Multisystem inflammatory syndrome in children - Revision history

Danbot: Add verified PubMed references (PMIDs 35314921, 33252101)

2026-03-22T10:49:13Z

Add verified PubMed references (PMIDs 35314921, 33252101)

← Older revision		Revision as of 10:49, 22 March 2026
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	==Background==		==Background==
	*In April 2020 during the [[SARS-CoV-2]] outbreak UK pediatricians alerted the National Health Service of a new systemic inflammatory condition similar to Kawasaki disease in children testing positive for the virus		*In April 2020 during the [[SARS-CoV-2]] outbreak UK pediatricians alerted the National Health Service of a new systemic inflammatory condition similar to Kawasaki disease in children testing positive for the virus<ref>Patel JM. Multisystem Inflammatory Syndrome in Children (MIS-C). Curr Allergy Asthma Rep. 2022 May;22(5):53-60. PMID 35314921</ref>
	*Cases were then reported worldwide with patients admitted to ICUs in the USA<sup>4,5,10</sup>, Canada<sup>10</sup>Italy<sup>11</sup>, and UK<sup>2,3</sup>		*Cases were then reported worldwide with patients admitted to ICUs in the USA<sup>4,5,10</sup>, Canada<sup>10</sup>Italy<sup>11</sup>, and UK<sup>2,3</sup>
	*Thought to be an immunologically mediated inflammatory syndrome associated with previous [[SARS-CoV-2]] infection<sup>1</sup>		*Thought to be an immunologically mediated inflammatory syndrome associated with previous [[SARS-CoV-2]] infection<sup>1</sup>
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	===Epidemiology===		===Epidemiology===
	*Occurs in 2/100,000 persons under 21<sup>4</sup>		*Occurs in 2/100,000 persons under 21<sup>4</sup>
	*In a systematic review published June 2020, 11/7780 (0.14%) COVID-19 positive children met the CDC’s criteria for MIS-C<sup>6</sup>		*In a systematic review published June 2020, 11/7780 (0.14%) COVID-19 positive children met the CDC’s criteria for MIS-C<sup>6</sup><ref>Panigrahy N, Policarpio J, Ramanathan R. Multisystem inflammatory syndrome in children and SARS-CoV-2: A scoping review. J Pediatr Rehabil Med. 2020;13(3):301-316. PMID 33252101</ref>

	==Clinical Features==		==Clinical Features==

Rossdonaldson1: /* References */

2024-02-07T18:33:34Z

References

← Older revision		Revision as of 18:33, 7 February 2024
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	<references/>		<references/>

	[[Category:~~COVID-19~~]]		[[Category:ID]]
	[[Category:Pediatrics]]		[[Category:Pediatrics]]
	# Capone CA et al. Characteristics, cardiac involvement, and outcomes of multisystem inflammatory disease of childhood (MIS-C) associated with SARS-CoV-2 infection. J Pediatr. 2020. (Epub ahead of print).		# Capone CA et al. Characteristics, cardiac involvement, and outcomes of multisystem inflammatory disease of childhood (MIS-C) associated with SARS-CoV-2 infection. J Pediatr. 2020. (Epub ahead of print).

ClaireLewis at 18:25, 25 October 2020

2020-10-25T18:25:27Z

← Older revision		Revision as of 18:25, 25 October 2020
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	*Thought to be an immunologically mediated inflammatory syndrome associated with previous [[SARS-CoV-2]] infection<sup>1</sup>		*Thought to be an immunologically mediated inflammatory syndrome associated with previous [[SARS-CoV-2]] infection<sup>1</sup>
	**Cases occur 3-5.5 weeks after patients tested positive for [[SARS-CoV-2]]		**Cases occur 3-5.5 weeks after patients tested positive for [[SARS-CoV-2]]
	*While Kawasaki disease has a predilection for children of Asian descent, MIS-C seems to affect African American children more often<sup>9</sup>		*While [[Kawasaki]] disease has a predilection for children of Asian descent, MIS-C seems to affect African American children more often<sup>9</sup>
	**Compared to Kawasaki patients are generally older (median age 8.6 vs 2.5)<sup>1</sup> and had a predominance of GI symptoms		**Compared to Kawasaki patients are generally older (median age 8.6 vs 2.5)<sup>1</sup> and had a predominance of GI symptoms
	*Patients with MIS-C are significantly more likely to present with dyspnea, vomiting, diarrhea, lymphopenia, and elevated LDH and and D-dimer compared to patients with [[COVID-19]] without MIS-C <sup>6</sup>		*Patients with MIS-C are significantly more likely to present with [[dyspnea]], [[vomiting]], [[diarrhea]], lymphopenia, and elevated LDH and and D-dimer compared to patients with [[COVID-19]] without MIS-C <sup>6</sup>

