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Montelukast - Revision history
2026-04-18T17:14:04Z
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ClaireLewis: Created page with "==Administration== *Type: Leukotriene modifier *Dosage Forms: granules, chewable and conventional tablets *Routes of Administration: PO *Common Trade Names: Singulair ==Adult..."
2019-08-23T18:51:52Z
<p>Created page with "==Administration== *Type: Leukotriene modifier *Dosage Forms: granules, chewable and conventional tablets *Routes of Administration: PO *Common Trade Names: Singulair ==Adult..."</p>
<p><b>New page</b></p><div>==Administration==<br />
*Type: Leukotriene modifier<br />
*Dosage Forms: granules, chewable and conventional tablets<br />
*Routes of Administration: PO<br />
*Common Trade Names: Singulair<br />
<br />
==Adult Dosing==<br />
*Asthma (prophylaxis), allergic rhinitis: 10mg PO daily<br />
*Exercise-induced asthma: 10mg 2h prior to exercise max 10mg daily<br />
<br />
==Pediatric Dosing==<br />
*12-24mo: 4 mg (granules) PO daily<br />
*2-6y: 4 mg PO daily <br />
*6-15y: 5 mg PO daily <br />
*>15y: 10mg PO daily<br />
>15 years: 10 mg PO daily <br />
<br />
==Special Populations==<br />
===[[Drug pregnancy categories|Pregnancy Rating]]===<br />
*Category B<br />
<br />
===Lactation risk===<br />
*Low risk to infant<br />
<br />
===Renal Dosing===<br />
*Adult:<br />
*Pediatric:<br />
<br />
===Hepatic Dosing===<br />
*Adult:<br />
*Pediatric:<br />
<br />
==Contraindications==<br />
*Allergy to class/drug<br />
*Caution using chewable tablets in phenylketonuria (contain phenylalanine)<br />
<br />
==Adverse Reactions==<br />
===Serious===<br />
*Systemic eosinophilia with vasculitis consistent with Churg-Strauss syndrome<br />
*Neuropsychiatric events: aggressive behavior/agitation, anxiousness, hallucinations, suicidal ideation, somambulism<br />
<br />
===Common===<br />
*Headache, dizziness<br />
*Abdominal pain, dyspepsia, gastroenteritis<br />
*Elevated LFTs<br />
*Viral infection, laryngitis, pharyngitis, influenza, cough, otitis, nasal congestion, bronchitis, <br />
*Wheezing<br />
*Dental pain<br />
*Rash, urticaria<br />
<br />
<br />
==Pharmacology==<br />
*Half-life: 2.7-5.5h<br />
*Metabolism: Hepatic<br />
*Excretion: mostly in feces<br />
<br />
==Mechanism of Action==<br />
*Inhibits binding of leukotriene D4 to its receptor, thus interfering with inflammatory process involved with asthma symptoms<br />
<br />
==Comments==<br />
<br />
<br />
==See Also==<br />
*[[Asthma]]<br />
<br />
==References==<br />
Medscape<br />
<references/><br />
<br />
[[Category:Pharmacology]]</div>
ClaireLewis