Mannitol - Revision history

Danbot: Switch SMW query from broadtable to table format for better layout with TOC

2026-03-20T21:57:04Z

Switch SMW query from broadtable to table format for better layout with TOC

2026-03-20T17:45:57Z

Add Indications by Condition SMW query table

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 *Excretion: Urine
 *Mechanism of Action: Increased tonicity of mannitol draws water out of the brain parenchyma and into the intravascular space<ref>https://www.ncbi.nlm.nih.gov/books/NBK470392/#:~:text=Tenny%20S%2C%20Patel%20R%2C%20Thorell%20W.%20Mannitol.%20%5BUpdated%202022%20Feb%2021%5D.%20In%3A%20StatPearls%20%5BInternet%5D.%20Treasure%20Island%20(FL)%3A%20StatPearls%20Publishing%3B%202022%20Jan%2D.%20Available%20from%3A%20https%3A//www.ncbi.nlm.nih.gov/books/NBK470392/</ref>
 ==See Also==

2022-10-02T14:37:50Z

Adverse Reactions

2022-10-02T14:34:08Z

Pharmacology

← Older revision		Revision as of 14:34, 2 October 2022
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	==Pharmacology==		==Pharmacology==
	*Half-life:		*Onset of action: 5-10 minutes
			*Half-life: 6 hours
	*Metabolism:		*Metabolism:
	*Excretion:		*Excretion: Urine
	*Mechanism of Action:		*Mechanism of Action: Increased tonicity of mannitol draws water out of the brain parenchyma and into the intravascular space<ref>https://www.ncbi.nlm.nih.gov/books/NBK470392/#:~:text=Tenny%20S%2C%20Patel%20R%2C%20Thorell%20W.%20Mannitol.%20%5BUpdated%202022%20Feb%2021%5D.%20In%3A%20StatPearls%20%5BInternet%5D.%20Treasure%20Island%20(FL)%3A%20StatPearls%20Publishing%3B%202022%20Jan%2D.%20Available%20from%3A%20https%3A//www.ncbi.nlm.nih.gov/books/NBK470392/</ref>

	==See Also==		==See Also==

2019-09-29T18:24:44Z

Elevated intracranial pressure

← Older revision		Revision as of 18:24, 29 September 2019
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	===Adult===		===Adult===
	====[[Elevated intracranial pressure]]====		====[[Elevated intracranial pressure]]====
	*0.25-2 G/kg given every 6 to 8 hours<ref>http://www.medicinenet.com/mannitol-injectable/article.htm</ref>		*0.25-2 g/kg given every 6 to 8 hours<ref>http://www.medicinenet.com/mannitol-injectable/article.htm</ref>
	**Should be given as a one time bolus (may be inferior to Hypertonic Saline)<ref>http://www.cochrane.org/CD001049/INJ_mannitol-for-acute-traumatic-brain-injury</ref>		**Should be given as a one time bolus (may be inferior to Hypertonic Saline)<ref>http://www.cochrane.org/CD001049/INJ_mannitol-for-acute-traumatic-brain-injury</ref>
	**Easy ED dosing: 1G/kg bolus in ED (while awaiting neurosurgery eval/admission)		**Easy ED dosing: 1g/kg bolus in ED (while awaiting neurosurgery eval/admission)

	===Pediatric Dosing===		===Pediatric Dosing===

2019-09-29T18:24:01Z

Elevated intracranial pressure

← Older revision		Revision as of 18:24, 29 September 2019
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	*0.25-2 G/kg given every 6 to 8 hours<ref>http://www.medicinenet.com/mannitol-injectable/article.htm</ref>		*0.25-2 G/kg given every 6 to 8 hours<ref>http://www.medicinenet.com/mannitol-injectable/article.htm</ref>
	**Should be given as a one time bolus (may be inferior to Hypertonic Saline)<ref>http://www.cochrane.org/CD001049/INJ_mannitol-for-acute-traumatic-brain-injury</ref>		**Should be given as a one time bolus (may be inferior to Hypertonic Saline)<ref>http://www.cochrane.org/CD001049/INJ_mannitol-for-acute-traumatic-brain-injury</ref>
	**Easy ED dosing: ~~1mg~~/kg bolus in ED (while awaiting neurosurgery eval/admission)		**Easy ED dosing: 1G/kg bolus in ED (while awaiting neurosurgery eval/admission)

	===Pediatric Dosing===		===Pediatric Dosing===

2019-04-02T19:36:29Z

References: added

← Older revision		Revision as of 19:36, 2 April 2019
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	==References==		==References==
	<references/>		<references/>
			* Mannitol (systemic): Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019.
	[[Category:Pharmacology]]		[[Category:Pharmacology]]

2019-04-02T19:35:45Z

Special Populations: added

← Older revision		Revision as of 19:35, 2 April 2019
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	*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: C		*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: C
	*Lactation:		*Lactation:
			** Unknown if present in breast milk
	*Renal Dosing		*Renal Dosing
	**Adult		**Adult
			*** Contraindicated in severe renal impairment
	**Pediatric		**Pediatric
			*** Contraindicated in severe renal impairment
	*Hepatic Dosing		*Hepatic Dosing
	**Adult		**Adult
			*** No adjustment necessary
	**Pediatric		**Pediatric
			*** No adjustment necessary

	==Indications==		==Indications==

2017-07-13T06:47:25Z

2016-07-27T11:28:10Z

Text replacement - "0 ml" to "0ml"

← Older revision		Revision as of 11:28, 27 July 2016
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	*Type: sugar alcohol, derived from mannose, stereo-isomer of sorbitol		*Type: sugar alcohol, derived from mannose, stereo-isomer of sorbitol
	*Dosage Forms: Reconstituted powder and solution<ref>[http://www.medicinenet.com/mannitol-injectable/article.htm</ref>		*Dosage Forms: Reconstituted powder and solution<ref>[http://www.medicinenet.com/mannitol-injectable/article.htm</ref>
	**5% and 10% in ~~1000 ml~~ containers		**5% and 10% in 1000ml containers
	**15% in ~~500 ml~~ containers		**15% in 500ml containers
	**20% in ~~250 ml~~ and ~~500 ml~~ containers		**20% in 250ml and 500ml containers
	**25% in ~~50 ml~~ flip-top vials		**25% in 50ml flip-top vials
	*Common Trade Names: Mannitol, Osmitrol		*Common Trade Names: Mannitol, Osmitrol