	===Epidemiology===		===Epidemiology===
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	*[[Rash]]		*[[Rash]]
	*[[Sore throat]]		*[[Sore throat]]
	*[[Cardiac dysfunction]]		*Cardiac dysfunction
	*[[Shock]]		*[[Shock]]
	*[[Acute kidney injury]]		*[[Acute kidney injury]]
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	*Imaging		*Imaging
	**Chest X-ray/CT		**[[Chest X-ray]]/CT
	***May show bilateral patchy infiltrates or ground glass opacities		***May show bilateral patchy infiltrates or ground glass opacities
	**Echocardiogram to evaluate for LV dysfunction, coronary aneurysm/dilation		**[[echocardiography\|Echocardiogram]] to evaluate for LV dysfunction, coronary aneurysm/dilation

	===Case Definition===		===Case Definition===
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	==Management==		==Management==
	*ASA		*[[ASA]]
	*IVIG		*[[IVIG]]
	*Corticosteroids (shock or risk of coronary ~~anueryms~~)<sup>1</sup>		*[[Corticosteroids]] (shock or risk of coronary aneurysm)<sup>1</sup>
	*Antibiotics for sepsis or pneumonia		*[[Antibiotics]] for sepsis or pneumonia
	*Mechanical ventilation		*[[Mechanical ventilation]]
	*Vasopressors		*[[Vasopressors]]
	*Biologics (unresponsive to IVIG and steroids)<sup>1</sup>		*Biologics (unresponsive to IVIG and steroids)<sup>1</sup>
	*ECMO		*[[ECMO]]

	===Complications===		===Complications===
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	[[Category:COVID-19]]		[[Category:COVID-19]]
			[[Category:Pediatrics]]
	# Capone CA et al. Characteristics, cardiac involvement, and outcomes of multisystem inflammatory disease of childhood (MIS-C) associated with SARS-CoV-2 infection. J Pediatr. 2020. (Epub ahead of print).		# Capone CA et al. Characteristics, cardiac involvement, and outcomes of multisystem inflammatory disease of childhood (MIS-C) associated with SARS-CoV-2 infection. J Pediatr. 2020. (Epub ahead of print).
	# Chiotos K et al. Multisystem Inflammatory Syndrome in Children During the Coronavirus 2019 Pandemic: A Case Series. J Pediatric Infect Dis Soc. 2020;9(3):393-398.		# Chiotos K et al. Multisystem Inflammatory Syndrome in Children During the Coronavirus 2019 Pandemic: A Case Series. J Pediatric Infect Dis Soc. 2020;9(3):393-398.

Fredvarone: /* Evaluation */

2020-08-07T22:17:31Z

Evaluation

← Older revision		Revision as of 22:17, 7 August 2020
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	**Chest X-ray/CT		**Chest X-ray/CT
	***May show bilateral patchy infiltrates or ground glass opacities		***May show bilateral patchy infiltrates or ground glass opacities
			**Echocardiogram to evaluate for LV dysfunction, coronary aneurysm/dilation

	===Case Definition===		===Case Definition===

Fredvarone: /* Complications */

2020-08-04T15:28:42Z

Complications

← Older revision		Revision as of 15:28, 4 August 2020
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	===Complications===		===Complications===
	*Coronary artery aneurysm (15-23%)<sup>1,3</sup>
	*Coronary artery dilation (9%)<sup>1</sup>
	*Acute kidney injury (10%)<sup>4</sup>
	*Mechanical ventilation (10-46%)<sup>1,3,4,5</sup>
	*Vasopressor need (62%-83%)<sup>1,3,4</sup>


			{\| {{table}}
			\| align="center" style="background:#f0f0f0;"\|''''''
			\| align="center" style="background:#f0f0f0;"\|'''Study'''
			\| align="center" style="background:#f0f0f0;"\|'''Capone et al.<sup>1</sup>'''
			\| align="center" style="background:#f0f0f0;"\|'''Davies et al.<sup>3</sup>'''
			\| align="center" style="background:#f0f0f0;"\|'''Dufort et al.<sup>4</sup>'''
			\| align="center" style="background:#f0f0f0;"\|'''Fields et al.<sup>5</sup>'''
			\| align="center" style="background:#f0f0f0;"\|'''Lee et al.<sup>7</sup>'''
			\| align="center" style="background:#f0f0f0;"\|'''Shekerdemian et al.<sup>10</sup>'''
			\|-
			\| Complication (%)\|\|ICU admission\|\|79\|\|100%<sup>i</sup>\|\|80\|\|80\|\|61\|\|100%<sup>i</sup>
			\|-
			\| \|\|Invasive mechanical ventilation\|\|18\|\|46\|\|10\|\|20\|\|0\|\|38
			\|-
			\| \|\|Vasopressor support\|\|76\|\|83\|\|62\|\|48\|\|25\|\|25
			\|-
			\| \|\|Coronary artery abnormalities\|\|24\|\|36\|\|9\|\|8\|\|21\|\|N/A
			\|-
			\| \|\|LV dysfunction\|\|19\|\|N/A\|\|52\|\|38\|\|39\|\|N/A
			\|-
			\| \|\|Acute kidney injury \|\|70\|\|N/A\|\|10\|\|5\|\|21\|\|N/A
			\|-
			\| \|\|RRT\|\|N/A\|\|1\|\|N/A\|\|N/A\|\|N/A\|\|0
			\|-
			\| \|\|ECMO\|\|N/A\|\|4\|\|4\|\|4\|\|0\|\|2
			\|-
			\| \|\|Death\|\|0\|\|3\|\|2\|\|2\|\|0\|\|4
			\|}

