Goodpasture syndrome - Revision history

Kfarzam: /* Clinical Features */

2022-08-18T17:45:18Z

Clinical Features

← Older revision		Revision as of 17:45, 18 August 2022
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	*Renal: [[glomerulonephritis]]		*Renal: [[glomerulonephritis]]
	**[[Hematuria]], [[proteinuria]], RBC casts		**[[Hematuria]], [[proteinuria]], RBC casts
			*Symptoms are often rapidly progressive

	==Differential Diagnosis==		==Differential Diagnosis==

ClaireLewis: /* Evaluation */

2019-10-12T16:02:04Z

Evaluation

← Older revision		Revision as of 16:02, 12 October 2019
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	==Evaluation==		==Evaluation==
	*Pulmonary		*Pulmonary
	**Depends whether patient stable or not, massive [[hemoptysis or not]]		**Depends whether patient stable or not, massive [[hemoptysis]] or not
	**Consider: [[CXR]] vs CT chest w/contrast, CBC, coags, T&S, bronchoscopy		**Consider: [[CXR]] vs CT chest w/contrast, CBC, coags, T&S, bronchoscopy
	*Renal:		*Renal:

ClaireLewis at 15:50, 12 October 2019

2019-10-12T15:50:50Z

← Older revision		Revision as of 15:50, 12 October 2019
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	==Background==		==Background==
	*Goodpasture syndrome (60%): diffuse ~~pulmonary~~ hemorrhage + acute glomerulonephritis		*Goodpasture syndrome (60%): [[diffuse alveolar hemorrhage]] + acute [[glomerulonephritis]]
	*Goodpasture disease: glomerulonephritis alone (30%,) pulmonary symptoms alone (10%,)		*Goodpasture disease: [[glomerulonephritis]] alone (30%,) pulmonary symptoms alone (10%,)
	*Anti-GBM disease is most precise term for both entities		*Anti-GBM disease is most precise term for both entities
	**Type II ~~hypersensitivty~~ causing linear IG deposition in glomerular and alveolar BM		**Type II hypersensitivity causing linear IG deposition in glomerular and alveolar BM
	**Triggered by:		**Triggered by:
	***Sepsis		***[[Sepsis]]
	***URI		***[[URI]]
	***Inhalation injury		***[[Inhalation injury]]
	***Smoking		***Smoking
	***Pulmonary edema		***[[Pulmonary edema]]

	==Clinical Features==		==Clinical Features==
	*Constitutional symptoms prior to pulmonary/renal complications		*Constitutional symptoms prior to pulmonary/renal complications
	*Pulmonary		*Pulmonary
	**Cough, dyspnea, chest pain, hemoptysis, respiratory failure or pulmonary hemorrhage		**[[Cough]], [[dyspnea]], [[chest pain]], [[hemoptysis]], [[respiratory failure]] or [[diffuse alveolar hemorrhage\|pulmonary hemorrhage]]
	*Renal		*Renal: [[glomerulonephritis]]
	**~~See~~ [[~~Glomerulonephritis~~]]		**[[Hematuria]], [[proteinuria]], RBC casts

	==Differential Diagnosis==		==Differential Diagnosis==
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	==Evaluation==		==Evaluation==
	*Pulmonary		*Pulmonary
	**Depends whether patient stable or not		**Depends whether patient stable or not, massive [[hemoptysis or not]]
	**~~See~~ [[~~hemoptysis~~]]		**Consider: [[CXR]] vs CT chest w/contrast, CBC, coags, T&S, bronchoscopy
	*Renal:		*Renal:
	*[[Urinalysis]], CBC, Chemistry, Albumin (often reduced in acute glomerulonephritis,) C3, C4, ASO, ANCA		**[[Urinalysis]], CBC, Chemistry, Albumin (often reduced in acute glomerulonephritis,) C3, C4, ASO, ANCA

	==Management==		==Management==
	*See [[Hemoptysis]]		*See [[Hemoptysis]]
	*See [[Glomerulonephritis]]		**Massive: intubate (ideally ETT >8.0), angio or bronch to identify and stop localized source, consider nebulized [[TXA]]
			**Correct [[coagulopathy]]
			**[[Methylprednisolone]] 1g + [[plasmapheresis]]
			*See [[Glomerulonephritis]], consult nephrology
	*[[Plasmapheresis]] shown to be beneficial <ref> Levy JB, Turner AN, Rees AJ, Pusey CD. Long-term outcome of anti-glomerular basement membrane antibody disease treated with plasma exchange and immunosuppression. Ann Intern Med. 2001 Jun 5. 134(11):1033-42 </ref>		*[[Plasmapheresis]] shown to be beneficial <ref> Levy JB, Turner AN, Rees AJ, Pusey CD. Long-term outcome of anti-glomerular basement membrane antibody disease treated with plasma exchange and immunosuppression. Ann Intern Med. 2001 Jun 5. 134(11):1033-42 </ref>
	*In severe cases may need:		*In severe cases may need:

Kxl328: /* Background */

2018-10-14T17:47:42Z

Background

← Older revision		Revision as of 17:47, 14 October 2018
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	==Background==		==Background==
	*Goodpasture syndrome (60%): diffuse pulmonary hemorrhage + acute glomerulonephritis.		*Goodpasture syndrome (60%): diffuse pulmonary hemorrhage + acute glomerulonephritis
	*Goodpasture disease: glomerulonephritis alone (30%,) pulmonary symptoms alone (10%,)		*Goodpasture disease: glomerulonephritis alone (30%,) pulmonary symptoms alone (10%,)
	*Anti-GBM disease is most precise term for both entities.		*Anti-GBM disease is most precise term for both entities
	**Type II hypersensitivty causing linear IG deposition in glomerular and alveolar BM.		**Type II hypersensitivty causing linear IG deposition in glomerular and alveolar BM
	**Triggered by:Sepsis, URI~~, inhalation~~ injury~~, smoking, pulmonary~~ edema.		**Triggered by:
			***Sepsis
			***URI
			***Inhalation injury
			***Smoking
			***Pulmonary edema

	==Clinical Features==		==Clinical Features==

ClaireLewis: /* Management */

2017-04-03T17:55:03Z

Management

← Older revision		Revision as of 17:55, 3 April 2017
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	*See [[Hemoptysis]]		*See [[Hemoptysis]]
	*See [[Glomerulonephritis]]		*See [[Glomerulonephritis]]
	*~~Plasmapharesis~~ shown to be beneficial <ref> Levy JB, Turner AN, Rees AJ, Pusey CD. Long-term outcome of anti-glomerular basement membrane antibody disease treated with plasma exchange and immunosuppression. Ann Intern Med. 2001 Jun 5. 134(11):1033-42 </ref>		*[[Plasmapheresis]] shown to be beneficial <ref> Levy JB, Turner AN, Rees AJ, Pusey CD. Long-term outcome of anti-glomerular basement membrane antibody disease treated with plasma exchange and immunosuppression. Ann Intern Med. 2001 Jun 5. 134(11):1033-42 </ref>
	*In severe cases may need:		*In severe cases may need:
	**Rheumatology eval: Immunosuppressants		**Rheumatology eval: Immunosuppressants

Rossdonaldson1: Text replacement - "UA" to "Urinalysis"

2016-10-02T15:56:07Z

Text replacement - "*UA" to "*Urinalysis"

← Older revision		Revision as of 15:56, 2 October 2016
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	**See [[hemoptysis]]		**See [[hemoptysis]]
	*Renal:		*Renal:
	*UA, CBC, Chemistry, Albumin (often reduced in acute glomerulonephritis,) C3, C4, ASO, ANCA		*[[Urinalysis]], CBC, Chemistry, Albumin (often reduced in acute glomerulonephritis,) C3, C4, ASO, ANCA

	==Management==		==Management==

Neil.m.young: Text replacement - "==Diagnosis==" to "==Evaluation=="

2016-07-22T05:56:40Z

Text replacement - "==Diagnosis==" to "==Evaluation=="

← Older revision		Revision as of 05:56, 22 July 2016
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	{{Glomerulonephritis causes}}		{{Glomerulonephritis causes}}

	==~~Diagnosis~~==		==Evaluation==
	*Pulmonary		*Pulmonary
	**Depends whether patient stable or not		**Depends whether patient stable or not

Neil.m.young: Text replacement - "sx " to "symptoms "

2016-07-09T15:10:17Z

Text replacement - "sx " to "symptoms "

← Older revision		Revision as of 15:10, 9 July 2016
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	==Background==		==Background==
	*Goodpasture syndrome (60%): diffuse pulmonary hemorrhage + acute glomerulonephritis.		*Goodpasture syndrome (60%): diffuse pulmonary hemorrhage + acute glomerulonephritis.
	*Goodpasture disease: glomerulonephritis alone (30%,) pulmonary sx alone (10%,)		*Goodpasture disease: glomerulonephritis alone (30%,) pulmonary symptoms alone (10%,)
	*Anti-GBM disease is most precise term for both entities.		*Anti-GBM disease is most precise term for both entities.
	**Type II hypersensitivty causing linear IG deposition in glomerular and alveolar BM.		**Type II hypersensitivty causing linear IG deposition in glomerular and alveolar BM.

Neil.m.young: Text replacement - " pt " to " patient "

2016-07-01T21:24:01Z

Text replacement - " pt " to " patient "

← Older revision		Revision as of 21:24, 1 July 2016
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	==Diagnosis==		==Diagnosis==
	*Pulmonary		*Pulmonary
	**Depends whether pt stable or not		**Depends whether patient stable or not
	**See [[hemoptysis]]		**See [[hemoptysis]]
	*Renal:		*Renal:

Ostermayer: Text replacement - "Category:Pulm" to "Category:Pulmonary"

2016-03-22T16:11:34Z

Text replacement - "Category:Pulm" to "Category:Pulmonary"

← Older revision		Revision as of 16:11, 22 March 2016
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	<references/>		<references/>

	[[Category:~~Pulm~~]]		[[Category:Pulmonary]]
	[[Category:Renal]]		[[Category:Renal]]