Leucovorin - Revision history

Danbot: Remove refs with incorrect PMIDs (verified against PubMed)

2026-03-22T10:25:13Z

Remove refs with incorrect PMIDs (verified against PubMed)

← Older revision		Revision as of 10:25, 22 March 2026
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	==Administration==		==Administration==
	*Type: Antidote; Chemotherapy Modulating Agent; Rescue Agent (Chemotherapy)~~<ref>Green JM. Glucarpidase to combat toxic levels of methotrexate in patients. Ther Clin Risk Manag. 2012;8:403-413. PMID 23204846</ref>~~		*Type: Antidote; Chemotherapy Modulating Agent; Rescue Agent (Chemotherapy)
	*Dosage Forms: 5,10,15,25		*Dosage Forms: 5,10,15,25
	*Routes of Administration: IV, IM		*Routes of Administration: IV, IM

Danbot: Add peer-reviewed reference

2026-03-22T10:16:42Z

Add peer-reviewed reference

← Older revision		Revision as of 10:16, 22 March 2026
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	==Administration==		==Administration==
	*Type: Antidote; Chemotherapy Modulating Agent; Rescue Agent (Chemotherapy)		*Type: Antidote; Chemotherapy Modulating Agent; Rescue Agent (Chemotherapy)<ref>Green JM. Glucarpidase to combat toxic levels of methotrexate in patients. Ther Clin Risk Manag. 2012;8:403-413. PMID 23204846</ref>
	*Dosage Forms: 5,10,15,25		*Dosage Forms: 5,10,15,25
	*Routes of Administration: IV, IM		*Routes of Administration: IV, IM

Danbot: Restore original dosing content alongside dynamic SMW tables

2026-03-20T02:37:50Z

Restore original dosing content alongside dynamic SMW tables

← Older revision		Revision as of 02:37, 20 March 2026
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	==Adult Dosing==		==Adult Dosing==
			*Fluorouracil adjuvant treatment, adv. colorectal CA
			**high dose: 200mg/m^2 IV QD x5 days
			**low dose: 20mg/m^2 IV QD x5 days

			*Leucovorin rescue, high-dose [[methotrexate]]
			**normal methotrexate elimination: 15mg PO/IM/IV q6h x10 doses
			**delayed late methotrexate elimination: 15mg PO/IM/IV q6h; Max: 25mg/dose PO, May give higher doses IM/IV

			*Delayed early methotrexate elimination and/or acute renal injury: 150mg IV q3h until methotrexate level <1 micromolar, then 15mg IV q3h

			*Leucovorin rescue, methotrexate overdose: 10mg/m^2 PO/IM/IV q6h

			*Folate antagonist overdose
			**pemetrexed: 50mg/m^2 IV q6h x8 days; Start: 100mg/m^2 IV x1
			**pyrimethamine, trimethoprim: 5-15mg PO/IM/IV QD until hematopoiesis restored

			*Megaloblastic anemia, folate-deficient: <1mg IM/IV QD
			**Max: 1mg/day


	===Indications by Disease===		===Indications by Disease===
	{{#ask: [[Has DrugName::Leucovorin]] [[Has Population::Adult]]		{{#ask: [[Has DrugName::Leucovorin]] [[Has Population::Adult]]
	\|?Treats disease=Disease		\|?Treats disease=Disease
	\|?Has Dose=Dose		\|?Has Dose=Dose
	\|?Has Context=Context		\|?Has Context=Context
	\|format=table		\|format=table
	\|limit=50		\|limit=50
	\|mainlabel=-		\|mainlabel=-
	\|headers=show		\|headers=show
	\|sort=Treats disease		\|sort=Treats disease
	}}		}}