			<sup>i</sup>Study contained only patients admitted to pediatric ICUs.

	==Disposition==		==Disposition==

Fredvarone at 15:20, 4 August 2020

2020-08-04T15:20:22Z

Show changes

Rossdonaldson1: /* References */

2020-05-18T16:49:47Z

References

← Older revision		Revision as of 16:49, 18 May 2020
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	==References==		==References==
	<references/>		<references/>

			[[Category:COVID-19]]

Rossdonaldson1: Rossdonaldson1 moved page Pediatric multi-system inflammatory syndrome to Multisystem inflammatory syndrome in children

2020-05-18T16:42:34Z

Rossdonaldson1 moved page Pediatric multi-system inflammatory syndrome to Multisystem inflammatory syndrome in children

← Older revision	Revision as of 16:42, 18 May 2020
(No difference)

Rossdonaldson1: /* External Links */

2020-05-18T16:34:12Z

External Links

← Older revision		Revision as of 16:34, 18 May 2020
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	==External Links==		==External Links==
	*[https://~~secureweb.cisco~~.com/1sVjHLj_qQIGIzsDPe3A65XwAJfefiqVTF5wRLd7qvpQBSyNqf24TEAo8mt-909wYob1eSeWFbcHX50FJYCQ8nZTNQO10r2SkLENZ1HQWHdJk9R55a3288xHeDM9hm5W5dycjyByu84lOV_CMfAQd1Dru8Eim4f9ztUbwBp9refyfB_zTWqMnLDrgWuQa1GNdZDHOtvEKOFPiIjLdDH9tI_Uuu71qnIDJlcBdn4vfGA6RHIzBoeU2PHks1ZQFKgAhEi0EiDo3kXZZbKp5i2fazg/~~https%3A%2F%2Ftotalwebcasting.com%2Fview%2F%3Ffunc%3DVOFF%26id%3Dnysdoh%26date%3D2020~~-05-14~~%26seq%3D1~~ NY Webinar]		*[https://totalwebcasting.com/view/?func=VOFF&id=nysdoh&date=2020-05-14&seq=1 NY Webinar]

	==References==		==References==
	<references/>		<references/>

Rossdonaldson1: /* External Links */

2020-05-18T16:33:35Z

External Links

← Older revision		Revision as of 16:33, 18 May 2020
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	==External Links==		==External Links==
	*https://secureweb.cisco.com/1sVjHLj_qQIGIzsDPe3A65XwAJfefiqVTF5wRLd7qvpQBSyNqf24TEAo8mt-909wYob1eSeWFbcHX50FJYCQ8nZTNQO10r2SkLENZ1HQWHdJk9R55a3288xHeDM9hm5W5dycjyByu84lOV_CMfAQd1Dru8Eim4f9ztUbwBp9refyfB_zTWqMnLDrgWuQa1GNdZDHOtvEKOFPiIjLdDH9tI_Uuu71qnIDJlcBdn4vfGA6RHIzBoeU2PHks1ZQFKgAhEi0EiDo3kXZZbKp5i2fazg/https%3A%2F%2Ftotalwebcasting.com%2Fview%2F%3Ffunc%3DVOFF%26id%3Dnysdoh%26date%3D2020-05-14%26seq%3D1		*[https://secureweb.cisco.com/1sVjHLj_qQIGIzsDPe3A65XwAJfefiqVTF5wRLd7qvpQBSyNqf24TEAo8mt-909wYob1eSeWFbcHX50FJYCQ8nZTNQO10r2SkLENZ1HQWHdJk9R55a3288xHeDM9hm5W5dycjyByu84lOV_CMfAQd1Dru8Eim4f9ztUbwBp9refyfB_zTWqMnLDrgWuQa1GNdZDHOtvEKOFPiIjLdDH9tI_Uuu71qnIDJlcBdn4vfGA6RHIzBoeU2PHks1ZQFKgAhEi0EiDo3kXZZbKp5i2fazg/https%3A%2F%2Ftotalwebcasting.com%2Fview%2F%3Ffunc%3DVOFF%26id%3Dnysdoh%26date%3D2020-05-14%26seq%3D1 NY Webinar]

	==References==		==References==
	<references/>		<references/>