Imipenem/Cilastatin - Revision history

Danbot: Remove disease-specific entries now covered by AntibioticDose (2 sections)

2026-03-20T11:07:55Z

Remove disease-specific entries now covered by AntibioticDose (2 sections)

← Older revision		Revision as of 11:07, 20 March 2026
Line 9:		Line 9:
	*Moderately-susceptible organisms: 1g IV q6-8 hours		*Moderately-susceptible organisms: 1g IV q6-8 hours
	*Max: Lower of 50mg/kg or 4 g/day		*Max: Lower of 50mg/kg or 4 g/day
	~~===[[Anthrax]], systemic===~~
	*1g IV q6h for at least 2wk


Line 30:		Line 28:
	*First Dose: 10-16.6mg/kg IV x 1		*First Dose: 10-16.6mg/kg IV x 1
	*Max: 4000mg/day		*Max: 4000mg/day
	~~===[[Anthrax]], systemic===~~
	*Neonates >32 wk gestation
	**40-75 mg/kg/day IV divided q8-12h for at least 2wk
	*1 month and older
	**100 mg/kg/day IV divided q6h for at least 2wk

Danbot: Remove disease-specific dosing covered by dynamic SMW tables

2026-03-20T02:57:24Z

Remove disease-specific dosing covered by dynamic SMW tables

← Older revision		Revision as of 02:57, 20 March 2026
Line 9:		Line 9:
	*Moderately-susceptible organisms: 1g IV q6-8 hours		*Moderately-susceptible organisms: 1g IV q6-8 hours
	*Max: Lower of 50mg/kg or 4 g/day		*Max: Lower of 50mg/kg or 4 g/day
	~~===UTI===~~
	*500mg IV q6h
	~~===[[Pneumonia]], hospital acquired===~~
	*500mg IV q6h x7 days
	===[[Anthrax]], systemic===		===[[Anthrax]], systemic===
	*1g IV q6h for at least 2wk		*1g IV q6h for at least 2wk

Danbot: Restore original dosing content alongside dynamic SMW tables

2026-03-20T02:38:16Z

Restore original dosing content alongside dynamic SMW tables

← Older revision		Revision as of 02:38, 20 March 2026
Line 5:		Line 5:

	==Adult Dosing==		==Adult Dosing==
			===General===
			*Fully-susceptible organisms: 500mg IV q6 hours
			*Moderately-susceptible organisms: 1g IV q6-8 hours
			*Max: Lower of 50mg/kg or 4 g/day
			===UTI===
			*500mg IV q6h
			===[[Pneumonia]], hospital acquired===
			*500mg IV q6h x7 days
			===[[Anthrax]], systemic===
			*1g IV q6h for at least 2wk


	===Indications by Disease===		===Indications by Disease===
	{{#ask: [[Has DrugName::Imipenem/Cilastatin]] [[Has Population::Adult]]		{{#ask: [[Has DrugName::Imipenem/Cilastatin]] [[Has Population::Adult]]
	\|?Treats disease=Disease		\|?Treats disease=Disease
	\|?Has Dose=Dose		\|?Has Dose=Dose
	\|?Has Context=Context		\|?Has Context=Context
	\|format=table		\|format=table
	\|limit=50		\|limit=50
	\|mainlabel=-		\|mainlabel=-
	\|headers=show		\|headers=show
	\|sort=Treats disease		\|sort=Treats disease
	}}		}}

	==Pediatric Dosing==		==Pediatric Dosing==
			===General<ref>Red Book, 2012</ref>===
			*60-100mg/kg/day IV divided q6 hours
			*First Dose: 10-16.6mg/kg IV x 1
			*Max: 4000mg/day
			===[[Anthrax]], systemic===
			*Neonates >32 wk gestation
			**40-75 mg/kg/day IV divided q8-12h for at least 2wk
			*1 month and older
			**100 mg/kg/day IV divided q6h for at least 2wk


	===Indications by Disease===		===Indications by Disease===
	{{#ask: [[Has DrugName::Imipenem/Cilastatin]] [[Has Population::Pediatric]]		{{#ask: [[Has DrugName::Imipenem/Cilastatin]] [[Has Population::Pediatric]]
	\|?Treats disease=Disease		\|?Treats disease=Disease
	\|?Has Dose=Dose		\|?Has Dose=Dose
	\|?Has Context=Context		\|?Has Context=Context
	\|format=table		\|format=table
	\|limit=50		\|limit=50
	\|mainlabel=-		\|mainlabel=-
	\|headers=show		\|headers=show
	\|sort=Treats disease		\|sort=Treats disease
	}}		}}

Danbot: Replace manual dosing with dynamic SMW tables (Adult + Pediatric)

2026-03-20T01:52:01Z

Replace manual dosing with dynamic SMW tables (Adult + Pediatric)

← Older revision		Revision as of 01:52, 20 March 2026
Line 5:		Line 5:

	==Adult Dosing==		==Adult Dosing==
	===~~General~~===		===Indications by Disease===
	*Fully-susceptible organisms: ~~500mg IV q6 hours~~		{{#ask: [[Has DrugName::Imipenem/Cilastatin]] [[Has Population::Adult]]
	*Moderately-susceptible organisms: ~~1g IV q6-8 hours~~		\|?Treats disease=Disease
	*Max: ~~Lower of 50mg~~/~~kg or 4 g/day~~		\|?Has Dose=Dose
	~~===UTI===~~		\|?Has Context=Context
	*500mg IV q6h		\|format=table
	~~===~~[[~~Pneumonia~~]]~~, hospital acquired~~===		\|limit=50
	*500mg IV q6h x7 days		\|mainlabel=-
	===~~[[Anthrax]], systemic==~~=		\|headers=show
	*1g IV q6h for at least 2wk		\|sort=Treats disease
			}}

	==Pediatric Dosing==		==Pediatric Dosing==
	===~~General<ref>Red Book, 2012</ref>~~===		===Indications by Disease===
	*60-100mg/kg/day IV divided q6 hours		{{#ask: [[Has DrugName::Imipenem/Cilastatin]] [[Has Population::Pediatric]]
	*First Dose: ~~10-16.6mg/kg IV x 1~~		\|?Treats disease=Disease
	*Max: ~~4000mg~~/~~day~~		\|?Has Dose=Dose
	~~===~~[[~~Anthrax~~]]~~, systemic~~===		\|?Has Context=Context
	*Neonates >32 wk gestation		\|format=table
	**40-~~75 mg/kg/day IV divided q8-12h for at least 2wk~~		\|limit=50
	*1 month and older		\|mainlabel=-
	**100 mg/kg/day IV divided q6h for at least 2wk		\|headers=show
			\|sort=Treats disease
			}}

	==Special Populations==		==Special Populations==

Ostermayer at 19:22, 19 July 2025

2025-07-19T19:22:27Z

← Older revision		Revision as of 19:22, 19 July 2025
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	\| \|\|[[Klebsiella]] sp\|\|'''S'''		\| \|\|[[Klebsiella]] sp\|\|'''S'''
	\|-		\|-
	\| \|\|E. coli/Klebsiella ESBL+\|\|'''S'''		\| \|\|E. coli/Klebsiella ESBL+\|\|'''[[Has ESBL::S]]'''
	\|-		\|-
	\| \|\|E coli/Klebsiella KPC+\|\|R		\| \|\|E coli/Klebsiella KPC+\|\|R

Ostermayer at 18:22, 18 July 2025

2025-07-18T18:22:24Z

← Older revision		Revision as of 18:22, 18 July 2025
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	\| \|\|[[Acinetobacter sp.]]\|\|I		\| \|\|[[Acinetobacter sp.]]\|\|I
	\|-		\|-
	\| \|\|[[Pseudomonas aeruginosa]]\|\|'''S'''		\| \|\|[[Pseudomonas aeruginosa]]\|\|'''[[Has Antipseudomonal::S]]'''
	\|-		\|-
	\| \|\|[[Burkholderia cepacia]]\|\|R		\| \|\|[[Burkholderia cepacia]]\|\|R

Ostermayer at 17:10, 18 July 2025

2025-07-18T17:10:42Z

← Older revision		Revision as of 17:10, 18 July 2025
Line 1:		Line 1:
	==General==		==General==
	*Type: [[Carbapenems]]		*Type: [[Is DrugClass::Carbapenems]]
	*Dosage Forms:		*Dosage Forms:
	*Common Trade Names: Primaxin		*Common Trade Names: Primaxin

ClaireLewis: /* References */

2019-09-22T20:45:52Z

References

← Older revision		Revision as of 20:45, 22 September 2019
Line 235:		Line 235:

	[[Category:Pharmacology]]		[[Category:Pharmacology]]
			[[Category:ID]]

Jonwarren: Contrainidcations and adverse reactions

2018-05-11T15:50:04Z

Contrainidcations and adverse reactions

@@ Line 9: / Line 9: @@
 *Moderately-susceptible organisms: 1g IV q6-8 hours
 *Max: Lower of 50mg/kg or 4 g/day
 ==Pediatric Dosing==
@@ Line 15: / Line 21: @@
 *First Dose: 10-16.6mg/kg IV x 1
 *Max: 4000mg/day
 ==Special Populations==
@@ Line 21: / Line 32: @@
 *Renal Dosing
 **Adult
 **Pediatric
 *Hepatic Dosing
-**Adult
+**Adult: Not defined
-**Pediatric
+**Pediatric: Not defined
 ==Contraindications==
@@ Line 31: / Line 71: @@
 ==Adverse Reactions==
 ===Serious===
 ===Common===
 ==Pharmacology==
-*Half-life:
+*Half-life: 1h
 *Metabolism:
-*Excretion:
+**Imipenem: Kidney
 *Mechanism of Action:
 ==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy 2014</ref>==

Mholtz at 23:02, 30 August 2017

2017-08-30T23:02:43Z

← Older revision		Revision as of 23:02, 30 August 2017
Line 2:		Line 2:
	*Type: [[Carbapenems]]		*Type: [[Carbapenems]]
	*Dosage Forms:		*Dosage Forms:
	*Common Trade Names:		*Common Trade Names: Primaxin

	==Adult Dosing==		==Adult Dosing==
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	*[[Antibiotics (Main)]]		*[[Antibiotics (Main)]]

	==~~Source~~==		==References==
			<references/>

	~~<references/>~~
	[[Category:Pharmacology]]		[[Category:Pharmacology]]