Legionella - Revision history

ClaireLewis at 16:19, 14 September 2019

2019-09-14T16:19:27Z

@@ Line 1: / Line 1: @@
 ==Background==
 *[[Gram negative]] aerobe
-*''L. pneumophila:'' associated with pneumonia and Pontiac Fever
+*''L. pneumophila:'' associated with two distinct syndromes: pneumonia (legionnaires disease) and Pontiac Fever
-*Increased incidence with hot, humid, weather and thundershowers;  outbreaks have been associated with cooling towers.
+*Infection typically occurs via inhalation of aerosolized contaminated water or aspiration of contaminated water
 *Most commonly found in patients age > 50 years, smokers, immunocompromised.<ref>Cunha BA. Legionnaires' disease: clinical differentiation from typical and other atypical pneumonias. Infect Dis Clin N Am. 2010;24(1):73-105.</ref>
 ==Clinical Features==
 ==Differential Diagnosis==
@@ Line 12: / Line 39: @@
 ==Evaluation<ref>Cunha BA. Legionnaires' disease: clinical differentiation from typical and other atypical pneumonias. Infect Dis Clin N Am. 2010;24(1):73-105.</ref>==
 [[File:PMC5258191 cureus-0008-00000000937-i01.png|thumb|Severe case of Legionellosis on CXR]]
 *Na: Low in CAP but mostly frequently associated with Legionella
 *AST/ALT: Mildly increased 2-5x normal
@@ Line 20: / Line 49: @@
 ==Management==
 *First line
 **[[Azithromycin]]

Rossdonaldson1: /* Background */

2019-03-06T07:00:19Z

Background

← Older revision		Revision as of 07:00, 6 March 2019
Line 4:		Line 4:
	*Increased incidence with hot, humid, weather and thundershowers; outbreaks have been associated with cooling towers.		*Increased incidence with hot, humid, weather and thundershowers; outbreaks have been associated with cooling towers.
	*Most commonly found in patients age > 50 years, smokers, immunocompromised.<ref>Cunha BA. Legionnaires' disease: clinical differentiation from typical and other atypical pneumonias. Infect Dis Clin N Am. 2010;24(1):73-105.</ref>		*Most commonly found in patients age > 50 years, smokers, immunocompromised.<ref>Cunha BA. Legionnaires' disease: clinical differentiation from typical and other atypical pneumonias. Infect Dis Clin N Am. 2010;24(1):73-105.</ref>

			==Clinical Features==

	==Differential Diagnosis==		==Differential Diagnosis==

Rossdonaldson1: /* EvaluationCunha BA. Legionnaires' disease: clinical differentiation from typical and other atypical pneumonias. Infect Dis Clin N Am. 2010;24(1):73-105. */

2019-03-06T07:00:01Z

EvaluationCunha BA. Legionnaires' disease: clinical differentiation from typical and other atypical pneumonias. Infect Dis Clin N Am. 2010;24(1):73-105.

← Older revision		Revision as of 07:00, 6 March 2019
Line 9:		Line 9:

	==Evaluation<ref>Cunha BA. Legionnaires' disease: clinical differentiation from typical and other atypical pneumonias. Infect Dis Clin N Am. 2010;24(1):73-105.</ref>==		==Evaluation<ref>Cunha BA. Legionnaires' disease: clinical differentiation from typical and other atypical pneumonias. Infect Dis Clin N Am. 2010;24(1):73-105.</ref>==
	[File:PMC5258191 cureus-0008-00000000937-i01.png\|thumb\|Severe case of Legionellosis on CXR]]		[[File:PMC5258191 cureus-0008-00000000937-i01.png\|thumb\|Severe case of Legionellosis on CXR]]
	*Na: Low in CAP but mostly frequently associated with Legionella		*Na: Low in CAP but mostly frequently associated with Legionella
	*AST/ALT: Mildly increased 2-5x normal		*AST/ALT: Mildly increased 2-5x normal

Rossdonaldson1: /* EvaluationCunha BA. Legionnaires' disease: clinical differentiation from typical and other atypical pneumonias. Infect Dis Clin N Am. 2010;24(1):73-105. */

2019-03-06T06:59:44Z

EvaluationCunha BA. Legionnaires' disease: clinical differentiation from typical and other atypical pneumonias. Infect Dis Clin N Am. 2010;24(1):73-105.

