https://wikem.org/w/index.php?action=history&feed=atom&title=Limbic_encephalitisLimbic encephalitis - Revision history2026-04-17T16:07:49ZRevision history for this page on the wikiMediaWiki 1.38.2https://wikem.org/w/index.php?title=Limbic_encephalitis&diff=224643&oldid=prevClaireLewis: Created page with "==Background== *Autoimmune encephalitis caused by autoantibodies against intracellular neuronal proteins *Typically not limited to limbic system *Majority of cases are p..."2019-08-16T18:37:47Z<p>Created page with "==Background== *Autoimmune <a href="/wiki/Encephalitis" title="Encephalitis">encephalitis</a> caused by autoantibodies against intracellular neuronal proteins *Typically not limited to limbic system *Majority of cases are p..."</p>
<p><b>New page</b></p><div>==Background==<br />
*Autoimmune [[encephalitis]] caused by autoantibodies against intracellular neuronal proteins<br />
*Typically not limited to limbic system<br />
*Majority of cases are [[paraneoplastic]], particularly associated with small cell lung cancer, germ-cell testicular tumors, teratomas<br />
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==Clinical Features==<br />
*Mimics [[HSV]] encephalitis<br />
*Subacute presentation over days to weeks<br />
*Short-term memory deficits<br />
*[[Headache]]<br />
*Irritability, sleep disturbance, [[agitation]]<br />
*Delusions, [[hallucinations]], [[psychosis]]<br />
*[[Seizure]]<br />
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==Differential Diagnosis==<br />
{{AMS DDX}}<br />
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==Evaluation==<br />
*Diagnosis unlikely to be made in the ED<br />
*Evaluate for alternative diagnoses<br />
*[[MRI Brain]]- usually increased T2 signal involving one or both temporal lobes.<ref>Nicholas, D (2003). "Clinical, Magnetic Resonance Imaging, and 7Electroencephalographic Findings in Paraneoplastic Limbic Encephalitis". Mayo Clinic Proceedings. 78 (11): 1363–1368.</ref><br />
*[[LP]]- CSF w/lymphocytosis (though usually <100), elevated protein, normal glucose, elevated IgG index, oligoclonal bands<ref>Vincent A, Buckley C, Schott JM, et al. (2004). "Potassium channel antibody-associated encephalopathy: a potentially immunotherapy-responsive form of limbic encephalitis". Brain. 127 (3): 701–712</ref><br />
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==Management==<br />
*No randomized trials but may include [[IVIG]], [[plasmapheresis]], [[corticosteroids]], [[cyclophosphamide]] and/or [[rituximab]].<ref>Tüzün E, Dalmau J (2007). Limbic encephalitis and variants: classification, diagnosis and treatment. The Neurologist. 13 (5).</ref> <br />
*Treat underlying malignancy<br />
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==Disposition==<br />
*Admit<br />
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==See Also==<br />
*[[Encephalitis]]<br />
*[[Paraneoplastic syndromes]]<br />
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==External Links==<br />
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==References==<br />
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[[Category:Neurology]]</div>ClaireLewis