	==Pediatric Dosing==		==Pediatric Dosing==
			*Leucovorin rescue, high-dose methotrexate
			**normal methotrexate elimination: 10mg/m^2 PO/IM/IV q6h x10 doses; Start: 24h after methotrexate start; Max: 25mg/dose PO
			**delayed late methotrexate elimination: 10mg/m^2 PO/IM/IV q6h; Max: 25mg/dose PO
			**delayed early methotrexate elimination and/or acute renal injury: 100mg/m^2 IV q3h until methotrexate level <1 micromolar, then 10mg/m^2 IV q3

			*Leucovorin rescue, methotrexate overdose: 10mg/m^2 PO/IM/IV q6h

			*Folate antagonist overdose: 5-15mg PO/IM/IV QD until hematopoiesis restored

			*Megaloblastic anemia, folate-deficient: <1mg IM/IV QD
			**Max: 1mg/day


	===Indications by Disease===		===Indications by Disease===
	{{#ask: [[Has DrugName::Leucovorin]] [[Has Population::Pediatric]]		{{#ask: [[Has DrugName::Leucovorin]] [[Has Population::Pediatric]]
	\|?Treats disease=Disease		\|?Treats disease=Disease
	\|?Has Dose=Dose		\|?Has Dose=Dose
	\|?Has Context=Context		\|?Has Context=Context
	\|format=table		\|format=table
	\|limit=50		\|limit=50
	\|mainlabel=-		\|mainlabel=-
	\|headers=show		\|headers=show
	\|sort=Treats disease		\|sort=Treats disease
	}}		}}

Danbot: Replace manual dosing with dynamic SMW tables (Adult + Pediatric)

2026-03-20T01:53:44Z

Replace manual dosing with dynamic SMW tables (Adult + Pediatric)

← Older revision		Revision as of 01:53, 20 March 2026
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	==Adult Dosing==		==Adult Dosing==
	*Fluorouracil adjuvant treatment, adv. colorectal CA		===Indications by Disease===
	**high dose: ~~200mg/m^2 IV QD x5 days~~		{{#ask: [[Has DrugName::Leucovorin]] [[Has Population::Adult]]
	**low dose: ~~20mg/m^2 IV QD x5 days~~		\|?Treats disease=Disease
			\|?Has Dose=Dose
	*Leucovorin ~~rescue, high-dose~~ [[~~methotrexate~~]]		\|?Has Context=Context
	**normal methotrexate elimination: 15mg PO/IM/IV q6h x10 doses		\|format=table
	**delayed late methotrexate elimination: 15mg PO/IM/IV q6h; Max: 25mg/dose PO, May give higher doses IM/IV		\|limit=50
			\|mainlabel=-
	*Delayed early methotrexate elimination and/or acute renal injury: 150mg IV q3h until methotrexate level <1 micromolar, then 15mg IV q3h		\|headers=show
			\|sort=Treats disease
	*Leucovorin rescue, methotrexate overdose: 10mg/m^2 PO/IM/IV q6h		}}

	*Folate antagonist overdose
	**pemetrexed: 50mg/m^2 IV q6h x8 days; Start: 100mg/m^2 IV x1
	**pyrimethamine, trimethoprim: 5-~~15mg PO/IM/IV QD until hematopoiesis restored~~

	*Megaloblastic anemia, folate-deficient: <1mg IM/IV QD
	**Max: 1mg/day

	==Pediatric Dosing==		==Pediatric Dosing==
	*Leucovorin rescue, high-dose methotrexate		===Indications by Disease===
	**normal methotrexate elimination: ~~10mg/m^2 PO/IM/IV q6h x10 doses; Start~~: ~~24h after methotrexate start; Max~~: ~~25mg/dose PO~~		{{#ask: [[Has DrugName::Leucovorin]] [[Has Population::Pediatric]]
	**delayed late methotrexate elimination: ~~10mg/m^2 PO/IM/IV q6h; Max~~: ~~25mg/dose PO~~		\|?Treats disease=Disease
	**delayed early methotrexate elimination and/or acute renal injury: 100mg/m^2 IV q3h until methotrexate level <1 micromolar, then 10mg/m^2 IV q3		\|?Has Dose=Dose
			\|?Has Context=Context
	*Leucovorin rescue, methotrexate overdose: 10mg/m^2 PO/IM/IV q6h		\|format=table
			\|limit=50
	*Folate antagonist overdose: 5-~~15mg PO/IM/IV QD until hematopoiesis restored~~		\|mainlabel=-
			\|headers=show
	*Megaloblastic anemia, folate-deficient: <1mg IM/IV QD		\|sort=Treats disease
	**Max: 1mg/day		}}

