Glucose-6-phosphate deficiency - Revision history

Elcatracho: /* Workup */

2021-01-06T19:24:42Z

Workup

← Older revision		Revision as of 19:24, 6 January 2021
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	===Workup===		===Workup===
	*CBC		*CBC
	**Heinz Bodies		**Heinz Bodies and Bite Cells on peripheral smear
	*Retic Count		*Retic Count
	**Retic count high		**Retic count high

Rossdonaldson1: /* Clinical Features */

2020-06-04T18:42:47Z

Clinical Features

← Older revision		Revision as of 18:42, 4 June 2020
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	==Clinical Features==		==Clinical Features==
			[[File:Jaundice.jpg\|thumb\|Pediatric jaundice with icterus of sclera.]]
	*[[Hemolytic anemia]]		*[[Hemolytic anemia]]
	*[[Fatigue]]		*[[Fatigue]]
	*[[Jaundice]]		*[[Jaundice]]
	*[[Splenomegaly]]		*Splenomegaly

	==Complications==		==Complications==

Rossdonaldson1: /* Background */

2020-06-04T18:41:51Z

Background

← Older revision		Revision as of 18:41, 4 June 2020
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	==Background==		==Background==
			[[File:Pathology of G6PD deficiency 2.png\|thumb\|G6PD pathway]]
	*Abbreviation: G6PD		*Abbreviation: G6PD
	*X-Linked recessive; protects against [[Malaria]]		*X-Linked recessive; protects against [[Malaria]]

ClaireLewis at 00:32, 1 October 2019

2019-10-01T00:32:52Z

← Older revision		Revision as of 00:32, 1 October 2019
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	*Mild form exists, which predominantly affects men of African decent. It is typically self-limited because it affects older RBCs (with less G6PD left)		*Mild form exists, which predominantly affects men of African decent. It is typically self-limited because it affects older RBCs (with less G6PD left)
	*More severe form occurs predominantly in men of Mediterranean descent (specifically Greeks and Italians). Causes a more severe hemolytic anemia because RBCs of any age are involved		*More severe form occurs predominantly in men of Mediterranean descent (specifically Greeks and Italians). Causes a more severe hemolytic anemia because RBCs of any age are involved
	*Nonimmune mediated hemolytic anemia		*Nonimmune mediated [[hemolytic anemia]]
	*Stress or drugs can cause hemoglobin precipitation within the RBC		*Stress or drugs can cause hemoglobin precipitation within the RBC
	**Leads to removal of the cell from circulation via the spleen		**Leads to removal of the cell from circulation via the spleen

	===Precipitants===		===Precipitants===
	*Infection		*[[Infection]]
	*Fava beans		*Fava beans
	*Medications		*Medications
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	**[[Dapsone]]		**[[Dapsone]]
	**[[Chloramphenicol]]		**[[Chloramphenicol]]
	**Antimalarials (e.g. [[quinine]], [[mefloquine]])		**[[Antimalarials]] (e.g. [[quinine]], [[mefloquine]])
	**[[Sulfonamides]]		**[[Sulfonamides]]
	**[[Ciprofloxacin]], norfloxacin		**[[Ciprofloxacin]], norfloxacin
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	==Clinical Features==		==Clinical Features==
	*~~Fatigue~~		*[[Hemolytic anemia]]
	*~~Hemolytic anemia~~		*[[Fatigue]]
	*[[Jaundice]]		*[[Jaundice]]
	*[[Splenomegaly]]		*[[Splenomegaly]]

			==Complications==
			*Severe hemolysis and [[anemia]]
			*[[shock\|Cardiovascular collapse]]

	==Differential Diagnosis==		==Differential Diagnosis==
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	==Management<ref>Schick P et al. eMedicine. Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency Treatment & Management. Sep 29, 2015. http://emedicine.medscape.com/article/200390-treatment#showall</ref>==		==Management<ref>Schick P et al. eMedicine. Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency Treatment & Management. Sep 29, 2015. http://emedicine.medscape.com/article/200390-treatment#showall</ref>==
	*Identify and discontinue precipitating agent		*Identify and discontinue precipitating agent
	*Supportive care for anemia, with transfusions rarely needed		*Supportive care for anemia, with [[pRBCs\|transfusions]] rarely needed
	*Hemolysis usually self-limited, resolving within 8-14 days		*Hemolysis usually self-limited, resolving within 8-14 days
	*Infants		*Infants
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	===Alternative Antibiotics===		===Alternative Antibiotics===
	*Cephalexin (Keflex)		*[[Cephalexin]] (Keflex)

