https://wikem.org/w/index.php?action=history&feed=atom&title=Methoxyflurane 2026-04-21T00:27:19Z Revision history for this page on the wiki MediaWiki 1.38.2 https://wikem.org/w/index.php?title=Methoxyflurane&diff=389789&oldid=prev 2026-03-25T02:52:24Z

<p>Created Methoxyflurane (Penthrox) medication page with standard template</p> <p><b>New page</b></p><div>==Administration==<br /> *Type: [[Analgesic]], inhaled<br /> *Dosage Forms: inhaler (3 mL liquid for inhalation)<br /> *Dosage Strengths: 3 mL per inhaler<br /> *Routes of Administration: Inhaled<br /> *Common Trade Names: Penthrox<br /> <br /> ==Adult Dosing==<br /> *3 mL inhaled via Penthrox inhaler, self-administered<br /> *May use up to 2 inhalers (6 mL) per day<br /> *Maximum: 6 mL per day, 15 mL per week<br /> <br /> ==Pediatric Dosing==<br /> *Age ≥12 years: same as adult dosing<br /> *Not recommended for children &lt;12 years<br /> <br /> ==Special Populations==<br /> ===[[Drug pregnancy categories|Pregnancy Rating]]===<br /> *Contraindicated<br /> <br /> ===Lactation risk===<br /> *Unknown; avoid use<br /> <br /> ===Renal Dosing===<br /> *Adult: Contraindicated in significant renal impairment<br /> *Pediatric: N/A<br /> <br /> ===Hepatic Dosing===<br /> *Adult: Contraindicated in significant hepatic impairment<br /> *Pediatric: N/A<br /> <br /> ==Contraindications==<br /> *Allergy to class/drug<br /> *Allergy to fluorinated anesthetics<br /> *History of [[malignant hyperthermia]]<br /> *Significant renal or hepatic impairment<br /> *Cardiovascular instability<br /> *Altered level of consciousness<br /> *Respiratory depression<br /> <br /> ==Adverse Reactions==<br /> ===Serious===<br /> *Nephrotoxicity (dose-dependent; risk with repeated/prolonged use)<br /> *Hepatotoxicity<br /> *[[Malignant hyperthermia]] (rare)<br /> <br /> ===Common===<br /> *Dizziness, drowsiness<br /> *Headache<br /> *Euphoria<br /> *Cough<br /> <br /> ==Pharmacology==<br /> *Half-life: Highly variable (lipophilic, stored in adipose tissue)<br /> *Metabolism: Hepatic (CYP450); produces nephrotoxic metabolites (fluoride, oxalic acid)<br /> *Excretion: Renal (metabolites), pulmonary (unchanged drug)<br /> <br /> ==Mechanism of Action==<br /> *Fluorinated methyl ethyl ether; exact analgesic mechanism unclear<br /> *Acts as a CNS depressant providing analgesia at sub-anesthetic concentrations<br /> <br /> ==Comments==<br /> *Used widely in Australia, New Zealand, and parts of Europe for ED and prehospital analgesia<br /> *FDA-approved in the US in 2024 for short-term relief of moderate-to-severe acute pain in conscious adults<br /> *Self-administered via a handheld inhaler; onset within 6-10 breaths<br /> *Provides analgesia without loss of consciousness<br /> *Must not exceed dose limits due to nephrotoxicity risk<br /> *Previously withdrawn as a general anesthetic due to renal toxicity at high doses; low-dose analgesic use has a favorable safety profile<br /> <br /> ==Indications by Condition==<br /> ''The following table is automatically generated from disease/condition pages across WikEM.''<br /> {{#ask:[[Has DrugName::Methoxyflurane]]<br /> |?Has Indication=Indication<br /> |?Has Dose=Dose<br /> |?Has Context=Context<br /> |?Has Route=Route<br /> |?Has Population=Population<br /> |format=table<br /> |headers=plain<br /> |mainlabel=-<br /> |sort=Has Indication<br /> |limit=50<br /> }}<br /> <br /> ==See Also==<br /> *[[Acute pain management]]<br /> *[[Procedural sedation]]<br /> *[[Nitrous oxide]]<br /> <br /> ==References==<br /> &lt;references/&gt;<br /> <br /> [[Category:Pharmacology]]</div>

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