	==Special Populations==		==Special Populations==

ClaireLewis: /* References */

2019-09-22T22:52:15Z

References

← Older revision		Revision as of 22:52, 22 September 2019
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	==References==		==References==
	<Epocrates, UpToDate>		<Epocrates, UpToDate>
	[[Category:Pharmacology]]		[[Category:Pharmacology]] [[Category:Heme/Onc]]

Bmurray990: /* Special Populations */

2019-01-26T20:46:55Z

Special Populations

← Older revision		Revision as of 20:46, 26 January 2019
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	==Special Populations==		==Special Populations==
	*Pregnancy Risk Factor: C		*Pregnancy Risk Factor: C
			*Breast Feeding: Leucovorin is a form of folic acid and is present in breast milk which may be beneficial to the newborn.

	===Renal Dosing===		===Renal Dosing===

Mholtz: Text replacement - "qd" to "QD"

2017-07-07T12:57:34Z

Text replacement - "qd" to "QD"

← Older revision		Revision as of 12:57, 7 July 2017
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	==Adult Dosing==		==Adult Dosing==
	*Fluorouracil adjuvant treatment, adv. colorectal CA		*Fluorouracil adjuvant treatment, adv. colorectal CA
	**high dose: 200mg/m^2 IV qd x5 days		**high dose: 200mg/m^2 IV QD x5 days
	**low dose: 20mg/m^2 IV qd x5 days		**low dose: 20mg/m^2 IV QD x5 days

	*Leucovorin rescue, high-dose [[methotrexate]]		*Leucovorin rescue, high-dose [[methotrexate]]
Line 20:		Line 20:
	*Folate antagonist overdose		*Folate antagonist overdose
	**pemetrexed: 50mg/m^2 IV q6h x8 days; Start: 100mg/m^2 IV x1		**pemetrexed: 50mg/m^2 IV q6h x8 days; Start: 100mg/m^2 IV x1
	**pyrimethamine, trimethoprim: 5-15mg PO/IM/IV qd until hematopoiesis restored		**pyrimethamine, trimethoprim: 5-15mg PO/IM/IV QD until hematopoiesis restored

	*Megaloblastic anemia, folate-deficient: <1mg IM/IV qd		*Megaloblastic anemia, folate-deficient: <1mg IM/IV QD
	**Max: 1mg/day		**Max: 1mg/day

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	*Leucovorin rescue, methotrexate overdose: 10mg/m^2 PO/IM/IV q6h		*Leucovorin rescue, methotrexate overdose: 10mg/m^2 PO/IM/IV q6h

	*Folate antagonist overdose: 5-15mg PO/IM/IV qd until hematopoiesis restored		*Folate antagonist overdose: 5-15mg PO/IM/IV QD until hematopoiesis restored

	*Megaloblastic anemia, folate-deficient: <1mg IM/IV qd		*Megaloblastic anemia, folate-deficient: <1mg IM/IV QD
	**Max: 1mg/day		**Max: 1mg/day

ClaireLewis: /* Adult Dosing */

2016-08-30T14:33:31Z

Adult Dosing

← Older revision		Revision as of 14:33, 30 August 2016
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	**low dose: 20mg/m^2 IV qd x5 days		**low dose: 20mg/m^2 IV qd x5 days