	==Disposition==		==Disposition==

	~~==Complications==~~
	*Severe hemolysis and anemia
	*Cardiovascular collapse

	==Also See==		==Also See==

ClaireLewis: /* ManagementSchick P et al. eMedicine. Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency Treatment & Management. Sep 29, 2015. http://emedicine.medscape.com/article/200390-treatment#showall */

2017-04-03T18:03:21Z

ManagementSchick P et al. eMedicine. Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency Treatment & Management. Sep 29, 2015. http://emedicine.medscape.com/article/200390-treatment#showall

← Older revision		Revision as of 18:03, 3 April 2017
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	*Infants		*Infants
	**Prolonged neonatal jaundice due to G6PD deficiency may require phototherapy		**Prolonged neonatal jaundice due to G6PD deficiency may require phototherapy
	**Exchange transfusion for severe neonatal jaundice		**[[Exchange transfusion]] for severe neonatal jaundice

	===Alternative Antibiotics===		===Alternative Antibiotics===

ClaireLewis: /* Precipitants */

2016-10-19T15:27:45Z

Precipitants

← Older revision		Revision as of 15:27, 19 October 2016
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	===Precipitants===		===Precipitants===
	*Infection		*Infection
	*Fava ~~Beans~~		*Fava beans
	*Medications		*Medications
	**[[Nitrofurantoin]]		**[[Nitrofurantoin]]
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	**[[Dapsone]]		**[[Dapsone]]
	**[[Chloramphenicol]]		**[[Chloramphenicol]]
	**Antimalarials (e.g. [[quinine]], [[mefloquine]]		**Antimalarials (e.g. [[quinine]], [[mefloquine]])
	**[[Sulfonamides]]		**[[Sulfonamides]]
	**[[Ciprofloxacin]], norfloxacin		**[[Ciprofloxacin]], norfloxacin

ClaireLewis: /* Precipitants */

2016-10-19T15:27:26Z

Precipitants

← Older revision		Revision as of 15:27, 19 October 2016
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	**[[Dapsone]]		**[[Dapsone]]
	**[[Chloramphenicol]]		**[[Chloramphenicol]]
	**[[~~Antimalarials~~]]		**Antimalarials (e.g. [[quinine]], [[mefloquine]]
	**[[Sulfonamides]]		**[[Sulfonamides]]
	**[[Ciprofloxacin]], norfloxacin		**[[Ciprofloxacin]], norfloxacin
	**Methylene blue		**[[Methylene blue]]
	**Vitamin K analogues		**Vitamin K analogues (e.g. [[warfarin]])

	==Clinical Features==		==Clinical Features==

Rossdonaldson1: Rossdonaldson1 moved page Glucose-6-Phosphate Deficiency (G6PD) to Glucose-6-phosphate deficiency

2016-09-02T14:48:46Z

Rossdonaldson1 moved page Glucose-6-Phosphate Deficiency (G6PD) to Glucose-6-phosphate deficiency

← Older revision	Revision as of 14:48, 2 September 2016
(No difference)

Rossdonaldson1: /* Background */

2016-09-02T14:48:30Z

Background

← Older revision		Revision as of 14:48, 2 September 2016
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	==Background==		==Background==
			*Abbreviation: G6PD
	*X-Linked recessive; protects against [[Malaria]]		*X-Linked recessive; protects against [[Malaria]]
	*Mild form exists, which predominantly affects men of African decent. It is typically self-limited because it affects older RBCs (with less G6PD left)		*Mild form exists, which predominantly affects men of African decent. It is typically self-limited because it affects older RBCs (with less G6PD left)

AnthonyLucero: added some bullet points in the background section

2016-09-02T04:26:50Z

added some bullet points in the background section

← Older revision		Revision as of 04:26, 2 September 2016
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	==Background==		==Background==
	*X-Linked recessive; protects against [[Malaria]]		*X-Linked recessive; protects against [[Malaria]]
	*African~~, Asian, and~~ Mediterranean descent		*Mild form exists, which predominantly affects men of African decent. It is typically self-limited because it affects older RBCs (with less G6PD left)
			*More severe form occurs predominantly in men of Mediterranean descent (specifically Greeks and Italians). Causes a more severe hemolytic anemia because RBCs of any age are involved
	*Nonimmune mediated hemolytic anemia		*Nonimmune mediated hemolytic anemia
	*Stress or drugs can cause hemoglobin precipitation within the RBC		*Stress or drugs can cause hemoglobin precipitation within the RBC