Lassa fever - Revision history

ClaireLewis: /* Management */

2016-10-05T04:05:34Z

Management

← Older revision		Revision as of 04:05, 5 October 2016
Line 31:		Line 31:
	*Strict isolation precautions: standard, contact and droplet		*Strict isolation precautions: standard, contact and droplet
	**Limit entry and maintain a log of people who enter the room		**Limit entry and maintain a log of people who enter the room
	*Ribavirin has been shown to decrease mortality		*[[Ribavirin]] has been shown to decrease mortality
	**Most effective when given early (within 6 days)		**Most effective when given early (within 6 days)

Neil.m.young: Text replacement - "==Diagnostic Evaluation==" to "==Evaluation=="

2016-07-28T02:46:49Z

Text replacement - "==Diagnostic Evaluation==" to "==Evaluation=="

← Older revision		Revision as of 02:46, 28 July 2016
Line 23:		Line 23:
	{{Fever in Traveler DDX}}		{{Fever in Traveler DDX}}

	==~~Diagnostic~~ Evaluation==		==Evaluation==
	*IgM or IgG ELISA or RT-PCR may be used to diagnose acute infections		*IgM or IgG ELISA or RT-PCR may be used to diagnose acute infections
	*Lymphopenia and elevated transaminases are non-specific, but may indicate worse prognosis		*Lymphopenia and elevated transaminases are non-specific, but may indicate worse prognosis

Ostermayer: Text replacement - "Category:TropMed" to "Category:Tropical Medicine"

2016-03-22T16:59:17Z

Text replacement - "Category:TropMed" to "Category:Tropical Medicine"

← Older revision		Revision as of 16:59, 22 March 2016
Line 51:		Line 51:

	[[Category:ID]]		[[Category:ID]]
	[[Category:~~TropMed~~]]		[[Category:Tropical Medicine]]

Mholtz at 07:28, 7 September 2015

2015-09-07T07:28:58Z

← Older revision		Revision as of 07:28, 7 September 2015
Line 1:		Line 1:
	==Background==		==Background==
	*RNA virus of arenaviridae family		*RNA virus of arenaviridae family
	*~~endemic~~ to parts of West Africa		*Endemic to parts of West Africa
	**100,000-300,000 infections every year		**100,000-300,000 infections every year
	*Animal vector: Multimammate rat (Mastomys natalensis)		*Animal vector: Multimammate rat (''Mastomys natalensis'')
	*~~Lassa fever is a~~ [[viral hemorrhagic fever]]		*A type of [[viral hemorrhagic fevers\|viral hemorrhagic fever]]

	===Transmission===		===Transmission===
Line 28:		Line 28:

	==Management==		==Management==
	*~~Isolation~~ precautions: standard, contact and droplet		*Supportive care is the hallmark of management
	**Isolate in a single room with the door closed		*Strict isolation precautions: standard, contact and droplet
	**Limit entry and maintain a log of people who enter the room		**Limit entry and maintain a log of people who enter the room
	**Use standard, contact, and droplet precautions
	*Ribavirin has been shown to decrease mortality		*Ribavirin has been shown to decrease mortality
	**Most effective when given early (within 6 days)		**Most effective when given early (within 6 days)
	*Supportive care

	==Disposition==		==Disposition==
			*Admit (consider ICU admission)
	*Those that seek medical care are more likely to have serious infections:		*Those that seek medical care are more likely to have serious infections:
	**Hospital mortality rates can reach 25%		**Hospital mortality rates can reach 25%
	**Overal mortality rates are much less; around 5000 deaths per 100,000-300,000 infections annually		**Overal mortality rates are much less; around 5000 deaths per 100,000-300,000 infections annually
	*Admit, isolation, possible ICU for serologic results and clinical observation/supportive care

	==External Links==		==External Links==
	*~~Lassa Fever~~ http://www.cdc.gov/vhf/lassa/index.html		*[http://www.cdc.gov/vhf/lassa/index.html CDC Lassa Fever]

	==See Also==		==See Also==
	*[[Viral hemorrhagic ~~fever~~]]		*[[Viral hemorrhagic fevers]]

	==References==		==References==

Mholtz at 08:39, 6 September 2015

2015-09-06T08:39:07Z

← Older revision		Revision as of 08:39, 6 September 2015
Line 3:		Line 3:
	*endemic to parts of West Africa		*endemic to parts of West Africa
	**100,000-300,000 infections every year		**100,000-300,000 infections every year
	*Animal vector: Multimammate ~~Rat~~ (Mastomys natalensis)		*Animal vector: Multimammate rat (Mastomys natalensis)
	*Lassa fever is a [[viral hemorrhagic fever]]		*Lassa fever is a [[viral hemorrhagic fever]]

Line 23:		Line 23:
	{{Fever in Traveler DDX}}		{{Fever in Traveler DDX}}

	==~~=Diagnosis=~~==		==Diagnostic Evaluation==
	*IgM or IgG ELISA or RT-PCR may be used to diagnose acute infections		*IgM or IgG ELISA or RT-PCR may be used to diagnose acute infections
	*Lymphopenia and elevated transaminases are non-specific, ~~and~~ may indicate worse prognosis		*Lymphopenia and elevated transaminases are non-specific, but may indicate worse prognosis