	*Leucovorin rescue, high-dose methotrexate		*Leucovorin rescue, high-dose [[methotrexate]]
	**normal methotrexate elimination: 15mg PO/IM/IV q6h x10 doses		**normal methotrexate elimination: 15mg PO/IM/IV q6h x10 doses
	**delayed late methotrexate elimination: 15mg PO/IM/IV q6h; Max: 25mg/dose PO, May give higher doses IM/IV		**delayed late methotrexate elimination: 15mg PO/IM/IV q6h; Max: 25mg/dose PO, May give higher doses IM/IV

Neil.m.young: Text replacement - "0 mg" to "0mg"

2016-07-19T12:21:18Z

Text replacement - "0 mg" to "0mg"

← Older revision		Revision as of 12:21, 19 July 2016
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	==Adult Dosing==		==Adult Dosing==
	*Fluorouracil adjuvant treatment, adv. colorectal CA		*Fluorouracil adjuvant treatment, adv. colorectal CA
	**high dose: ~~200 mg~~/m^2 IV qd x5 days		**high dose: 200mg/m^2 IV qd x5 days
	**low dose: ~~20 mg~~/m^2 IV qd x5 days		**low dose: 20mg/m^2 IV qd x5 days

	*Leucovorin rescue, high-dose methotrexate		*Leucovorin rescue, high-dose methotrexate
Line 14:		Line 14:
	**delayed late methotrexate elimination: 15mg PO/IM/IV q6h; Max: 25mg/dose PO, May give higher doses IM/IV		**delayed late methotrexate elimination: 15mg PO/IM/IV q6h; Max: 25mg/dose PO, May give higher doses IM/IV

	*Delayed early methotrexate elimination and/or acute renal injury: ~~150 mg~~ IV q3h until methotrexate level <1 micromolar, then 15mg IV q3h		*Delayed early methotrexate elimination and/or acute renal injury: 150mg IV q3h until methotrexate level <1 micromolar, then 15mg IV q3h

	*Leucovorin rescue, methotrexate overdose: ~~10 mg~~/m^2 PO/IM/IV q6h		*Leucovorin rescue, methotrexate overdose: 10mg/m^2 PO/IM/IV q6h

	*Folate antagonist overdose		*Folate antagonist overdose
	**pemetrexed: ~~50 mg~~/m^2 IV q6h x8 days; Start: ~~100 mg~~/m^2 IV x1		**pemetrexed: 50mg/m^2 IV q6h x8 days; Start: 100mg/m^2 IV x1
	**pyrimethamine, trimethoprim: 5-15mg PO/IM/IV qd until hematopoiesis restored		**pyrimethamine, trimethoprim: 5-15mg PO/IM/IV qd until hematopoiesis restored

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	==Pediatric Dosing==		==Pediatric Dosing==
	*Leucovorin rescue, high-dose methotrexate		*Leucovorin rescue, high-dose methotrexate
	**normal methotrexate elimination: ~~10 mg~~/m^2 PO/IM/IV q6h x10 doses; Start: 24h after methotrexate start; Max: 25mg/dose PO		**normal methotrexate elimination: 10mg/m^2 PO/IM/IV q6h x10 doses; Start: 24h after methotrexate start; Max: 25mg/dose PO
	**delayed late methotrexate elimination: ~~10 mg~~/m^2 PO/IM/IV q6h; Max: 25mg/dose PO		**delayed late methotrexate elimination: 10mg/m^2 PO/IM/IV q6h; Max: 25mg/dose PO
	**delayed early methotrexate elimination and/or acute renal injury: ~~100 mg~~/m^2 IV q3h until methotrexate level <1 micromolar, then ~~10 mg~~/m^2 IV q3		**delayed early methotrexate elimination and/or acute renal injury: 100mg/m^2 IV q3h until methotrexate level <1 micromolar, then 10mg/m^2 IV q3

	*Leucovorin rescue, methotrexate overdose: ~~10 mg~~/m^2 PO/IM/IV q6h		*Leucovorin rescue, methotrexate overdose: 10mg/m^2 PO/IM/IV q6h

