https://wikem.org/w/index.php?action=history&feed=atom&title=Mometasone_furoate%2FFormoterol_fumarate 2026-04-20T07:17:04Z Revision history for this page on the wiki MediaWiki 1.38.2 https://wikem.org/w/index.php?title=Mometasone_furoate/Formoterol_fumarate&diff=229529&oldid=prev 2019-09-22T23:40:18Z

<p><span dir="auto"><span class="autocomment">References</span></span></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 23:40, 22 September 2019</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l86">Line 86:</td> <td colspan="2" class="diff-lineno">Line 86:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;references/&gt;</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;references/&gt;</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Pharmacology]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Pharmacology]]</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Category:Pulmonology]]</ins></div></td></tr> </table>

ClaireLewis https://wikem.org/w/index.php?title=Mometasone_furoate/Formoterol_fumarate&diff=111818&oldid=prev 2016-11-24T01:12:34Z

<p>Creation of page</p> <p><b>New page</b></p><div>==Administration==<br /> *Type: [[Inhaled corticosteroid]]<br /> *Dosage Forms: 100 mcg/5 mg/spray, 200 mcg/5 mcg/spray MDI<br /> *Routes of Administration: Inhaled<br /> *Common Trade Names: Dulera<br /> <br /> ==Adult Dosing==<br /> *Prior medium dose inhaled steroid<br /> **2 puffs (100 mcg/5 mcg/spray) inhaled BID<br /> ***Max: 4 puffs/day<br /> ***Taper to lowest effective dose. Use shortest effective treatment duration.<br /> *Prior high dose inhaled steroid<br /> **2 puffs (200 mcg/5 mcg/spray) inhaled BID<br /> ***Max: 4 puffs/day<br /> ***Taper to lowest effective dose. Use shortest effective treatment duration.<br /> <br /> ==Pediatric Dosing==<br /> *12+ yo, prior medium dose inhaled steroid<br /> **2 puffs (100 mcg/5 mcg/spray) inhaled BID<br /> ***Max: 4 puffs/day<br /> ***Taper to lowest effective dose. Use shortest effective treatment duration.<br /> *12+ yo, prior high dose inhaled steroid<br /> **2 puffs (200 mcg/5 mcg/spray) inhaled BID<br /> ***Max: 4 puffs/day<br /> ***Taper to lowest effective dose. Use shortest effective treatment duration.<br /> <br /> ==Special Populations==<br /> *[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C; Possible risk of teratogenicity in animal data at 0.3-8x MRHD. Possible risk of delayed ossification at 80x MRHD.<br /> *[[Lactation risk categories|Lactation risk]]: L3; Safety unknown<br /> <br /> ===Renal Dosing===<br /> *Adult: Not defined<br /> *Pediatric: Not defined<br /> <br /> ===Hepatic Dosing===<br /> *Adult: Not defined. Caution in hepatic impairment.<br /> *Pediatric: Not defined. Caution in hepatic impairment<br /> <br /> ==Contraindications==<br /> *Allergy to class/drug<br /> *[[Asthma]], acute<br /> *Bronchospasm, acute<br /> <br /> ==Adverse Reactions==<br /> ===Serious===<br /> *Bronchospasm, paradoxical<br /> *[[Asthma]] exacerbation<br /> *Death, asthma-related<br /> *Hypersenstivity reaction<br /> *[[Anaphylaxis]]<br /> *Adrenal Suppression<br /> *Hypercorticism<br /> *Growth suppression in peds pts<br /> *[[Hypertension]]<br /> *[[Hypotension]]<br /> *[[Angina]]<br /> *[[Cardiac arrest]]<br /> *[[Arrhythmia]]<br /> *[[Hypokalemia]]<br /> *[[Hyperglycemia]]<br /> *[[Glaucoma]] in long-term use<br /> *Cataracts in long-term use<br /> <br /> ===Common===<br /> *Nasopharyngitis<br /> *[[Headache]]<br /> *[[Sinusitis]]<br /> *[[Candidiasis]], oral<br /> *[[Dysphonia]]<br /> <br /> ==Pharmacology==<br /> *Half-life: Mometasone: 5 hr. Formoterol: 10 hr.<br /> *Metabolism: Mometasone: Liver, CYP450: 3A4 substrate. Formoterol: Liver extensively, CYP450: 2A6, 2C9/19, 2D6 substrate.<br /> *Excretion: Mometasone: Feces 74%, Urine 8%. Formoterol: Urine 59-62% (10% unchanged), feces 32-34%.<br /> <br /> ==Mechanism of Action==<br /> *Mometasone: Exact mechanism of anti-inflammatory action unknown. Inhibits multiple inflammatory cytokines and produces multiple glucocorticoid and mineralcorticoid effects.<br /> *Formoterol: Selectively stimulates beta-2 adrenergic receptors, relaxing airway smooth muscle.<br /> <br /> ==Comments==<br /> Black Box Warning: Long acting beta-2 adrenergic agonists (LABA) increase risk of asthma-related death. LABA use may increase risk of asthma-related hospitalization in pediatric and adolescent patients. Do not use corticosteroid/LABA combo if asthma adequately controlled on low-or medium-dose inhaled corticosteroids.<br /> <br /> ==See Also==<br /> <br /> ==References==<br /> &lt;references/&gt;<br /> [[Category:Pharmacology]]</div>

Jonwarren