← Older revision		Revision as of 06:59, 6 March 2019
Line 9:		Line 9:

	==Evaluation<ref>Cunha BA. Legionnaires' disease: clinical differentiation from typical and other atypical pneumonias. Infect Dis Clin N Am. 2010;24(1):73-105.</ref>==		==Evaluation<ref>Cunha BA. Legionnaires' disease: clinical differentiation from typical and other atypical pneumonias. Infect Dis Clin N Am. 2010;24(1):73-105.</ref>==
			[File:PMC5258191 cureus-0008-00000000937-i01.png\|thumb\|Severe case of Legionellosis on CXR]]
	*Na: Low in CAP but mostly frequently associated with Legionella		*Na: Low in CAP but mostly frequently associated with Legionella
	*AST/ALT: Mildly increased 2-5x normal		*AST/ALT: Mildly increased 2-5x normal

Adamhaag at 18:17, 20 August 2017

2017-08-20T18:17:09Z

← Older revision		Revision as of 18:17, 20 August 2017
Line 8:		Line 8:
	{{Causes of pneumonia}}		{{Causes of pneumonia}}

	==Evaluation==<ref>Cunha BA. Legionnaires' disease: clinical differentiation from typical and other atypical pneumonias. Infect Dis Clin N Am. 2010;24(1):73-105.</ref>		==Evaluation<ref>Cunha BA. Legionnaires' disease: clinical differentiation from typical and other atypical pneumonias. Infect Dis Clin N Am. 2010;24(1):73-105.</ref>==
	*Na: Low in CAP but mostly frequently associated with Legionella		*Na: Low in CAP but mostly frequently associated with Legionella
	*AST/ALT: Mildly increased 2-5x normal		*AST/ALT: Mildly increased 2-5x normal

Adamhaag at 18:16, 20 August 2017

2017-08-20T18:16:13Z

← Older revision		Revision as of 18:16, 20 August 2017
Line 8:		Line 8:
	{{Causes of pneumonia}}		{{Causes of pneumonia}}

	==Evaluation<ref>Cunha BA. Legionnaires' disease: clinical differentiation from typical and other atypical pneumonias. Infect Dis Clin N Am. 2010;24(1):73-105.</ref>		==Evaluation==<ref>Cunha BA. Legionnaires' disease: clinical differentiation from typical and other atypical pneumonias. Infect Dis Clin N Am. 2010;24(1):73-105.</ref>
	*Na: Low in CAP but mostly frequently associated with Legionella		*Na: Low in CAP but mostly frequently associated with Legionella
	*AST/ALT: Mildly increased 2-5x normal		*AST/ALT: Mildly increased 2-5x normal

Adamhaag at 18:15, 20 August 2017

2017-08-20T18:15:36Z

← Older revision		Revision as of 18:15, 20 August 2017
Line 7:		Line 7:
	==Differential Diagnosis==		==Differential Diagnosis==
	{{Causes of pneumonia}}		{{Causes of pneumonia}}

			==Evaluation<ref>Cunha BA. Legionnaires' disease: clinical differentiation from typical and other atypical pneumonias. Infect Dis Clin N Am. 2010;24(1):73-105.</ref>
			*Na: Low in CAP but mostly frequently associated with Legionella
			*AST/ALT: Mildly increased 2-5x normal
			*Phosphate: Decreased
			*CK: Increased
			*CRP: > 35
			*Ferritin: Increased >2x normal

	==Management==		==Management==

Adamhaag at 18:12, 20 August 2017

2017-08-20T18:12:56Z

← Older revision		Revision as of 18:12, 20 August 2017
Line 3:		Line 3:
	*''L. pneumophila:'' associated with pneumonia and Pontiac Fever		*''L. pneumophila:'' associated with pneumonia and Pontiac Fever
	*Increased incidence with hot, humid, weather and thundershowers; outbreaks have been associated with cooling towers.		*Increased incidence with hot, humid, weather and thundershowers; outbreaks have been associated with cooling towers.
			*Most commonly found in patients age > 50 years, smokers, immunocompromised.<ref>Cunha BA. Legionnaires' disease: clinical differentiation from typical and other atypical pneumonias. Infect Dis Clin N Am. 2010;24(1):73-105.</ref>

	==Differential Diagnosis==		==Differential Diagnosis==

Mholtz: Text replacement - "* " to "*"

2017-07-16T02:36:55Z

Text replacement - "* " to "*"

← Older revision		Revision as of 02:36, 16 July 2017
Line 1:		Line 1:
	==Background==		==Background==
	*[[Gram negative]] aerobe		*[[Gram negative]] aerobe
	* ''L. pneumophila:'' associated with pneumonia and Pontiac Fever		*''L. pneumophila:'' associated with pneumonia and Pontiac Fever
	*Increased incidence with hot, humid, weather and thundershowers; outbreaks have been associated with cooling towers.		*Increased incidence with hot, humid, weather and thundershowers; outbreaks have been associated with cooling towers.

Rossdonaldson1: /* Background */

2017-03-20T20:04:15Z

Background

← Older revision		Revision as of 20:04, 20 March 2017
Line 1:		Line 1:
	==Background==		==Background==
	*Gram negative aerobe		*[[Gram negative]] aerobe
	* ''L. pneumophila:'' associated with pneumonia and Pontiac Fever		* ''L. pneumophila:'' associated with pneumonia and Pontiac Fever
	*Increased incidence with hot, humid, weather and thundershowers; outbreaks have been associated with cooling towers.		*Increased incidence with hot, humid, weather and thundershowers; outbreaks have been associated with cooling towers.