	*Folate antagonist overdose: 5-15mg PO/IM/IV qd until hematopoiesis restored		*Folate antagonist overdose: 5-15mg PO/IM/IV qd until hematopoiesis restored

Neil.m.young: Text replacement - "5 mg" to "5mg"

2016-07-19T10:47:38Z

Text replacement - "5 mg" to "5mg"

← Older revision		Revision as of 10:47, 19 July 2016
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	*Leucovorin rescue, high-dose methotrexate		*Leucovorin rescue, high-dose methotrexate
	**normal methotrexate elimination: ~~15 mg~~ PO/IM/IV q6h x10 doses		**normal methotrexate elimination: 15mg PO/IM/IV q6h x10 doses
	**delayed late methotrexate elimination: ~~15 mg~~ PO/IM/IV q6h; Max: ~~25 mg~~/dose PO, May give higher doses IM/IV		**delayed late methotrexate elimination: 15mg PO/IM/IV q6h; Max: 25mg/dose PO, May give higher doses IM/IV

	*Delayed early methotrexate elimination and/or acute renal injury: 150 mg IV q3h until methotrexate level <1 micromolar, then ~~15 mg~~ IV q3h		*Delayed early methotrexate elimination and/or acute renal injury: 150 mg IV q3h until methotrexate level <1 micromolar, then 15mg IV q3h

	*Leucovorin rescue, methotrexate overdose: 10 mg/m^2 PO/IM/IV q6h		*Leucovorin rescue, methotrexate overdose: 10 mg/m^2 PO/IM/IV q6h
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	*Folate antagonist overdose		*Folate antagonist overdose
	**pemetrexed: 50 mg/m^2 IV q6h x8 days; Start: 100 mg/m^2 IV x1		**pemetrexed: 50 mg/m^2 IV q6h x8 days; Start: 100 mg/m^2 IV x1
	**pyrimethamine, trimethoprim: 5-~~15 mg~~ PO/IM/IV qd until hematopoiesis restored		**pyrimethamine, trimethoprim: 5-15mg PO/IM/IV qd until hematopoiesis restored

	*Megaloblastic anemia, folate-deficient: <1mg IM/IV qd		*Megaloblastic anemia, folate-deficient: <1mg IM/IV qd
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	==Pediatric Dosing==		==Pediatric Dosing==
	*Leucovorin rescue, high-dose methotrexate		*Leucovorin rescue, high-dose methotrexate
	**normal methotrexate elimination: 10 mg/m^2 PO/IM/IV q6h x10 doses; Start: 24h after methotrexate start; Max: ~~25 mg~~/dose PO		**normal methotrexate elimination: 10 mg/m^2 PO/IM/IV q6h x10 doses; Start: 24h after methotrexate start; Max: 25mg/dose PO
	**delayed late methotrexate elimination: 10 mg/m^2 PO/IM/IV q6h; Max: ~~25 mg~~/dose PO		**delayed late methotrexate elimination: 10 mg/m^2 PO/IM/IV q6h; Max: 25mg/dose PO
	**delayed early methotrexate elimination and/or acute renal injury: 100 mg/m^2 IV q3h until methotrexate level <1 micromolar, then 10 mg/m^2 IV q3		**delayed early methotrexate elimination and/or acute renal injury: 100 mg/m^2 IV q3h until methotrexate level <1 micromolar, then 10 mg/m^2 IV q3

	*Leucovorin rescue, methotrexate overdose: 10 mg/m^2 PO/IM/IV q6h		*Leucovorin rescue, methotrexate overdose: 10 mg/m^2 PO/IM/IV q6h

	*Folate antagonist overdose: 5-~~15 mg~~ PO/IM/IV qd until hematopoiesis restored		*Folate antagonist overdose: 5-15mg PO/IM/IV qd until hematopoiesis restored

	*Megaloblastic anemia, folate-deficient: <1mg IM/IV qd		*Megaloblastic anemia, folate-deficient: <1mg IM/IV qd