Inhaled nitric oxide - Revision history

Rossdonaldson1: Text replacement - "Hb" to "hemoglobin"

2016-08-01T10:49:04Z

Text replacement - "Hb" to "hemoglobin"

← Older revision		Revision as of 10:49, 1 August 2016
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	==Pharmacology==		==Pharmacology==
	*Half-life: 5 seconds		*Half-life: 5 seconds
	*Metabolism: reacts with oxyhemoglobin to form methemoglobin and nitrate, and also reacts with deoxy-Hb.		*Metabolism: reacts with oxyhemoglobin to form methemoglobin and nitrate, and also reacts with deoxy-hemoglobin.
	*Excretion: Renally; 70% of inhaled NO excreted within 48 hrs as nitrate in urine		*Excretion: Renally; 70% of inhaled NO excreted within 48 hrs as nitrate in urine

Rossdonaldson1: Text replacement - "HTN" to "hypertension"

2016-07-31T01:26:30Z

Text replacement - "HTN" to "hypertension"

← Older revision		Revision as of 01:26, 31 July 2016
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	==Indications==		==Indications==
	*Pulmonary ~~HTN~~ of newborn		*Pulmonary hypertension of newborn
	*Pulmonary ~~HTN~~ of adults		*Pulmonary hypertension of adults
	*Cystic Fibrosis		*Cystic Fibrosis
	*ARDS		*ARDS

Hacharya at 05:04, 27 April 2016

2016-04-27T05:04:52Z

← Older revision		Revision as of 05:04, 27 April 2016
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	*Half-life: 5 seconds		*Half-life: 5 seconds
	*Metabolism: reacts with oxyhemoglobin to form methemoglobin and nitrate, and also reacts with deoxy-Hb.		*Metabolism: reacts with oxyhemoglobin to form methemoglobin and nitrate, and also reacts with deoxy-Hb.
	*Excretion: ~~Renaly~~; 70% of inhaled NO excreted within 48 hrs as nitrate in urine		*Excretion: Renally; 70% of inhaled NO excreted within 48 hrs as nitrate in urine

	==Mechanism of Action==		==Mechanism of Action==

Hacharya at 00:04, 27 April 2016

2016-04-27T00:04:36Z

← Older revision		Revision as of 00:04, 27 April 2016
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	==Administration==		==Administration==
	*Type: Inhalational agent		*Type: Inhalational agent
	*Dosage Forms: Metal cylinders		*Dosage Forms: Metal cylinders, 100 ppm and 800 ppm
	*Routes of Administration: Inhaled		*Routes of Administration: Inhaled
	*Common Trade Names:		*Common Trade Names: INOmax

	==Adult Dosing==		==Adult Dosing==
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	==Pediatric Dosing==		==Pediatric Dosing==
			20 ppm

	==Special Populations==		==Special Populations==
	*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]:		*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: C
	*[[Lactation risk categories\|Lactation risk]]:		*[[Lactation risk categories\|Lactation risk]]: Unknown
	===Renal Dosing===		===Renal Dosing===
	*Adult:		*Adult:
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	===Common===		===Common===
			*Hypotension
			*Withdrawal

	==Pharmacology==		==Pharmacology==
	*Half-life: 5 seconds		*Half-life: 5 seconds
	*Metabolism: reacts with oxyhemoglobin to form methemoglobin and nitrate, and also reacts with deoxy-Hb.		*Metabolism: reacts with oxyhemoglobin to form methemoglobin and nitrate, and also reacts with deoxy-Hb.
	*Excretion: ~~Urinary~~; 70% of inhaled NO excreted within 48 hrs as nitrate		*Excretion: Renaly; 70% of inhaled NO excreted within 48 hrs as nitrate in urine

	==Mechanism of Action==		==Mechanism of Action==
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	*Pulmonary HTN of newborn		*Pulmonary HTN of newborn
	*Pulmonary HTN of adults		*Pulmonary HTN of adults
			*Cystic Fibrosis
			*ARDS
	*Right heart failure (post-VAD, transplant, post cardiac surgery)		*Right heart failure (post-VAD, transplant, post cardiac surgery)
	*Graft failure post lung transplant		*Graft failure post lung transplant
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	==References==		==References==
	*Ichinose F, Roberts JD Jr, Zapol WM. Inhaled nitric oxide: a selective pulmonary vasodilator: current uses and therapeutic potential. Circulation. 2004 Jun 29;109(25):3106-11. Review. PubMed PMID: 15226227.		*Ichinose F, Roberts JD Jr, Zapol WM. Inhaled nitric oxide: a selective pulmonary vasodilator: current uses and therapeutic potential. Circulation. 2004 Jun 29;109(25):3106-11. Review. PubMed PMID: 15226227.
			*Medscape
	<references/>		<references/>
	[[Category:Pharmacology]]		[[Category:Pharmacology]]

Hacharya: /* Administration */

2016-04-26T23:59:03Z

Administration

← Older revision		Revision as of 23:59, 26 April 2016
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	==Administration==		==Administration==
	*Type: ~~inhalational~~ agent		*Type: Inhalational agent
	*Dosage Forms: ~~metal~~ cylinders		*Dosage Forms: Metal cylinders
	*Routes of Administration: ~~inhaled~~		*Routes of Administration: Inhaled
	*Common Trade Names:		*Common Trade Names:

	==Adult Dosing==		==Adult Dosing==

Hacharya at 23:58, 26 April 2016

2016-04-26T23:58:35Z

← Older revision		Revision as of 23:58, 26 April 2016
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	==Administration==		==Administration==
	*Type: ~~Vasodilator~~		*Type: inhalational agent
	*Dosage Forms:		*Dosage Forms: metal cylinders
	*Routes of Administration:		*Routes of Administration: inhaled
	*Common Trade Names:		*Common Trade Names:

	==Adult Dosing==		==Adult Dosing==
			5 - 80 ppm

	==Pediatric Dosing==		==Pediatric Dosing==
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	==Adverse Reactions==		==Adverse Reactions==
	===Serious===		===Serious===
			*Hypotension
			*Inhibits platelets - bleeding
			*Rebound htn and hypoxia
			*Renal failure

	===Common===		===Common===

	==Pharmacology==		==Pharmacology==
	*Half-life:		*Half-life: 5 seconds
	*Metabolism: reacts with oxyhemoglobin to form methemoglobin and nitrate, and also reacts with deoxy-Hb.		*Metabolism: reacts with oxyhemoglobin to form methemoglobin and nitrate, and also reacts with deoxy-Hb.
	*Excretion: Urinary; 70% of inhaled NO excreted within 48 hrs as nitrate		*Excretion: Urinary; 70% of inhaled NO excreted within 48 hrs as nitrate

	==Mechanism of Action==		==Mechanism of Action==
	*Relaxes smooth muscle of pulmonary vessels via conversion of GTP to cGMP		*Acts via diffusion from alveoli
			*Relaxes smooth muscle of pulmonary vessels via conversion of GTP to cGMP, which activates a phosphorylatio cascade
	*Enhances V/Q matching by increasing blood flow to well-ventilated areas of lung		*Enhances V/Q matching by increasing blood flow to well-ventilated areas of lung
			*Decreases PVR
			*Decreases PA pressure

	==Indications==		==Indications==
	*Pulmonary HTN of newborn		*Pulmonary HTN of newborn
	*Pulmonary HTN of adults		*Pulmonary HTN of adults
			*Right heart failure (post-VAD, transplant, post cardiac surgery)
			*Graft failure post lung transplant

	==Comments==		==Comments==
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	==References==		==References==
	*Inhaled ~~Nitric Oxide~~: ~~A Selective Pulmonary Vasodilator~~: ~~Current Uses~~ and ~~Therapeutic Potential~~. Circulation.		*Ichinose F, Roberts JD Jr, Zapol WM. Inhaled nitric oxide: a selective pulmonary vasodilator: current uses and therapeutic potential. Circulation. 2004 Jun 29;109(25):3106-11. Review. PubMed PMID: 15226227.
	2004; 109: 3106-~~3111~~
	<references/>		<references/>
	[[Category:Pharmacology]]		[[Category:Pharmacology]]

Hacharya at 23:52, 26 April 2016

2016-04-26T23:52:01Z

← Older revision		Revision as of 23:52, 26 April 2016
Line 1:		Line 1:
	==Administration==		==Administration==
	*Type:		*Type: Vasodilator
	*Dosage Forms:		*Dosage Forms:
	*Routes of Administration:		*Routes of Administration:
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	==Pharmacology==		==Pharmacology==
	*Half-life:		*Half-life:
	*Metabolism:		*Metabolism: reacts with oxyhemoglobin to form methemoglobin and nitrate, and also reacts with deoxy-Hb.
	*Excretion:		*Excretion: Urinary; 70% of inhaled NO excreted within 48 hrs as nitrate

	==Mechanism of Action==		==Mechanism of Action==
			*Relaxes smooth muscle of pulmonary vessels via conversion of GTP to cGMP
			*Enhances V/Q matching by increasing blood flow to well-ventilated areas of lung

			==Indications==
			*Pulmonary HTN of newborn
			*Pulmonary HTN of adults

	==Comments==		==Comments==
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	==References==		==References==
			*Inhaled Nitric Oxide: A Selective Pulmonary Vasodilator: Current Uses and Therapeutic Potential. Circulation.
			2004; 109: 3106-3111
	<references/>		<references/>
	[[Category:Pharmacology]]		[[Category:Pharmacology]]

Hacharya: Created page with "==Administration== Type: Dosage Forms: Routes of Administration: Common Trade Names: ==Adult Dosing== ==Pediatric Dosing== ==Special Populations== *Drug Ratings in..."

2016-04-26T22:57:47Z

Created page with "==Administration== *Type: *Dosage Forms: *Routes of Administration: *Common Trade Names: ==Adult Dosing== ==Pediatric Dosing== ==Special Populations== *Drug Ratings in..."

New page

==Administration==
*Type:
*Dosage Forms:
*Routes of Administration:
*Common Trade Names:

==Adult Dosing==

==Pediatric Dosing==

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]:
*[[Lactation risk categories|Lactation risk]]:
===Renal Dosing===
*Adult:
*Pediatric:
===Hepatic Dosing===
*Adult:
*Pediatric:

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===

===Common===

==Pharmacology==
*Half-life:
*Metabolism:
*Excretion:

==Mechanism of Action==

==Comments==

==See Also==

==References==
<references/>
[[Category:Pharmacology]]