Jonrako: /* Mechanism of Action */

2022-01-17T05:26:28Z

Mechanism of Action

← Older revision		Revision as of 05:26, 17 January 2022
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	==Mechanism of Action==		==Mechanism of Action==
	* ~~Opioid~~ competitive receptor antagonist		* Potent nonselective opioid competitive receptor antagonist
			*Reduces the rewarding effects of alcohol consumption by inhibiting the activity of endogenous opioids in the mesolimbic system. <ref>Anderson, E., Chamberlin, M., Zuluaga, M., Ullal, M., & Hawk, K. (2021). Annals of emergency medicine. Annals of Emergency Medicine, 78(6), 752–758. </ref>

	==Comments==		==Comments==

ClaireLewis: Created page with "==Administration== Type: Opioid antagonist Dosage Forms: Routes of Administration: PO, IM Common Trade Names: ReVia, Vivitrol, Depade ==Adult Dosing== *Opioid dependence..."

2019-09-01T23:11:18Z

Created page with "==Administration== *Type: Opioid antagonist *Dosage Forms: *Routes of Administration: PO, IM *Common Trade Names: ReVia, Vivitrol, Depade ==Adult Dosing== *Opioid dependence..."

New page

==Administration==
*Type: Opioid antagonist
*Dosage Forms:
*Routes of Administration: PO, IM
*Common Trade Names: ReVia, Vivitrol, Depade

==Adult Dosing==
*Opioid dependence (prevention of relapse after opioid-free x 7-10d), ETOH dependence: 25-50mg PO daily OR 380mg IM q4w

==Pediatric Dosing==
''Safety/efficacy not established''

==Special Populations==
===[[Drug pregnancy categories|Pregnancy Rating]]===
*Category C

===Lactation risk===
*Minimally excreted in breastmilk

===Renal Dosing===
*Use caution

===Hepatic Dosing===
*Use caution

==Contraindications==
*Allergy to class/drug
*Patients who are on opioid analgesics/partial agonists, are opioid-dependant, or in acute opioid withdrawal

==Adverse Reactions==
===Serious===
*Depression, suicide, and suicidality
*Vulnerability to opioid overdose: Patients should be alerted that they may be more sensitive to opioids, even at lower doses, after discontinuance of naltrexone
*Hepatotoxicity
*Severe injection-site reactions (e.g. necrosis, cellulitis, hematoma)

===Common===
*Injection site reaction
*Nausea/vomiting, diarrhea, decreased appetite, dry mouth
*LFT abnormalities,
*Elevated CPK
*Headache, dizziness, anxiety, insomnia, somnolence
*URI, pharyngitis
*Arthralgia, muscle cramps, back pain
*Rash

==Pharmacology==
*Half-life: PO- 4-13h;IM- 5-10 days
*Metabolism: Hepatic
*Excretion: Urinary

==Mechanism of Action==
* Opioid competitive receptor antagonist

==Comments==

==See Also==
*[[Opioids]]

==References==
<references/>

[[Category:Pharmacology]]

Naltrexone - Revision history

Jonrako: /* Mechanism of Action */

ClaireLewis: Created page with "==Administration== *Type: Opioid antagonist *Dosage Forms: *Routes of Administration: PO, IM *Common Trade Names: ReVia, Vivitrol, Depade ==Adult Dosing== *Opioid dependence..."

ClaireLewis: Created page with "==Administration== Type: Opioid antagonist Dosage Forms: Routes of Administration: PO, IM Common Trade Names: ReVia, Vivitrol, Depade ==Adult Dosing== *Opioid dependence..."