	==Management==		==Management==
Line 41:		Line 41:
	**Overal mortality rates are much less; around 5000 deaths per 100,000-300,000 infections annually		**Overal mortality rates are much less; around 5000 deaths per 100,000-300,000 infections annually
	*Admit, isolation, possible ICU for serologic results and clinical observation/supportive care		*Admit, isolation, possible ICU for serologic results and clinical observation/supportive care

			==External Links==
			*Lassa Fever http://www.cdc.gov/vhf/lassa/index.html

	==See Also==		==See Also==
Line 46:		Line 49:

	==References==		==References==
	*Lassa Fever http://www.cdc.gov/vhf/lassa/index.html
	*McCormick JB, King IJ, Webb PA, Scribner CL, Craven RB, Johnson KM, Elliott LH, BelmontWilliams R. Lassa fever. Effective therapy with ribavirin. N Engl J Med. 1986;314:20–26.
	<references/>		<references/>


	[[Category:ID]]		[[Category:ID]]
	[[Category:TropMed]]		[[Category:TropMed]]

Rossdonaldson1: /* Differential Diagnosis */

2015-08-31T07:24:07Z

Differential Diagnosis

← Older revision		Revision as of 07:24, 31 August 2015
Line 21:		Line 21:

	==Differential Diagnosis==		==Differential Diagnosis==
	{{~~Template:~~Fever in Traveler DDX}}		{{Fever in Traveler DDX}}

	===Diagnosis===		===Diagnosis===

Rossdonaldson1 at 02:38, 10 June 2015

2015-06-10T02:38:23Z

← Older revision		Revision as of 02:38, 10 June 2015
Line 6:		Line 6:
	*Lassa fever is a [[viral hemorrhagic fever]]		*Lassa fever is a [[viral hemorrhagic fever]]

	==Transmission==		===Transmission===
	*Infected Multimammate rats shed virus in urine and droppings		*Infected Multimammate rats shed virus in urine and droppings
	*Inhalation, ingestion, or direct contact of excrement or soiled food		*Inhalation, ingestion, or direct contact of excrement or soiled food
Line 43:		Line 43:

	==See Also==		==See Also==
	[[~~viral~~ hemorrhagic fever]]		*[[Viral hemorrhagic fever]]

	==~~Sources~~==		==References==
	#Lassa Fever http://www.cdc.gov/vhf/lassa/index.html		*Lassa Fever http://www.cdc.gov/vhf/lassa/index.html
	~~#Rosen's~~		*McCormick JB, King IJ, Webb PA, Scribner CL, Craven RB, Johnson KM, Elliott LH, BelmontWilliams R. Lassa fever. Effective therapy with ribavirin. N Engl J Med. 1986;314:20–26.
	#McCormick JB, King IJ, Webb PA, Scribner CL, Craven RB, Johnson KM, Elliott LH, BelmontWilliams R. Lassa fever. Effective therapy with ribavirin. N Engl J Med. 1986;314:20–26.
	<references/>		<references/>

	[[Category:ID]]		[[Category:ID]]
	[[Category:TropMed]]		[[Category:TropMed]]

Rossdonaldson1: Rossdonaldson1 moved page Lassa to Lassa fever

2014-10-17T21:08:54Z

Rossdonaldson1 moved page Lassa to Lassa fever

← Older revision	Revision as of 21:08, 17 October 2014
(No difference)

Cchoff: Lassa fever

2014-10-15T01:52:11Z

Lassa fever

New page

==Background==
*RNA virus of arenaviridae family
*endemic to parts of West Africa
**100,000-300,000 infections every year
*Animal vector: Multimammate Rat (Mastomys natalensis)
*Lassa fever is a [[viral hemorrhagic fever]]

==Transmission==
*Infected Multimammate rats shed virus in urine and droppings
*Inhalation, ingestion, or direct contact of excrement or soiled food
*Direct contact with bodily fluids of infected human

==Clinical Features==
*Incubation period: 1-3 weeks
*80% of infections are mild
**Undiagnosed or low fever, malaise, headache
*20% of infections are severe
**vomiting, diarrhea, respiratory distress, facial swelling, body pain, hemorrhage, shock
**death within 2 weeks due to multi-system organ failure
*Occasional neurologic symptoms: hearing loss, tremors, encephalitis

==Differential Diagnosis==
{{Template:Fever in Traveler DDX}}

===Diagnosis===
*IgM or IgG ELISA or RT-PCR may be used to diagnose acute infections
*Lymphopenia and elevated transaminases are non-specific, and may indicate worse prognosis

==Management==
*Isolation precautions: standard, contact and droplet
**Isolate in a single room with the door closed
**Limit entry and maintain a log of people who enter the room
**Use standard, contact, and droplet precautions
*Ribavirin has been shown to decrease mortality
**Most effective when given early (within 6 days)
*Supportive care

==Disposition==
*Those that seek medical care are more likely to have serious infections:
**Hospital mortality rates can reach 25%
**Overal mortality rates are much less; around 5000 deaths per 100,000-300,000 infections annually
*Admit, isolation, possible ICU for serologic results and clinical observation/supportive care

==See Also==
[[viral hemorrhagic fever]]

==Sources==
#Lassa Fever http://www.cdc.gov/vhf/lassa/index.html
#Rosen's
#McCormick JB, King IJ, Webb PA, Scribner CL, Craven RB, Johnson KM, Elliott LH, BelmontWilliams R. Lassa fever. Effective therapy with ribavirin. N Engl J Med. 1986;314:20–26.
<references/>

[[Category:ID]]
[[Category:TropMed]]