 1.5 g/day
	***Taper dose based on tx response to D/C		***Taper dose based on tx response to D/C

Jonwarren: Creation of Page

2017-05-18T20:45:48Z

Creation of Page

New page

==Administration==
*Type: [[Anticonvulsant]]
*Dosage Forms: 250; 250/5mL
*Routes of Administration: oral tablet, oral syrup
*Common Trade Names: Zarontin

==Adult Dosing==
===[[Seizure]], absence===
*Start: 250mg PO bid
**May increase 250mg/day q4-7 days
**Taper dose based on tx response to D/C
*Max: 1.5 g/day

==Pediatric Dosing==
===[[Seizure]], absence===
*3-6 yo
**20 mg/kg/day PO divided bid
***Start: 250 mg PO qd
***Max: 1.5 g/day
***Taper dose based on tx response to D/C
*6+ yo
**20 mg/kg/day PO divided bid
***Start: 250 mg PO qd
***Max: 1.5 g/day
***Taper dose based on tx response to D/C

==Special Populations==
*[[Drug pregnancy categories|Pregnancy Rating]]: C
*Lactation risk: L3
===Renal Dosing===
*Adult:
**CrCl <10: Decrease dose 25%
**HD: Give after dialysis
**PD: No adjustment
*Pediatric:
**CrCl <10: Decrease dose 25%
**HD: Give after dialysis
**PD: No adjustment

===Hepatic Dosing===
*Adult: Not defined
*Pediatric: Not defined

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===
*[[Agranulocytosis]]
*[[Pancytopenia]]
*[[Leukopenia]]
*Blood dyscrasias
*[[Lupus]] erythematosus
*Aggressive behavior
*Suicidality
*[[Depression]]
*Paranoid psychosis
*[[Stevens-Johnson syndrome]]
*Hypersensitivity reaction
*Withdrawal seizures if abrupt D/C

===Common===
*Anorexia
*[[Dyspepsia]]
*[[Nausea]]/[[Vomiting]]
*[[Abdominal pain]]
*Weight loss
*[[Diarrhea]]
*Drowsiness
*[[Headache]]
*[[Dizziness]]
*Euphoria
*Hiccups
*Irritability
*Hyperactivity
*[[Ataxia]]
*Sleep disturbance
*Impaired concentration
*[[Rash]]
*Pruritus
*Hirsutism

==Pharmacology==
*Half-life: 56-60 hr
*Metabolism: Liver extensively; CYP450: 3A4 substrate
*Excretion: Urine primarily (<20% unchanged), bile/feces

==Mechanism of Action==
*Depresses motor cortex
*Elevates CNS convulsive stimuli threshold

==Comments==

==See Also==
*[[Seizure]]
*[[Anticonvulsants]]

==References==
<references/>

[[Category:Pharmacology]]

← Older revision		Revision as of 15:43, 8 March 2021
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	*[[Seizure]]		*[[Seizure]]
	*[[Anticonvulsants]]		*[[Anticonvulsants]]
			*[[Anticonvulsant levels and reloading]]

	==References==		==References==